The blood-brain barrier: Physiology and strategies for drug delivery

The blood-brain barrier (BBB) is a dynamic structure that functions as a gatekeeper, reflecting the unique requirements of the brain. In this review, following a brief historical overview of how the concepts of the BBB and the neurovascular unit (NVU) developed, we describe its physiology and archit...

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Veröffentlicht in:	Advanced drug delivery reviews 2020, Vol.165-166, p.1-14
Hauptverfasser:	Pandit, Rucha, Chen, Liyu, Götz, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Blood-brain barrier Brain Drug delivery Endothelial cells Focused ultrasound Microbubbles Tight junctions
Online-Zugang:	Volltext
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