Tumor sidedness and efficacy of first-line therapy in patients with RAS/BRAF wild-type metastatic colorectal cancer: A network meta-analysis

•This meta-analysis compares first-line therapy efficacy for KRAS, RAS, BRAF WT mCRC.•Selected RCTs compared chemotherapy plus mAb combination against chemotherapy alone.•SUCRA values were used to identify the best possible therapy in the meta-analysis.•Cetuximab and panitumumab are the most effecti...

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Veröffentlicht in:	Critical reviews in oncology/hematology 2020-01, Vol.145, p.102823-102823, Article 102823
Hauptverfasser:	Wu, Chih-Chien, Wang, Jui-Ho, Lin, Pei-Chin, Liang, Chun-An, Huang, Ching-Ying, Lien, Han-Chu, Chen, Chung-Yu, Chou, Kang-Ju, Su, Yi-Chia
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal Antineoplastic Combined Chemotherapy Protocols Bevacizumab Cetuximab Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Disease-Free Survival First-line therapy Functional Laterality Humans Metastatic colorectal cancer Network Meta-Analysis Proto-Oncogene Proteins B-raf Targeted agents Tumor sidedness
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