Patterns of Dynamics Comprise a Conserved Evolutionary Trait

The importance of protein dynamics in function may suggest an evolutionary selection on large-scale protein motions. Here we systematically studied the dynamic characteristics in 2221 protein domains (58477 sequences) of the Pfam database. We defined the patterns of dynamics (PODs) based on the esti...

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Veröffentlicht in:	Journal of molecular biology 2020-01, Vol.432 (2), p.497-507
Hauptverfasser:	Zsolyomi, F., Ambrus, V., Fuxreiter, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Divergent sequences Evolutionary relationship Intrinsically disordered proteins Protein dynamics Structure conservation
Online-Zugang:	Volltext
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