Insights in tuberculosis immunology: Role of NKT and T regulatory cells
Tuberculosis (TB) control is challenging due to poor drug compliance and emerging resistance. The need of the hour is to determine the prediction of disease cure and relapse. Patients' immune response is crucial to the disease outcome. This study was designed to study the immune profile of TB p...
Gespeichert in:
| Veröffentlicht in: | International journal of mycobacteriology 2019-10, Vol.8 (4), p.333-340 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 340 |
|---|---|
| container_issue | 4 |
| container_start_page | 333 |
| container_title | International journal of mycobacteriology |
| container_volume | 8 |
| creator | Pandey, Pooja Bhatnagar, Anuj Kumar Mohan, Anant Sachdeva, Kuldeep Singh Vajpayee, Madhu Das, Bimal Kumar Samantaray, Jyotish Chandra Guleria, Randeep Singh, Urvashi Balbir |
| description | Tuberculosis (TB) control is challenging due to poor drug compliance and emerging resistance. The need of the hour is to determine the prediction of disease cure and relapse. Patients' immune response is crucial to the disease outcome. This study was designed to study the immune profile of TB patients during treatment and cure.
The cross-sectional study included newly diagnosed pulmonary TB patients and healthy controls. Levels of serum cytokines/chemokines (Th1/Th2/Th17) were measured by BD cytometric bead array. The cell surface markers assessed in the study were CD3, CD4, CD8, CD16, CD56, and BD human regulatory T cell cocktail (CD4/CD25/CD127).
Data analysis observed statistically significant differences in CD3dim/CD56 + natural killer T (NKT) among TB patients with significantly low levels in healthy controls and after treatment completion (P < 0.0001). The analysis also revealed a high percentage of CD3dim/CD56 + NKT in fast responders. The percentage of T regulatory was found to be high in patients when compared with healthy controls; the values were statistically significant (0.0002). Interleukin-6 was significantly associated with the disease (P < 0.0485).
A comprehensive understanding of role of CD3dim/CD56+ NKT in antimycobacterial immunity may enable new possibilities for NK cell-based prophylactic and/or therapeutic strategies against TB. |
| doi_str_mv | 10.4103/ijmy.ijmy_141_19 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2320875012</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A745099168</galeid><sourcerecordid>A745099168</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-a79754a6335ad9377e021d8b215d9524daecb274cca618ea5b9359413514e06a3</originalsourceid><addsrcrecordid>eNptkUtLxDAURoMoKurelQTc6GLGPCdTdyI-BkVBR3AX0vS2RtpGkxacf2_qqDhgAnlxvnCTg9A-JWNBCT9xr81iPAyaCqpptoa2GaNsJKV4Xv9dc7qF9mJ8JakpldHJdBNtcaoyLgnbRlezNrrqpYvYtbjrcwi2r310ad80fetrXy1O8YOvAfsS393MsWkLPMcBqr42nQ8LbKGu4y7aKE0dYe973kFPlxfz8-vR7f3V7PzsdmSFYN3IqExJYSacS1NkXCkgjBbTnFFZZJKJwoDNmRLWmgmdgpF5qjMTlEsqgEwM30FHy3vfgn_vIXa6cXGowLTg-6gZZ2SqJKEsoYdLtDI1aNeWvgvGDrg-U0KSbPiMRI3_oVIvoHHWt1C6dL4SOF4JJKaDj64yfYx69viwypIla4OPMUCp34JrTEjKiB4k6i9_fySmyMH3A_u8geI38KOMfwIAFpbA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2320875012</pqid></control><display><type>article</type><title>Insights in tuberculosis immunology: Role of NKT and T regulatory cells</title><source>MEDLINE</source><source>Medknow Open Access Medical Journals</source><source>DOAJ Directory of Open Access Journals</source><creator>Pandey, Pooja ; Bhatnagar, Anuj Kumar ; Mohan, Anant ; Sachdeva, Kuldeep Singh ; Vajpayee, Madhu ; Das, Bimal Kumar ; Samantaray, Jyotish Chandra ; Guleria, Randeep ; Singh, Urvashi Balbir</creator><creatorcontrib>Pandey, Pooja ; Bhatnagar, Anuj Kumar ; Mohan, Anant ; Sachdeva, Kuldeep Singh ; Vajpayee, Madhu ; Das, Bimal Kumar ; Samantaray, Jyotish Chandra ; Guleria, Randeep ; Singh, Urvashi Balbir</creatorcontrib><description>Tuberculosis (TB) control is challenging due to poor drug compliance and emerging resistance. The need of the hour is to determine the prediction of disease cure and relapse. Patients' immune response is crucial to the disease outcome. This study was designed to study the immune profile of TB patients during treatment and cure.
The cross-sectional study included newly diagnosed pulmonary TB patients and healthy controls. Levels of serum cytokines/chemokines (Th1/Th2/Th17) were measured by BD cytometric bead array. The cell surface markers assessed in the study were CD3, CD4, CD8, CD16, CD56, and BD human regulatory T cell cocktail (CD4/CD25/CD127).
Data analysis observed statistically significant differences in CD3dim/CD56 + natural killer T (NKT) among TB patients with significantly low levels in healthy controls and after treatment completion (P < 0.0001). The analysis also revealed a high percentage of CD3dim/CD56 + NKT in fast responders. The percentage of T regulatory was found to be high in patients when compared with healthy controls; the values were statistically significant (0.0002). Interleukin-6 was significantly associated with the disease (P < 0.0485).
A comprehensive understanding of role of CD3dim/CD56+ NKT in antimycobacterial immunity may enable new possibilities for NK cell-based prophylactic and/or therapeutic strategies against TB.</description><identifier>ISSN: 2212-5531</identifier><identifier>EISSN: 2212-554X</identifier><identifier>DOI: 10.4103/ijmy.ijmy_141_19</identifier><identifier>PMID: 31793502</identifier><language>eng</language><publisher>Netherlands: Medknow Publications and Media Pvt. Ltd</publisher><subject>Care and treatment ; Case-Control Studies ; Cross-Sectional Studies ; Cytokines - blood ; Ethylenediaminetetraacetic acid ; Humans ; Immunophenotyping ; India ; Interleukin-6 - blood ; Medical research ; Medicine, Experimental ; Natural Killer T-Cells - classification ; Natural Killer T-Cells - immunology ; T-Lymphocytes, Regulatory - immunology ; Tuberculosis ; Tuberculosis, Pulmonary - immunology</subject><ispartof>International journal of mycobacteriology, 2019-10, Vol.8 (4), p.333-340</ispartof><rights>COPYRIGHT 2019 Medknow Publications and Media Pvt. Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-a79754a6335ad9377e021d8b215d9524daecb274cca618ea5b9359413514e06a3</citedby><cites>FETCH-LOGICAL-c442t-a79754a6335ad9377e021d8b215d9524daecb274cca618ea5b9359413514e06a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31793502$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pandey, Pooja</creatorcontrib><creatorcontrib>Bhatnagar, Anuj Kumar</creatorcontrib><creatorcontrib>Mohan, Anant</creatorcontrib><creatorcontrib>Sachdeva, Kuldeep Singh</creatorcontrib><creatorcontrib>Vajpayee, Madhu</creatorcontrib><creatorcontrib>Das, Bimal Kumar</creatorcontrib><creatorcontrib>Samantaray, Jyotish Chandra</creatorcontrib><creatorcontrib>Guleria, Randeep</creatorcontrib><creatorcontrib>Singh, Urvashi Balbir</creatorcontrib><title>Insights in tuberculosis immunology: Role of NKT and T regulatory cells</title><title>International journal of mycobacteriology</title><addtitle>Int J Mycobacteriol</addtitle><description>Tuberculosis (TB) control is challenging due to poor drug compliance and emerging resistance. The need of the hour is to determine the prediction of disease cure and relapse. Patients' immune response is crucial to the disease outcome. This study was designed to study the immune profile of TB patients during treatment and cure.
The cross-sectional study included newly diagnosed pulmonary TB patients and healthy controls. Levels of serum cytokines/chemokines (Th1/Th2/Th17) were measured by BD cytometric bead array. The cell surface markers assessed in the study were CD3, CD4, CD8, CD16, CD56, and BD human regulatory T cell cocktail (CD4/CD25/CD127).
Data analysis observed statistically significant differences in CD3dim/CD56 + natural killer T (NKT) among TB patients with significantly low levels in healthy controls and after treatment completion (P < 0.0001). The analysis also revealed a high percentage of CD3dim/CD56 + NKT in fast responders. The percentage of T regulatory was found to be high in patients when compared with healthy controls; the values were statistically significant (0.0002). Interleukin-6 was significantly associated with the disease (P < 0.0485).
A comprehensive understanding of role of CD3dim/CD56+ NKT in antimycobacterial immunity may enable new possibilities for NK cell-based prophylactic and/or therapeutic strategies against TB.</description><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Cross-Sectional Studies</subject><subject>Cytokines - blood</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Humans</subject><subject>Immunophenotyping</subject><subject>India</subject><subject>Interleukin-6 - blood</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Natural Killer T-Cells - classification</subject><subject>Natural Killer T-Cells - immunology</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>Tuberculosis</subject><subject>Tuberculosis, Pulmonary - immunology</subject><issn>2212-5531</issn><issn>2212-554X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkUtLxDAURoMoKurelQTc6GLGPCdTdyI-BkVBR3AX0vS2RtpGkxacf2_qqDhgAnlxvnCTg9A-JWNBCT9xr81iPAyaCqpptoa2GaNsJKV4Xv9dc7qF9mJ8JakpldHJdBNtcaoyLgnbRlezNrrqpYvYtbjrcwi2r310ad80fetrXy1O8YOvAfsS393MsWkLPMcBqr42nQ8LbKGu4y7aKE0dYe973kFPlxfz8-vR7f3V7PzsdmSFYN3IqExJYSacS1NkXCkgjBbTnFFZZJKJwoDNmRLWmgmdgpF5qjMTlEsqgEwM30FHy3vfgn_vIXa6cXGowLTg-6gZZ2SqJKEsoYdLtDI1aNeWvgvGDrg-U0KSbPiMRI3_oVIvoHHWt1C6dL4SOF4JJKaDj64yfYx69viwypIla4OPMUCp34JrTEjKiB4k6i9_fySmyMH3A_u8geI38KOMfwIAFpbA</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Pandey, Pooja</creator><creator>Bhatnagar, Anuj Kumar</creator><creator>Mohan, Anant</creator><creator>Sachdeva, Kuldeep Singh</creator><creator>Vajpayee, Madhu</creator><creator>Das, Bimal Kumar</creator><creator>Samantaray, Jyotish Chandra</creator><creator>Guleria, Randeep</creator><creator>Singh, Urvashi Balbir</creator><general>Medknow Publications and Media Pvt. Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>7X8</scope></search><sort><creationdate>20191001</creationdate><title>Insights in tuberculosis immunology: Role of NKT and T regulatory cells</title><author>Pandey, Pooja ; Bhatnagar, Anuj Kumar ; Mohan, Anant ; Sachdeva, Kuldeep Singh ; Vajpayee, Madhu ; Das, Bimal Kumar ; Samantaray, Jyotish Chandra ; Guleria, Randeep ; Singh, Urvashi Balbir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-a79754a6335ad9377e021d8b215d9524daecb274cca618ea5b9359413514e06a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Care and treatment</topic><topic>Case-Control Studies</topic><topic>Cross-Sectional Studies</topic><topic>Cytokines - blood</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Humans</topic><topic>Immunophenotyping</topic><topic>India</topic><topic>Interleukin-6 - blood</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Natural Killer T-Cells - classification</topic><topic>Natural Killer T-Cells - immunology</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>Tuberculosis</topic><topic>Tuberculosis, Pulmonary - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pandey, Pooja</creatorcontrib><creatorcontrib>Bhatnagar, Anuj Kumar</creatorcontrib><creatorcontrib>Mohan, Anant</creatorcontrib><creatorcontrib>Sachdeva, Kuldeep Singh</creatorcontrib><creatorcontrib>Vajpayee, Madhu</creatorcontrib><creatorcontrib>Das, Bimal Kumar</creatorcontrib><creatorcontrib>Samantaray, Jyotish Chandra</creatorcontrib><creatorcontrib>Guleria, Randeep</creatorcontrib><creatorcontrib>Singh, Urvashi Balbir</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of mycobacteriology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pandey, Pooja</au><au>Bhatnagar, Anuj Kumar</au><au>Mohan, Anant</au><au>Sachdeva, Kuldeep Singh</au><au>Vajpayee, Madhu</au><au>Das, Bimal Kumar</au><au>Samantaray, Jyotish Chandra</au><au>Guleria, Randeep</au><au>Singh, Urvashi Balbir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insights in tuberculosis immunology: Role of NKT and T regulatory cells</atitle><jtitle>International journal of mycobacteriology</jtitle><addtitle>Int J Mycobacteriol</addtitle><date>2019-10-01</date><risdate>2019</risdate><volume>8</volume><issue>4</issue><spage>333</spage><epage>340</epage><pages>333-340</pages><issn>2212-5531</issn><eissn>2212-554X</eissn><abstract>Tuberculosis (TB) control is challenging due to poor drug compliance and emerging resistance. The need of the hour is to determine the prediction of disease cure and relapse. Patients' immune response is crucial to the disease outcome. This study was designed to study the immune profile of TB patients during treatment and cure.
The cross-sectional study included newly diagnosed pulmonary TB patients and healthy controls. Levels of serum cytokines/chemokines (Th1/Th2/Th17) were measured by BD cytometric bead array. The cell surface markers assessed in the study were CD3, CD4, CD8, CD16, CD56, and BD human regulatory T cell cocktail (CD4/CD25/CD127).
Data analysis observed statistically significant differences in CD3dim/CD56 + natural killer T (NKT) among TB patients with significantly low levels in healthy controls and after treatment completion (P < 0.0001). The analysis also revealed a high percentage of CD3dim/CD56 + NKT in fast responders. The percentage of T regulatory was found to be high in patients when compared with healthy controls; the values were statistically significant (0.0002). Interleukin-6 was significantly associated with the disease (P < 0.0485).
A comprehensive understanding of role of CD3dim/CD56+ NKT in antimycobacterial immunity may enable new possibilities for NK cell-based prophylactic and/or therapeutic strategies against TB.</abstract><cop>Netherlands</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><pmid>31793502</pmid><doi>10.4103/ijmy.ijmy_141_19</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2212-5531 |
| ispartof | International journal of mycobacteriology, 2019-10, Vol.8 (4), p.333-340 |
| issn | 2212-5531 2212-554X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2320875012 |
| source | MEDLINE; Medknow Open Access Medical Journals; DOAJ Directory of Open Access Journals |
| subjects | Care and treatment Case-Control Studies Cross-Sectional Studies Cytokines - blood Ethylenediaminetetraacetic acid Humans Immunophenotyping India Interleukin-6 - blood Medical research Medicine, Experimental Natural Killer T-Cells - classification Natural Killer T-Cells - immunology T-Lymphocytes, Regulatory - immunology Tuberculosis Tuberculosis, Pulmonary - immunology |
| title | Insights in tuberculosis immunology: Role of NKT and T regulatory cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T08%3A07%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Insights%20in%20tuberculosis%20immunology:%20Role%20of%20NKT%20and%20T%20regulatory%20cells&rft.jtitle=International%20journal%20of%20mycobacteriology&rft.au=Pandey,%20Pooja&rft.date=2019-10-01&rft.volume=8&rft.issue=4&rft.spage=333&rft.epage=340&rft.pages=333-340&rft.issn=2212-5531&rft.eissn=2212-554X&rft_id=info:doi/10.4103/ijmy.ijmy_141_19&rft_dat=%3Cgale_proqu%3EA745099168%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2320875012&rft_id=info:pmid/31793502&rft_galeid=A745099168&rfr_iscdi=true |