Deep sea minerals ameliorate diabetic‐induced inflammation via inhibition of TNFα signaling pathways

It has been well‐documented that the consumption of deep sea water (DSW) has beneficial effects on myocardial hypertrophy and cardiac apoptosis induced by hypercholesterolemia. However, the molecular mechanisms for the anti‐inflammatory effects of DSW on diabetic cardiomyopathy are still largely unc...

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Veröffentlicht in:	Environmental toxicology 2020-04, Vol.35 (4), p.468-477
Hauptverfasser:	Lu, Chieh‐Hsiang, Ou, Hsiu‐Chung, Day, Cecilia‐Hsuan, Chen, Hsiu‐I, Pai, Pei‐Ying, Lee, Cheng‐Yu, Chen, Ray‐Jade, Chang, Ruey‐Lin, PadmaViswanadha, Vijaya, Hsieh, Dennis Jine‐Yuan, Huang, Chih‐Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - therapeutic use Apoptosis Cardiomyopathy Cardiovascular diseases Chemical compounds Deep sea Deep sea environments Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - immunology Diabetic Cardiomyopathies - immunology Diabetic Cardiomyopathies - prevention & control Dosage Downstream effects Equivalence Heart Hypercholesterolemia Hypertrophy Immunofluorescence Inflammation Kinases Levels Magnesium Male Minerals Minerals - administration & dosage Minerals - therapeutic use Molecular modelling Myocardium - immunology Myocytes, Cardiac - drug effects Myocytes, Cardiac - immunology Myocytes, Cardiac - pathology Nitric oxide Nitric-oxide synthase Pharmacology Phosphorylation Prostaglandin endoperoxide synthase Proteins Rats Rats, Sprague-Dawley Seawater Seawater - chemistry Signal Transduction Signaling Streptozocin Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α
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