Tau-positron emission tomography correlates with neuropathology findings
Comparison of tau (flortaucipir) positron emission tomography (FTP-PET) to autopsy is important to demonstrate the relationship of FTP-PET to neuropathologic findings. Autopsies were performed on 26 participants who had antemortem FTP-PET. FTP-PET standardized uptake value ratios (SUVRs) were compar...
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| Veröffentlicht in: | Alzheimer's & dementia 2020-03, Vol.16 (3), p.561-571 |
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| creator | Lowe, Val J. Lundt, Emily S. Albertson, Sabrina M. Min, Hoon-Ki Fang, Ping Przybelski, Scott A. Senjem, Matthew L. Schwarz, Christopher G. Kantarci, Kejal Boeve, Bradley Jones, David T. Reichard, R. Ross Tranovich, Jessica F. Hanna Al-Shaikh, Fadi S. Knopman, David S. Jack, Clifford R. Dickson, Dennis W. Petersen, Ronald C. Murray, Melissa E. |
| description | Comparison of tau (flortaucipir) positron emission tomography (FTP-PET) to autopsy is important to demonstrate the relationship of FTP-PET to neuropathologic findings.
Autopsies were performed on 26 participants who had antemortem FTP-PET. FTP-PET standardized uptake value ratios (SUVRs) were compared to autopsy diagnoses and Braak tangle stage. Quantitative tau burden was compared to regional FTP-PET signal.
Participants with Braak stages of IV or greater had elevated FTP-PET signal. FTP-PET was elevated in participants with Alzheimer's disease. An FTP-PET SUVR cut point of 1.29 was determined to be optimal. Quantitative measurements of hippocampal and temporal lobe tau burden were highly correlated to FTP-PET signal (rho's from 0.61 to 0.70, P ≤ .02).
Elevated FTP-PET reflects Braak IV or greater neuropathology. Participants with primary age-related tauopathy and hippocampal sclerosis did not show elevated FTP-PET signal. Secondary neuropathologic diagnoses of Alzheimer's disease neuropathologic change can lead to borderline elevated FTP-PET signal. |
| doi_str_mv | 10.1016/j.jalz.2019.09.079 |
| format | Article |
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Autopsies were performed on 26 participants who had antemortem FTP-PET. FTP-PET standardized uptake value ratios (SUVRs) were compared to autopsy diagnoses and Braak tangle stage. Quantitative tau burden was compared to regional FTP-PET signal.
Participants with Braak stages of IV or greater had elevated FTP-PET signal. FTP-PET was elevated in participants with Alzheimer's disease. An FTP-PET SUVR cut point of 1.29 was determined to be optimal. Quantitative measurements of hippocampal and temporal lobe tau burden were highly correlated to FTP-PET signal (rho's from 0.61 to 0.70, P ≤ .02).
Elevated FTP-PET reflects Braak IV or greater neuropathology. Participants with primary age-related tauopathy and hippocampal sclerosis did not show elevated FTP-PET signal. Secondary neuropathologic diagnoses of Alzheimer's disease neuropathologic change can lead to borderline elevated FTP-PET signal.</description><identifier>ISSN: 1552-5260</identifier><identifier>EISSN: 1552-5279</identifier><identifier>DOI: 10.1016/j.jalz.2019.09.079</identifier><identifier>PMID: 31784374</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer Disease - diagnostic imaging ; Alzheimer Disease - metabolism ; Alzheimer Disease - pathology ; Alzheimer's disease ; Autopsy ; Braak tangle stage ; Brain - pathology ; Female ; flortaucipir ; Humans ; Male ; PET ; Positron-Emission Tomography ; Tau ; tau Proteins - metabolism</subject><ispartof>Alzheimer's & dementia, 2020-03, Vol.16 (3), p.561-571</ispartof><rights>2019 the Alzheimer's Association</rights><rights>2019 the Alzheimer's Association.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4491-ab4392c6b61f8c106469f33b3400754aec11a5c0735c3a6520cd0f5d936882c83</citedby><cites>FETCH-LOGICAL-c4491-ab4392c6b61f8c106469f33b3400754aec11a5c0735c3a6520cd0f5d936882c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.jalz.2019.09.079$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2Fj.jalz.2019.09.079$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31784374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lowe, Val J.</creatorcontrib><creatorcontrib>Lundt, Emily S.</creatorcontrib><creatorcontrib>Albertson, Sabrina M.</creatorcontrib><creatorcontrib>Min, Hoon-Ki</creatorcontrib><creatorcontrib>Fang, Ping</creatorcontrib><creatorcontrib>Przybelski, Scott A.</creatorcontrib><creatorcontrib>Senjem, Matthew L.</creatorcontrib><creatorcontrib>Schwarz, Christopher G.</creatorcontrib><creatorcontrib>Kantarci, Kejal</creatorcontrib><creatorcontrib>Boeve, Bradley</creatorcontrib><creatorcontrib>Jones, David T.</creatorcontrib><creatorcontrib>Reichard, R. Ross</creatorcontrib><creatorcontrib>Tranovich, Jessica F.</creatorcontrib><creatorcontrib>Hanna Al-Shaikh, Fadi S.</creatorcontrib><creatorcontrib>Knopman, David S.</creatorcontrib><creatorcontrib>Jack, Clifford R.</creatorcontrib><creatorcontrib>Dickson, Dennis W.</creatorcontrib><creatorcontrib>Petersen, Ronald C.</creatorcontrib><creatorcontrib>Murray, Melissa E.</creatorcontrib><title>Tau-positron emission tomography correlates with neuropathology findings</title><title>Alzheimer's & dementia</title><addtitle>Alzheimers Dement</addtitle><description>Comparison of tau (flortaucipir) positron emission tomography (FTP-PET) to autopsy is important to demonstrate the relationship of FTP-PET to neuropathologic findings.
Autopsies were performed on 26 participants who had antemortem FTP-PET. FTP-PET standardized uptake value ratios (SUVRs) were compared to autopsy diagnoses and Braak tangle stage. Quantitative tau burden was compared to regional FTP-PET signal.
Participants with Braak stages of IV or greater had elevated FTP-PET signal. FTP-PET was elevated in participants with Alzheimer's disease. An FTP-PET SUVR cut point of 1.29 was determined to be optimal. Quantitative measurements of hippocampal and temporal lobe tau burden were highly correlated to FTP-PET signal (rho's from 0.61 to 0.70, P ≤ .02).
Elevated FTP-PET reflects Braak IV or greater neuropathology. Participants with primary age-related tauopathy and hippocampal sclerosis did not show elevated FTP-PET signal. Secondary neuropathologic diagnoses of Alzheimer's disease neuropathologic change can lead to borderline elevated FTP-PET signal.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - diagnostic imaging</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer's disease</subject><subject>Autopsy</subject><subject>Braak tangle stage</subject><subject>Brain - pathology</subject><subject>Female</subject><subject>flortaucipir</subject><subject>Humans</subject><subject>Male</subject><subject>PET</subject><subject>Positron-Emission Tomography</subject><subject>Tau</subject><subject>tau Proteins - metabolism</subject><issn>1552-5260</issn><issn>1552-5279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtLxDAUhYMovv-AC-nSTcebV5uCGxFfMOBGN25CJr2dydBpatIq4683w6hLEQ7cuzjncPgIOaMwoUCLy-VkadrPCQNaTSCprHbIIZWS5ZKV1e7vX8ABOYpxCSBAUblPDjgtleClOCQPz2bMex_dEHyX4crF6NIz-JWfB9Mv1pn1IWBrBozZhxsWWYdj8L0ZFr7183XWuK523TyekL3GtBFPv-8xebm7fb55yKdP948319PcClHR3MwEr5gtZgVtlKVQiKJqOJ9xAVBKYdBSaqSFkkvLTSEZ2BoaWVe8UIpZxY_Jxba3D_5txDjotNli25oO_Rg14wy4AqXKZGVbqw0-xoCN7oNbmbDWFPSGoF7qDUG9IaghqaxS6Py7f5ytsP6N_CBLBrU1fLgW1_-o1NfTV8pA0BS92kYxAXp3GHS0DjuLtQtoB11799e0L7Z5k_o</recordid><startdate>202003</startdate><enddate>202003</enddate><creator>Lowe, Val J.</creator><creator>Lundt, Emily S.</creator><creator>Albertson, Sabrina M.</creator><creator>Min, Hoon-Ki</creator><creator>Fang, Ping</creator><creator>Przybelski, Scott A.</creator><creator>Senjem, Matthew L.</creator><creator>Schwarz, Christopher G.</creator><creator>Kantarci, Kejal</creator><creator>Boeve, Bradley</creator><creator>Jones, David T.</creator><creator>Reichard, R. 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Ross ; Tranovich, Jessica F. ; Hanna Al-Shaikh, Fadi S. ; Knopman, David S. ; Jack, Clifford R. ; Dickson, Dennis W. ; Petersen, Ronald C. ; Murray, Melissa E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4491-ab4392c6b61f8c106469f33b3400754aec11a5c0735c3a6520cd0f5d936882c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - diagnostic imaging</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer's disease</topic><topic>Autopsy</topic><topic>Braak tangle stage</topic><topic>Brain - pathology</topic><topic>Female</topic><topic>flortaucipir</topic><topic>Humans</topic><topic>Male</topic><topic>PET</topic><topic>Positron-Emission Tomography</topic><topic>Tau</topic><topic>tau Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lowe, Val J.</creatorcontrib><creatorcontrib>Lundt, Emily S.</creatorcontrib><creatorcontrib>Albertson, Sabrina M.</creatorcontrib><creatorcontrib>Min, Hoon-Ki</creatorcontrib><creatorcontrib>Fang, Ping</creatorcontrib><creatorcontrib>Przybelski, Scott A.</creatorcontrib><creatorcontrib>Senjem, Matthew L.</creatorcontrib><creatorcontrib>Schwarz, Christopher G.</creatorcontrib><creatorcontrib>Kantarci, Kejal</creatorcontrib><creatorcontrib>Boeve, Bradley</creatorcontrib><creatorcontrib>Jones, David T.</creatorcontrib><creatorcontrib>Reichard, R. Ross</creatorcontrib><creatorcontrib>Tranovich, Jessica F.</creatorcontrib><creatorcontrib>Hanna Al-Shaikh, Fadi S.</creatorcontrib><creatorcontrib>Knopman, David S.</creatorcontrib><creatorcontrib>Jack, Clifford R.</creatorcontrib><creatorcontrib>Dickson, Dennis W.</creatorcontrib><creatorcontrib>Petersen, Ronald C.</creatorcontrib><creatorcontrib>Murray, Melissa E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alzheimer's & dementia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lowe, Val J.</au><au>Lundt, Emily S.</au><au>Albertson, Sabrina M.</au><au>Min, Hoon-Ki</au><au>Fang, Ping</au><au>Przybelski, Scott A.</au><au>Senjem, Matthew L.</au><au>Schwarz, Christopher G.</au><au>Kantarci, Kejal</au><au>Boeve, Bradley</au><au>Jones, David T.</au><au>Reichard, R. Ross</au><au>Tranovich, Jessica F.</au><au>Hanna Al-Shaikh, Fadi S.</au><au>Knopman, David S.</au><au>Jack, Clifford R.</au><au>Dickson, Dennis W.</au><au>Petersen, Ronald C.</au><au>Murray, Melissa E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tau-positron emission tomography correlates with neuropathology findings</atitle><jtitle>Alzheimer's & dementia</jtitle><addtitle>Alzheimers Dement</addtitle><date>2020-03</date><risdate>2020</risdate><volume>16</volume><issue>3</issue><spage>561</spage><epage>571</epage><pages>561-571</pages><issn>1552-5260</issn><eissn>1552-5279</eissn><abstract>Comparison of tau (flortaucipir) positron emission tomography (FTP-PET) to autopsy is important to demonstrate the relationship of FTP-PET to neuropathologic findings.
Autopsies were performed on 26 participants who had antemortem FTP-PET. FTP-PET standardized uptake value ratios (SUVRs) were compared to autopsy diagnoses and Braak tangle stage. Quantitative tau burden was compared to regional FTP-PET signal.
Participants with Braak stages of IV or greater had elevated FTP-PET signal. FTP-PET was elevated in participants with Alzheimer's disease. An FTP-PET SUVR cut point of 1.29 was determined to be optimal. Quantitative measurements of hippocampal and temporal lobe tau burden were highly correlated to FTP-PET signal (rho's from 0.61 to 0.70, P ≤ .02).
Elevated FTP-PET reflects Braak IV or greater neuropathology. Participants with primary age-related tauopathy and hippocampal sclerosis did not show elevated FTP-PET signal. Secondary neuropathologic diagnoses of Alzheimer's disease neuropathologic change can lead to borderline elevated FTP-PET signal.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>31784374</pmid><doi>10.1016/j.jalz.2019.09.079</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Alzheimer Disease - diagnostic imaging Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Autopsy Braak tangle stage Brain - pathology Female flortaucipir Humans Male PET Positron-Emission Tomography Tau tau Proteins - metabolism |
| title | Tau-positron emission tomography correlates with neuropathology findings |
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