RNA Splicing by the Spliceosome

The spliceosome removes introns from messenger RNA precursors (pre-mRNA). Decades of biochemistry and genetics combined with recent structural studies of the spliceosome have produced a detailed view of the mechanism of splicing. In this review, we aim to make this mechanism understandable and provi...

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Veröffentlicht in:	Annual review of biochemistry 2020-06, Vol.89 (1), p.359-388
Hauptverfasser:	Wilkinson, Max E, Charenton, Clément, Nagai, Kiyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine cryo-electron microscopy cryo-EM crystallography Genetics helicases Introns Metal ions mRNA pre-mRNA splicing Ribonucleoproteins Ribonucleoproteins (small nuclear) RNA catalysis snRNA spliceosome Splicing Unwinding
Online-Zugang:	Volltext
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