Towards a generic method for ion chromatography/mass spectrometry of low‐molecular‐weight amines in pharmaceutical drug discovery and development

Rationale Low‐molecular‐weight amines are encountered in pharmaceutical analysis, e.g. as reactants in chemical syntheses, but are challenging to analyse using ultrahigh‐performance liquid chromatography/mass spectrometry (UHPLC/MS) due to their high polarity causing poor retention. Ion chromatograp...

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Veröffentlicht in:	Rapid communications in mass spectrometry 2020-09, Vol.34 (S4), p.e8680-n/a
Hauptverfasser:	Lewis, Zoe, Jackson, Bethany A., Crampton, Alex, Ray, Andrew D., Holman, Stephen W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Acetonitrile Acids Additives Amines Chemical bonds Chromatography Elution Ethanol Formic acid Hydrogen bonding Ionization Ions Liquid chromatography Mass spectrometry Methanesulfonic acid Optimization Pharmaceuticals Polarity Positive ions Quadrupoles Scientific imaging Separation Solvents Spectroscopy
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