A mechanistic understanding of compression damage to the dissolubility of coated pellets in tablets

[Display omitted] Damage to the drug diffusion coat barrier of controlled release pellets by the compaction force when preparing multiple-unit pellet system tablets is a major concern. Previous studies have shown that pellets located at the tablet axial and radial peripheral surfaces were more susce...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2020-01, Vol.146, p.93-100
Hauptverfasser:	Hiew, Tze Ning, Tian, Yu Harn, Tan, Huei Ming, Heng, Paul Wan Sia
Format:	Artikel
Sprache:	eng
Schlagworte:	Coat damage Coated pellet Compaction Microcrystalline cellulose Minitablet Sustained release
Online-Zugang:	Volltext
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