Transcription factor early growth response-1 plays an oncogenic role in salivary gland pleomorphic adenoma
Objectives Although abnormal expression of early growth response-1 (Egr1) has been revealed in various human solid tumors, the functions and potential mechanisms of Egr1 in the progression of salivary gland pleomorphic adenoma (SGPA) are not entirely understood. Results An elevated expression of Egr...
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| Veröffentlicht in: | Biotechnology letters 2020-02, Vol.42 (2), p.197-207 |
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| creator | Shen, Shukun Zhu, Yun Lu, Hao Zhang, Chenping Yang, Wenjun Xu, Wanlin |
| description | Objectives
Although abnormal expression of early growth response-1 (Egr1) has been revealed in various human solid tumors, the functions and potential mechanisms of Egr1 in the progression of salivary gland pleomorphic adenoma (SGPA) are not entirely understood.
Results
An elevated expression of Egr1 was observed both in the human salivary gland pleomorphic adenoma tissues and tumor-initiating cell (TIC) cells, when compared with control group. By loss-of-function assay, the proliferation and invasion capacities of TICs were inhibited, while the cell apoptosis was promoted, which were further evidenced by the protein expression analysis of several key apoptosis-related regulators. Furthermore, TICs with Mithramycin A (an Egr1 inhibitor) treatment achieved the same effects of endogenous Egr1 knockdown.
Conclusions
All these data collectively suggest that Egr1 act as an oncogenic factor in salivary gland pleomorphic adenoma, which may be a potential target for the treatment of SGPA. |
| doi_str_mv | 10.1007/s10529-019-02776-1 |
| format | Article |
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Although abnormal expression of early growth response-1 (Egr1) has been revealed in various human solid tumors, the functions and potential mechanisms of Egr1 in the progression of salivary gland pleomorphic adenoma (SGPA) are not entirely understood.
Results
An elevated expression of Egr1 was observed both in the human salivary gland pleomorphic adenoma tissues and tumor-initiating cell (TIC) cells, when compared with control group. By loss-of-function assay, the proliferation and invasion capacities of TICs were inhibited, while the cell apoptosis was promoted, which were further evidenced by the protein expression analysis of several key apoptosis-related regulators. Furthermore, TICs with Mithramycin A (an Egr1 inhibitor) treatment achieved the same effects of endogenous Egr1 knockdown.
Conclusions
All these data collectively suggest that Egr1 act as an oncogenic factor in salivary gland pleomorphic adenoma, which may be a potential target for the treatment of SGPA.</description><identifier>ISSN: 0141-5492</identifier><identifier>EISSN: 1573-6776</identifier><identifier>DOI: 10.1007/s10529-019-02776-1</identifier><identifier>PMID: 31786685</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adenoma ; Apoptosis ; Applied Microbiology ; Biochemistry ; Biomedical and Life Sciences ; Biotechnology ; Cell proliferation ; EGR-1 protein ; Life Sciences ; Microbiology ; Oral cancer ; Original Research Paper ; Regulators ; Salivary gland ; Salivary glands ; Solid tumors ; Tumors</subject><ispartof>Biotechnology letters, 2020-02, Vol.42 (2), p.197-207</ispartof><rights>Springer Nature B.V. 2019</rights><rights>Biotechnology Letters is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-1b2c1cd9208119614ec048faf4cfa4561ff19e9510861fd3e59ec4f889f02acd3</citedby><cites>FETCH-LOGICAL-c412t-1b2c1cd9208119614ec048faf4cfa4561ff19e9510861fd3e59ec4f889f02acd3</cites><orcidid>0000-0003-0052-662X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10529-019-02776-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10529-019-02776-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31786685$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shen, Shukun</creatorcontrib><creatorcontrib>Zhu, Yun</creatorcontrib><creatorcontrib>Lu, Hao</creatorcontrib><creatorcontrib>Zhang, Chenping</creatorcontrib><creatorcontrib>Yang, Wenjun</creatorcontrib><creatorcontrib>Xu, Wanlin</creatorcontrib><title>Transcription factor early growth response-1 plays an oncogenic role in salivary gland pleomorphic adenoma</title><title>Biotechnology letters</title><addtitle>Biotechnol Lett</addtitle><addtitle>Biotechnol Lett</addtitle><description>Objectives
Although abnormal expression of early growth response-1 (Egr1) has been revealed in various human solid tumors, the functions and potential mechanisms of Egr1 in the progression of salivary gland pleomorphic adenoma (SGPA) are not entirely understood.
Results
An elevated expression of Egr1 was observed both in the human salivary gland pleomorphic adenoma tissues and tumor-initiating cell (TIC) cells, when compared with control group. By loss-of-function assay, the proliferation and invasion capacities of TICs were inhibited, while the cell apoptosis was promoted, which were further evidenced by the protein expression analysis of several key apoptosis-related regulators. Furthermore, TICs with Mithramycin A (an Egr1 inhibitor) treatment achieved the same effects of endogenous Egr1 knockdown.
Conclusions
All these data collectively suggest that Egr1 act as an oncogenic factor in salivary gland pleomorphic adenoma, which may be a potential target for the treatment of SGPA.</description><subject>Adenoma</subject><subject>Apoptosis</subject><subject>Applied Microbiology</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Cell proliferation</subject><subject>EGR-1 protein</subject><subject>Life Sciences</subject><subject>Microbiology</subject><subject>Oral cancer</subject><subject>Original Research Paper</subject><subject>Regulators</subject><subject>Salivary gland</subject><subject>Salivary glands</subject><subject>Solid 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factor early growth response-1 plays an oncogenic role in salivary gland pleomorphic adenoma</title><author>Shen, Shukun ; Zhu, Yun ; Lu, Hao ; Zhang, Chenping ; Yang, Wenjun ; Xu, Wanlin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-1b2c1cd9208119614ec048faf4cfa4561ff19e9510861fd3e59ec4f889f02acd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adenoma</topic><topic>Apoptosis</topic><topic>Applied Microbiology</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Cell proliferation</topic><topic>EGR-1 protein</topic><topic>Life Sciences</topic><topic>Microbiology</topic><topic>Oral cancer</topic><topic>Original Research Paper</topic><topic>Regulators</topic><topic>Salivary gland</topic><topic>Salivary glands</topic><topic>Solid tumors</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shen, Shukun</creatorcontrib><creatorcontrib>Zhu, Yun</creatorcontrib><creatorcontrib>Lu, Hao</creatorcontrib><creatorcontrib>Zhang, Chenping</creatorcontrib><creatorcontrib>Yang, Wenjun</creatorcontrib><creatorcontrib>Xu, Wanlin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni 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Lett</stitle><addtitle>Biotechnol Lett</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>42</volume><issue>2</issue><spage>197</spage><epage>207</epage><pages>197-207</pages><issn>0141-5492</issn><eissn>1573-6776</eissn><abstract>Objectives
Although abnormal expression of early growth response-1 (Egr1) has been revealed in various human solid tumors, the functions and potential mechanisms of Egr1 in the progression of salivary gland pleomorphic adenoma (SGPA) are not entirely understood.
Results
An elevated expression of Egr1 was observed both in the human salivary gland pleomorphic adenoma tissues and tumor-initiating cell (TIC) cells, when compared with control group. By loss-of-function assay, the proliferation and invasion capacities of TICs were inhibited, while the cell apoptosis was promoted, which were further evidenced by the protein expression analysis of several key apoptosis-related regulators. Furthermore, TICs with Mithramycin A (an Egr1 inhibitor) treatment achieved the same effects of endogenous Egr1 knockdown.
Conclusions
All these data collectively suggest that Egr1 act as an oncogenic factor in salivary gland pleomorphic adenoma, which may be a potential target for the treatment of SGPA.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>31786685</pmid><doi>10.1007/s10529-019-02776-1</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-0052-662X</orcidid></addata></record> |
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| subjects | Adenoma Apoptosis Applied Microbiology Biochemistry Biomedical and Life Sciences Biotechnology Cell proliferation EGR-1 protein Life Sciences Microbiology Oral cancer Original Research Paper Regulators Salivary gland Salivary glands Solid tumors Tumors |
| title | Transcription factor early growth response-1 plays an oncogenic role in salivary gland pleomorphic adenoma |
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