Ultrastructural Organization of Uveal Melanoma Stromal Cells
Typical blood capillaries and vessels in uveal melanoma were shown and different types of uveal melanoma stromal cells were determined by electron microscopy and immunohistochemical analysis. Macrophages, fibroblasts of varying degrees of differentiation and endothelial-like cells with numerous cave...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2019-12, Vol.168 (2), p.285-290 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Bgatova, N. P. Makarova, V. V. Taskaeva, Yu. S. Nogovitsina, S. R. Toporkov, I. A. Eremina, A. V. Trunov, A. N. Chernykh, V. V. |
| description | Typical blood capillaries and vessels in uveal melanoma were shown and different types of uveal melanoma stromal cells were determined by electron microscopy and immunohistochemical analysis. Macrophages, fibroblasts of varying degrees of differentiation and endothelial-like cells with numerous caveolae in the cytoplasm were found in the channels of the extracellular matrix surrounding accumulations of tumor cells. The presence local structures positively stained for markers of the blood and lymphatic vessels (CD31 and podoplanin) in channels of the extracellular matrix suggests that the described endothelial-like cells can be the structural basis for blood and lymphatic vessels of the tumor. |
| doi_str_mv | 10.1007/s10517-019-04692-w |
| format | Article |
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P.</creatorcontrib><creatorcontrib>Makarova, V. V.</creatorcontrib><creatorcontrib>Taskaeva, Yu. S.</creatorcontrib><creatorcontrib>Nogovitsina, S. R.</creatorcontrib><creatorcontrib>Toporkov, I. A.</creatorcontrib><creatorcontrib>Eremina, A. V.</creatorcontrib><creatorcontrib>Trunov, A. N.</creatorcontrib><creatorcontrib>Chernykh, V. V.</creatorcontrib><title>Ultrastructural Organization of Uveal Melanoma Stromal Cells</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>Typical blood capillaries and vessels in uveal melanoma were shown and different types of uveal melanoma stromal cells were determined by electron microscopy and immunohistochemical analysis. Macrophages, fibroblasts of varying degrees of differentiation and endothelial-like cells with numerous caveolae in the cytoplasm were found in the channels of the extracellular matrix surrounding accumulations of tumor cells. The presence local structures positively stained for markers of the blood and lymphatic vessels (CD31 and podoplanin) in channels of the extracellular matrix suggests that the described endothelial-like cells can be the structural basis for blood and lymphatic vessels of the tumor.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Biomarkers, Tumor</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Cell Differentiation - physiology</subject><subject>Endothelial Cells - cytology</subject><subject>Endothelium</subject><subject>Extracellular Matrix - metabolism</subject><subject>Female</subject><subject>Fibroblasts - cytology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Lymphatic Vessels - cytology</subject><subject>Macrophages - cytology</subject><subject>Melanoma</subject><subject>Melanoma - pathology</subject><subject>Melanoma - ultrastructure</subject><subject>Microscopy, Electron</subject><subject>Middle Aged</subject><subject>Pathology</subject><subject>Stromal Cells - ultrastructure</subject><subject>Uvea - blood supply</subject><subject>Uvea - cytology</subject><subject>Uvea - pathology</subject><subject>Uveal Neoplasms - pathology</subject><subject>Uveal Neoplasms - ultrastructure</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVFLIzEUhYMotqv-gX1YBhaWfRm9SZpJAr5IcVVQfNA-hzRN2imZSU1mlPXXb-qoKCySh0tuvnPJPQeh7xiOMQA_SRgY5iVgWcKkkqR82kFjzDgtBSF4F40hU-VECDFC31Jab69Q4X00opgLAsDG6HTmu6hTF3vT9VH74jYudVs_664ObRFcMXu0uXtjvW5Do4u7Lubii6n1Ph2iPad9skev9QDN_pzfTy_L69uLq-nZdWmorLrSOG0IaEIlodyBY4xJbmDOpTZcu_mCcTIRWuBKTrS1kNkFo5Vj4DBzfE4P0O9h7iaGh96mTjV1MvkHurWhT4pQApRXQtKM_hzQpfZW1a0LeT2zxdVZhVklMQGRqeP_UPksbFOb0FpX5_4nwa8PglW2pFul4PutS-kzSAbQxJBStE5tYt3o-FdhUNvU1JCayqmpl9TUUxb9eN2vnzd28S55iykDdABSfmqXNqp16GObPf9q7D_RU6BK</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Bgatova, N. P.</creator><creator>Makarova, V. V.</creator><creator>Taskaeva, Yu. S.</creator><creator>Nogovitsina, S. R.</creator><creator>Toporkov, I. A.</creator><creator>Eremina, A. V.</creator><creator>Trunov, A. N.</creator><creator>Chernykh, V. V.</creator><general>Springer US</general><general>Springer</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20191201</creationdate><title>Ultrastructural Organization of Uveal Melanoma Stromal Cells</title><author>Bgatova, N. P. ; Makarova, V. V. ; Taskaeva, Yu. S. ; Nogovitsina, S. R. ; Toporkov, I. A. ; Eremina, A. V. ; Trunov, A. N. ; Chernykh, V. 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V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultrastructural Organization of Uveal Melanoma Stromal Cells</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2019-12-01</date><risdate>2019</risdate><volume>168</volume><issue>2</issue><spage>285</spage><epage>290</epage><pages>285-290</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><abstract>Typical blood capillaries and vessels in uveal melanoma were shown and different types of uveal melanoma stromal cells were determined by electron microscopy and immunohistochemical analysis. Macrophages, fibroblasts of varying degrees of differentiation and endothelial-like cells with numerous caveolae in the cytoplasm were found in the channels of the extracellular matrix surrounding accumulations of tumor cells. 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| subjects | Aged Aged, 80 and over Analysis Biomarkers, Tumor Biomedical and Life Sciences Biomedicine Cell Biology Cell Differentiation - physiology Endothelial Cells - cytology Endothelium Extracellular Matrix - metabolism Female Fibroblasts - cytology Humans Immunohistochemistry Internal Medicine Laboratory Medicine Lymphatic Vessels - cytology Macrophages - cytology Melanoma Melanoma - pathology Melanoma - ultrastructure Microscopy, Electron Middle Aged Pathology Stromal Cells - ultrastructure Uvea - blood supply Uvea - cytology Uvea - pathology Uveal Neoplasms - pathology Uveal Neoplasms - ultrastructure |
| title | Ultrastructural Organization of Uveal Melanoma Stromal Cells |
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