Drug Metabolism by the Mitochondrial Amidoxime Reducing Component (mARC): Rapid Assay and Identification of New Substrates

For the development of new drugs, the investigation of their metabolism is of central importance. In the past, the focus was mostly on the consideration of established enzymes leading to oxidations such as cytochrome P450. However, reductive metabolism by the mARC enzyme system can play an important...

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Veröffentlicht in:	Journal of medicinal chemistry 2020-06, Vol.63 (12), p.6538-6546
Hauptverfasser:	Indorf, Patrick, Kubitza, Christian, Scheidig, Axel J, Kunze, Thomas, Clement, Bernd
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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