Interleukin-24 is a novel diagnostic biomarker for the severity of acute kidney injury
There is a clinical need for sensitive acute kidney injury (AKI) biomarkers that enable early therapeutic interventions and prediction of disease prognosis. In this study, we monitored interleukin (IL)-24 expressed in kidneys with severe AKI that progresses to atrophic kidney in a mouse model of isc...
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| Veröffentlicht in: | Medical molecular morphology 2020-06, Vol.53 (2), p.115-123 |
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| creator | Tabata, Tomotake Sugiyama, Noriyuki Otsuki, Yoshinori Kondo, Yoichi |
| description | There is a clinical need for sensitive acute kidney injury (AKI) biomarkers that enable early therapeutic interventions and prediction of disease prognosis. In this study, we monitored interleukin (IL)-24 expressed in kidneys with severe AKI that progresses to atrophic kidney in a mouse model of ischemia–reperfusion injury (IRI). Therefore, we evaluated IL-24 as a potential biomarker not only for early diagnosis of AKI, but also for predicting progression to chronic kidney disease (CKD). Serum IL-24 was detected earlier than the elevation of serum creatinine levels and urinary IL-24 was detected as early as neutrophil gelatinase associated lipocalin (NGAL) in severe AKI (60 min of IRI). In addition, serum and urine IL-24 levels tended to increase in relation to ischemia duration. In such kidneys, vascular smooth muscle cells expressed IL-24 in response to the injury in the renal tubular epithelial cell and its target was the renal tubular epithelial cell itself. IL-24 may play a pivotal role in the communication between tubular epithelial cells and vascular smooth muscle cells and, in conclusion, IL-24 can be used as a sensitive biomarker for AKI. |
| doi_str_mv | 10.1007/s00795-019-00239-0 |
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In this study, we monitored interleukin (IL)-24 expressed in kidneys with severe AKI that progresses to atrophic kidney in a mouse model of ischemia–reperfusion injury (IRI). Therefore, we evaluated IL-24 as a potential biomarker not only for early diagnosis of AKI, but also for predicting progression to chronic kidney disease (CKD). Serum IL-24 was detected earlier than the elevation of serum creatinine levels and urinary IL-24 was detected as early as neutrophil gelatinase associated lipocalin (NGAL) in severe AKI (60 min of IRI). In addition, serum and urine IL-24 levels tended to increase in relation to ischemia duration. In such kidneys, vascular smooth muscle cells expressed IL-24 in response to the injury in the renal tubular epithelial cell and its target was the renal tubular epithelial cell itself. IL-24 may play a pivotal role in the communication between tubular epithelial cells and vascular smooth muscle cells and, in conclusion, IL-24 can be used as a sensitive biomarker for AKI.</description><identifier>ISSN: 1860-1480</identifier><identifier>EISSN: 1860-1499</identifier><identifier>DOI: 10.1007/s00795-019-00239-0</identifier><identifier>PMID: 31802235</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Acute Kidney Injury - blood ; Acute Kidney Injury - diagnosis ; Acute Kidney Injury - pathology ; Acute Kidney Injury - urine ; Anatomy ; Animals ; Atrophy - blood ; Atrophy - diagnosis ; Atrophy - pathology ; Atrophy - urine ; Biomarkers ; Biomarkers - blood ; Biomarkers - metabolism ; Biomarkers - urine ; Cell Communication ; Cell interactions ; Cells, Cultured ; Creatinine ; Cytokines ; Cytokines - blood ; Cytokines - metabolism ; Cytokines - urine ; Disease Models, Animal ; Disease Progression ; Epithelial cells ; Epithelial Cells - pathology ; Gelatinase ; Humans ; Interleukin 24 ; Ischemia ; Kidney diseases ; Kidney Tubules - blood supply ; Kidney Tubules - cytology ; Kidney Tubules - pathology ; Kidneys ; Lipocalin ; Lipocalin-2 - blood ; Male ; Medical diagnosis ; Medicine ; Medicine & Public Health ; Mice ; Molecular Medicine ; Muscle, Smooth, Vascular - cytology ; Muscle, Smooth, Vascular - pathology ; Myocytes, Smooth Muscle - pathology ; Original Paper ; Pathology ; Primary Cell Culture ; Prognosis ; Reperfusion ; Reperfusion Injury - blood ; Reperfusion Injury - diagnosis ; Reperfusion Injury - pathology ; Reperfusion Injury - urine ; Severity of Illness Index ; Smooth muscle ; Therapeutic applications</subject><ispartof>Medical molecular morphology, 2020-06, Vol.53 (2), p.115-123</ispartof><rights>The Japanese Society for Clinical Molecular Morphology 2019</rights><rights>The Japanese Society for Clinical Molecular Morphology 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-8690502a2c7b21a5d43d146074be51703948d2522b683713a69967e30a89adfe3</citedby><cites>FETCH-LOGICAL-c483t-8690502a2c7b21a5d43d146074be51703948d2522b683713a69967e30a89adfe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00795-019-00239-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00795-019-00239-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31802235$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tabata, Tomotake</creatorcontrib><creatorcontrib>Sugiyama, Noriyuki</creatorcontrib><creatorcontrib>Otsuki, Yoshinori</creatorcontrib><creatorcontrib>Kondo, Yoichi</creatorcontrib><title>Interleukin-24 is a novel diagnostic biomarker for the severity of acute kidney injury</title><title>Medical molecular morphology</title><addtitle>Med Mol Morphol</addtitle><addtitle>Med Mol Morphol</addtitle><description>There is a clinical need for sensitive acute kidney injury (AKI) biomarkers that enable early therapeutic interventions and prediction of disease prognosis. In this study, we monitored interleukin (IL)-24 expressed in kidneys with severe AKI that progresses to atrophic kidney in a mouse model of ischemia–reperfusion injury (IRI). Therefore, we evaluated IL-24 as a potential biomarker not only for early diagnosis of AKI, but also for predicting progression to chronic kidney disease (CKD). Serum IL-24 was detected earlier than the elevation of serum creatinine levels and urinary IL-24 was detected as early as neutrophil gelatinase associated lipocalin (NGAL) in severe AKI (60 min of IRI). In addition, serum and urine IL-24 levels tended to increase in relation to ischemia duration. In such kidneys, vascular smooth muscle cells expressed IL-24 in response to the injury in the renal tubular epithelial cell and its target was the renal tubular epithelial cell itself. IL-24 may play a pivotal role in the communication between tubular epithelial cells and vascular smooth muscle cells and, in conclusion, IL-24 can be used as a sensitive biomarker for AKI.</description><subject>Acute Kidney Injury - blood</subject><subject>Acute Kidney Injury - diagnosis</subject><subject>Acute Kidney Injury - pathology</subject><subject>Acute Kidney Injury - urine</subject><subject>Anatomy</subject><subject>Animals</subject><subject>Atrophy - blood</subject><subject>Atrophy - diagnosis</subject><subject>Atrophy - pathology</subject><subject>Atrophy - urine</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - metabolism</subject><subject>Biomarkers - urine</subject><subject>Cell Communication</subject><subject>Cell interactions</subject><subject>Cells, Cultured</subject><subject>Creatinine</subject><subject>Cytokines</subject><subject>Cytokines - blood</subject><subject>Cytokines - metabolism</subject><subject>Cytokines - urine</subject><subject>Disease Models, Animal</subject><subject>Disease Progression</subject><subject>Epithelial cells</subject><subject>Epithelial Cells - pathology</subject><subject>Gelatinase</subject><subject>Humans</subject><subject>Interleukin 24</subject><subject>Ischemia</subject><subject>Kidney diseases</subject><subject>Kidney Tubules - blood supply</subject><subject>Kidney Tubules - cytology</subject><subject>Kidney Tubules - pathology</subject><subject>Kidneys</subject><subject>Lipocalin</subject><subject>Lipocalin-2 - blood</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mice</subject><subject>Molecular Medicine</subject><subject>Muscle, Smooth, Vascular - cytology</subject><subject>Muscle, Smooth, Vascular - pathology</subject><subject>Myocytes, Smooth Muscle - pathology</subject><subject>Original Paper</subject><subject>Pathology</subject><subject>Primary Cell Culture</subject><subject>Prognosis</subject><subject>Reperfusion</subject><subject>Reperfusion Injury - blood</subject><subject>Reperfusion Injury - diagnosis</subject><subject>Reperfusion Injury - pathology</subject><subject>Reperfusion Injury - urine</subject><subject>Severity of Illness Index</subject><subject>Smooth muscle</subject><subject>Therapeutic applications</subject><issn>1860-1480</issn><issn>1860-1499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtr3TAQRkVpyfsPdFEE2WTjdvSypGUISRsIdNNkK2R7nOpeXymR7MD991Vz84AuuhkJ5swnzSHkM4OvDEB_K7VY1QCzDQAXtX4gB8y00DBp7ce3u4F9cljKCkDolqs9si-YAc6FOiB313HGPOGyDrHhkoZCPY3pCSc6BH8fU5lDT7uQNj6vMdMxZTr_RlrwCXOYtzSN1PfLjHQdhohbGuJqydtj8mn0U8GTl_OI3F5d_rr40dz8_H59cX7T9NKIuTGtBQXc8153nHk1SDEw2YKWHSqmQVhpBq4471ojNBO-tbbVKMAb64cRxRE52-U-5PS4YJndJpQep8lHTEtxXHDOpBCgKnr6D7pKS471d45LaJnSWplK8R3V51RKxtE95FB33zoG7q91t7PuqnX3bN1BHfryEr10GxzeRl41V0DsgFJb8R7z-9v_if0DBWCKug</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Tabata, Tomotake</creator><creator>Sugiyama, Noriyuki</creator><creator>Otsuki, Yoshinori</creator><creator>Kondo, Yoichi</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20200601</creationdate><title>Interleukin-24 is a novel diagnostic biomarker for the severity of acute kidney injury</title><author>Tabata, Tomotake ; Sugiyama, Noriyuki ; Otsuki, Yoshinori ; Kondo, Yoichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-8690502a2c7b21a5d43d146074be51703948d2522b683713a69967e30a89adfe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acute Kidney Injury - blood</topic><topic>Acute Kidney Injury - diagnosis</topic><topic>Acute Kidney Injury - pathology</topic><topic>Acute Kidney Injury - urine</topic><topic>Anatomy</topic><topic>Animals</topic><topic>Atrophy - blood</topic><topic>Atrophy - diagnosis</topic><topic>Atrophy - pathology</topic><topic>Atrophy - urine</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Biomarkers - metabolism</topic><topic>Biomarkers - urine</topic><topic>Cell Communication</topic><topic>Cell interactions</topic><topic>Cells, Cultured</topic><topic>Creatinine</topic><topic>Cytokines</topic><topic>Cytokines - blood</topic><topic>Cytokines - metabolism</topic><topic>Cytokines - urine</topic><topic>Disease Models, Animal</topic><topic>Disease Progression</topic><topic>Epithelial cells</topic><topic>Epithelial Cells - pathology</topic><topic>Gelatinase</topic><topic>Humans</topic><topic>Interleukin 24</topic><topic>Ischemia</topic><topic>Kidney diseases</topic><topic>Kidney Tubules - blood supply</topic><topic>Kidney Tubules - cytology</topic><topic>Kidney Tubules - pathology</topic><topic>Kidneys</topic><topic>Lipocalin</topic><topic>Lipocalin-2 - blood</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mice</topic><topic>Molecular Medicine</topic><topic>Muscle, Smooth, Vascular - cytology</topic><topic>Muscle, Smooth, Vascular - pathology</topic><topic>Myocytes, Smooth Muscle - pathology</topic><topic>Original Paper</topic><topic>Pathology</topic><topic>Primary Cell Culture</topic><topic>Prognosis</topic><topic>Reperfusion</topic><topic>Reperfusion Injury - blood</topic><topic>Reperfusion Injury - diagnosis</topic><topic>Reperfusion Injury - pathology</topic><topic>Reperfusion Injury - urine</topic><topic>Severity of Illness Index</topic><topic>Smooth muscle</topic><topic>Therapeutic applications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tabata, Tomotake</creatorcontrib><creatorcontrib>Sugiyama, Noriyuki</creatorcontrib><creatorcontrib>Otsuki, Yoshinori</creatorcontrib><creatorcontrib>Kondo, Yoichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Medical molecular morphology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tabata, Tomotake</au><au>Sugiyama, Noriyuki</au><au>Otsuki, Yoshinori</au><au>Kondo, Yoichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-24 is a novel diagnostic biomarker for the severity of acute kidney injury</atitle><jtitle>Medical molecular morphology</jtitle><stitle>Med Mol Morphol</stitle><addtitle>Med Mol Morphol</addtitle><date>2020-06-01</date><risdate>2020</risdate><volume>53</volume><issue>2</issue><spage>115</spage><epage>123</epage><pages>115-123</pages><issn>1860-1480</issn><eissn>1860-1499</eissn><abstract>There is a clinical need for sensitive acute kidney injury (AKI) biomarkers that enable early therapeutic interventions and prediction of disease prognosis. In this study, we monitored interleukin (IL)-24 expressed in kidneys with severe AKI that progresses to atrophic kidney in a mouse model of ischemia–reperfusion injury (IRI). Therefore, we evaluated IL-24 as a potential biomarker not only for early diagnosis of AKI, but also for predicting progression to chronic kidney disease (CKD). Serum IL-24 was detected earlier than the elevation of serum creatinine levels and urinary IL-24 was detected as early as neutrophil gelatinase associated lipocalin (NGAL) in severe AKI (60 min of IRI). In addition, serum and urine IL-24 levels tended to increase in relation to ischemia duration. In such kidneys, vascular smooth muscle cells expressed IL-24 in response to the injury in the renal tubular epithelial cell and its target was the renal tubular epithelial cell itself. IL-24 may play a pivotal role in the communication between tubular epithelial cells and vascular smooth muscle cells and, in conclusion, IL-24 can be used as a sensitive biomarker for AKI.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>31802235</pmid><doi>10.1007/s00795-019-00239-0</doi><tpages>9</tpages></addata></record> |
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| ispartof | Medical molecular morphology, 2020-06, Vol.53 (2), p.115-123 |
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| subjects | Acute Kidney Injury - blood Acute Kidney Injury - diagnosis Acute Kidney Injury - pathology Acute Kidney Injury - urine Anatomy Animals Atrophy - blood Atrophy - diagnosis Atrophy - pathology Atrophy - urine Biomarkers Biomarkers - blood Biomarkers - metabolism Biomarkers - urine Cell Communication Cell interactions Cells, Cultured Creatinine Cytokines Cytokines - blood Cytokines - metabolism Cytokines - urine Disease Models, Animal Disease Progression Epithelial cells Epithelial Cells - pathology Gelatinase Humans Interleukin 24 Ischemia Kidney diseases Kidney Tubules - blood supply Kidney Tubules - cytology Kidney Tubules - pathology Kidneys Lipocalin Lipocalin-2 - blood Male Medical diagnosis Medicine Medicine & Public Health Mice Molecular Medicine Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - pathology Myocytes, Smooth Muscle - pathology Original Paper Pathology Primary Cell Culture Prognosis Reperfusion Reperfusion Injury - blood Reperfusion Injury - diagnosis Reperfusion Injury - pathology Reperfusion Injury - urine Severity of Illness Index Smooth muscle Therapeutic applications |
| title | Interleukin-24 is a novel diagnostic biomarker for the severity of acute kidney injury |
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