Study on forced degradation behaviour of dofetilide by LC-PDA and Q-TOF/MS/MS: Mechanistic explanations of hydrolytic, oxidative and photocatalytic rearrangement of degradation products

[Display omitted] •Forced degradation studies was carried on dofetilide according to ICH Q1A (R2) guidelines.•Eight DPs were identified and separated on RP-HPLC.•Characterization of degradation products using LC-Q-TOF/MS/MS in ESI and APCI positive mode.•Mechanistic explanation and mass fragmentatio...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2020-02, Vol.179, p.112985-112985, Article 112985
Hauptverfasser:	Thalluri, Bhargavi, Dhiman, Vivek, Tiwari, Shristy, Baira, Shandaliya Mahamuni, Kumar Talluri, M.V.N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Characterization Chromatography, High Pressure Liquid - methods Chromatography, Reverse-Phase Degradation products Dofetilide Drug Stability Forced degradation study Hot Temperature HPLC-PDA Hydrolysis LC–MS Molecular Structure Oxidation-Reduction Phenethylamines - chemistry Photolysis Sulfonamides - analysis Sulfonamides - chemistry Tandem Mass Spectrometry - methods
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