Biglycan regulates neuroinflammation by promoting M1 microglial activation in early brain injury after experimental subarachnoid hemorrhage

Neuroinflammation can be caused by various factors in early brain injury after subarachnoid hemorrhage (SAH). One of the most important features of this process is M1 microglial activation. In turn, the TLR4/NF‐κB pathway plays an essential role in activating M1 phenotypic microglia. Biglycan, a sma...

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Veröffentlicht in:	Journal of neurochemistry 2020-02, Vol.152 (3), p.368-380
Hauptverfasser:	Xie, Yuke, Peng, Jianhua, Pang, Jinwei, Guo, Kecheng, Zhang, Lifang, Yin, Shigang, Zhou, Jian, Gu, Long, Tu, Tianqi, Mu, Qiancheng, Liao, Yuyan, Zhang, Xianhui, Chen, Ligang, Jiang, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneurysms biglycan Brain Brain injury Cardiovascular system CD16 antigen CD86 antigen Cell activation Cytokines early brain injury Enzyme-linked immunosorbent assay Flow cytometry Head injuries Hemorrhage Immunofluorescence In vivo methods and tests Inflammation Leucine Macrophages Microglia neuroinflammation Nitric oxide Nitric-oxide synthase Pathogenesis Proteoglycans Signal transduction Stroke Subarachnoid hemorrhage TLR2 protein TLR4 TLR4 protein Toll-like receptors Traumatic brain injury Tumor necrosis factor
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