Sex specific effects of capsaicin on longevity regulation
The consumption of spicy food in daily diets have been found to be inversely associated with human mortality. However, whether intake of spices is the reason for reduced mortality, and whether capsaicin, the main bioactive component of spices, plays a major role, remain elusive. Here, we report that...
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| Veröffentlicht in: | Experimental gerontology 2020-02, Vol.130, p.110788-110788, Article 110788 |
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| container_title | Experimental gerontology |
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| creator | Shen, Jie Shan, Jianying Zhu, Xiang Yang, Peijing Zhang, Dake Liang, Boying Li, Motao Zang, Xiaohui Dai, Zhuoping |
| description | The consumption of spicy food in daily diets have been found to be inversely associated with human mortality. However, whether intake of spices is the reason for reduced mortality, and whether capsaicin, the main bioactive component of spices, plays a major role, remain elusive. Here, we report that low concentration of capsaicin can indeed extend life span. Capsaicin had no effect on food consumption, reproductive fitness, or stress tolerance. However, it did appear to decrease the daytime activity of females. We hypothesize that this decrease in activity may be a contributing factor in the life span extending property of capsaicin. |
| doi_str_mv | 10.1016/j.exger.2019.110788 |
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However, whether intake of spices is the reason for reduced mortality, and whether capsaicin, the main bioactive component of spices, plays a major role, remain elusive. Here, we report that low concentration of capsaicin can indeed extend life span. Capsaicin had no effect on food consumption, reproductive fitness, or stress tolerance. However, it did appear to decrease the daytime activity of females. 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We hypothesize that this decrease in activity may be a contributing factor in the life span extending property of capsaicin.</description><subject>Animals</subject><subject>Capsaicin</subject><subject>Capsaicin - pharmacology</subject><subject>Diet</subject><subject>Drosophila</subject><subject>Female</subject><subject>Life span</subject><subject>Longevity - drug effects</subject><subject>Male</subject><subject>Sex Characteristics</subject><subject>Sex Factors</subject><subject>Sex specificity</subject><subject>Spices</subject><issn>0531-5565</issn><issn>1873-6815</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDtPwzAUhS0EoqXwC5BQRpYEP-LEGRhQxUuqxADMlmtfV67SONhJ1f57UlIYme7ynXN0P4SuCc4IJsXdOoPdCkJGMakyQnApxAmaElGytBCEn6Ip5oyknBd8gi5iXGOMC8rIOZowUlZYYDZF1TvsktiCdtbpBKwF3cXE20SrNiqnXZP4Jql9s4Kt6_ZJgFVfq8755hKdWVVHuDreGfp8evyYv6SLt-fX-cMi1YxXXaosVzkwDUuOy9xybnJScWEE2JLngAVb5oZWUFHNaVnqQmlrNKYGbKFUVbAZuh172-C_eoid3Liooa5VA76PkjKKRUlyekDZiOrgYwxgZRvcRoW9JFgenMm1_HEmD87k6GxI3RwH-uUGzF_mV9IA3I8ADG9u3RCP2kGjwbgw6JLGu38HvgG07H5D</recordid><startdate>202002</startdate><enddate>202002</enddate><creator>Shen, Jie</creator><creator>Shan, Jianying</creator><creator>Zhu, Xiang</creator><creator>Yang, Peijing</creator><creator>Zhang, Dake</creator><creator>Liang, Boying</creator><creator>Li, Motao</creator><creator>Zang, Xiaohui</creator><creator>Dai, Zhuoping</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202002</creationdate><title>Sex specific effects of capsaicin on longevity regulation</title><author>Shen, Jie ; Shan, Jianying ; Zhu, Xiang ; Yang, Peijing ; Zhang, Dake ; Liang, Boying ; Li, Motao ; Zang, Xiaohui ; Dai, Zhuoping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-af5a4e3ceb5074f55d41958d8ef754e083b4d29e92c5277c6acfdc02def6aa963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Capsaicin</topic><topic>Capsaicin - pharmacology</topic><topic>Diet</topic><topic>Drosophila</topic><topic>Female</topic><topic>Life span</topic><topic>Longevity - drug effects</topic><topic>Male</topic><topic>Sex Characteristics</topic><topic>Sex Factors</topic><topic>Sex specificity</topic><topic>Spices</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shen, Jie</creatorcontrib><creatorcontrib>Shan, Jianying</creatorcontrib><creatorcontrib>Zhu, Xiang</creatorcontrib><creatorcontrib>Yang, Peijing</creatorcontrib><creatorcontrib>Zhang, Dake</creatorcontrib><creatorcontrib>Liang, Boying</creatorcontrib><creatorcontrib>Li, Motao</creatorcontrib><creatorcontrib>Zang, Xiaohui</creatorcontrib><creatorcontrib>Dai, Zhuoping</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental gerontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shen, Jie</au><au>Shan, Jianying</au><au>Zhu, Xiang</au><au>Yang, Peijing</au><au>Zhang, Dake</au><au>Liang, Boying</au><au>Li, Motao</au><au>Zang, Xiaohui</au><au>Dai, Zhuoping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex specific effects of capsaicin on longevity regulation</atitle><jtitle>Experimental gerontology</jtitle><addtitle>Exp Gerontol</addtitle><date>2020-02</date><risdate>2020</risdate><volume>130</volume><spage>110788</spage><epage>110788</epage><pages>110788-110788</pages><artnum>110788</artnum><issn>0531-5565</issn><eissn>1873-6815</eissn><abstract>The consumption of spicy food in daily diets have been found to be inversely associated with human mortality. 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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Capsaicin Capsaicin - pharmacology Diet Drosophila Female Life span Longevity - drug effects Male Sex Characteristics Sex Factors Sex specificity Spices |
| title | Sex specific effects of capsaicin on longevity regulation |
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