Absence of bovine leukemia virus proviral DNA in Japanese human blood cell lines and human cancer cell lines
Bovine leukemia virus (BLV) infects cattle worldwide and causes B-cell lymphoma in cattle. BLV has been identified in human breast and lung cancer and in blood, but the association of BLV and human cancer is controversial. In this study, we investigated the existence of BLV in 145 Japanese human blo...
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| Veröffentlicht in: | Archives of virology 2020, Vol.165 (1), p.207-214 |
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| creator | Saito, Susumu Kitamura-Muramatsu, Yuri Komine, Fumiko Polat, Meripet Takeshima, Shin-nosuke Takei, Masami Aida, Yoko |
| description | Bovine leukemia virus (BLV) infects cattle worldwide and causes B-cell lymphoma in cattle. BLV has been identified in human breast and lung cancer and in blood, but the association of BLV and human cancer is controversial. In this study, we investigated the existence of BLV in 145 Japanese human blood cell lines and 54 human cancer cell lines, using a new highly sensitive PCR assay that can amplify even one copy of BLV using LTR primers different from those in previous studies on BLV provirus in breast cancer. All samples were found negative for BLV provirus, suggesting that BLV is unlikely to infect humans. |
| doi_str_mv | 10.1007/s00705-019-04474-9 |
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BLV has been identified in human breast and lung cancer and in blood, but the association of BLV and human cancer is controversial. In this study, we investigated the existence of BLV in 145 Japanese human blood cell lines and 54 human cancer cell lines, using a new highly sensitive PCR assay that can amplify even one copy of BLV using LTR primers different from those in previous studies on BLV provirus in breast cancer. All samples were found negative for BLV provirus, suggesting that BLV is unlikely to infect humans.</description><identifier>ISSN: 0304-8608</identifier><identifier>EISSN: 1432-8798</identifier><identifier>DOI: 10.1007/s00705-019-04474-9</identifier><identifier>PMID: 31776677</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Adult ; Aged ; Animals ; B-cell lymphoma ; Biomedical and Life Sciences ; Biomedicine ; Blood ; Blood Cells - cytology ; Blood Cells - virology ; Bovine leukosis ; Breast cancer ; Brief Report ; Cancer ; Cattle ; Cell Line ; Cell Line, Tumor - cytology ; Cell Line, Tumor - virology ; Female ; Humans ; Infectious Diseases ; Japan ; Leukemia ; Leukemia Virus, Bovine - genetics ; Leukemia Virus, Bovine - isolation & purification ; Lung cancer ; Lymphocytes B ; Male ; Medical Microbiology ; Middle Aged ; Polymerase Chain Reaction ; Sensitivity and Specificity ; Terminal Repeat Sequences ; Tumor cell lines ; Virology ; Young Adult ; Zoonoses - diagnosis ; Zoonoses - virology</subject><ispartof>Archives of virology, 2020, Vol.165 (1), p.207-214</ispartof><rights>Springer-Verlag GmbH Austria, part of Springer Nature 2019</rights><rights>Archives of Virology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-638c9dc343c6cfab28034f883801e4bb5647724253438a44a8a276ae69ca8b543</citedby><cites>FETCH-LOGICAL-c375t-638c9dc343c6cfab28034f883801e4bb5647724253438a44a8a276ae69ca8b543</cites><orcidid>0000-0001-7400-3587</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00705-019-04474-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00705-019-04474-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31776677$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saito, Susumu</creatorcontrib><creatorcontrib>Kitamura-Muramatsu, Yuri</creatorcontrib><creatorcontrib>Komine, Fumiko</creatorcontrib><creatorcontrib>Polat, Meripet</creatorcontrib><creatorcontrib>Takeshima, Shin-nosuke</creatorcontrib><creatorcontrib>Takei, Masami</creatorcontrib><creatorcontrib>Aida, Yoko</creatorcontrib><title>Absence of bovine leukemia virus proviral DNA in Japanese human blood cell lines and human cancer cell lines</title><title>Archives of virology</title><addtitle>Arch Virol</addtitle><addtitle>Arch Virol</addtitle><description>Bovine leukemia virus (BLV) infects cattle worldwide and causes B-cell lymphoma in cattle. BLV has been identified in human breast and lung cancer and in blood, but the association of BLV and human cancer is controversial. In this study, we investigated the existence of BLV in 145 Japanese human blood cell lines and 54 human cancer cell lines, using a new highly sensitive PCR assay that can amplify even one copy of BLV using LTR primers different from those in previous studies on BLV provirus in breast cancer. All samples were found negative for BLV provirus, suggesting that BLV is unlikely to infect humans.</description><subject>Adult</subject><subject>Aged</subject><subject>Animals</subject><subject>B-cell lymphoma</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood</subject><subject>Blood Cells - cytology</subject><subject>Blood Cells - virology</subject><subject>Bovine leukosis</subject><subject>Breast cancer</subject><subject>Brief Report</subject><subject>Cancer</subject><subject>Cattle</subject><subject>Cell Line</subject><subject>Cell Line, Tumor - cytology</subject><subject>Cell Line, Tumor - virology</subject><subject>Female</subject><subject>Humans</subject><subject>Infectious Diseases</subject><subject>Japan</subject><subject>Leukemia</subject><subject>Leukemia Virus, Bovine - genetics</subject><subject>Leukemia Virus, Bovine - isolation & purification</subject><subject>Lung cancer</subject><subject>Lymphocytes B</subject><subject>Male</subject><subject>Medical Microbiology</subject><subject>Middle Aged</subject><subject>Polymerase Chain Reaction</subject><subject>Sensitivity and Specificity</subject><subject>Terminal Repeat Sequences</subject><subject>Tumor cell lines</subject><subject>Virology</subject><subject>Young Adult</subject><subject>Zoonoses - 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BLV has been identified in human breast and lung cancer and in blood, but the association of BLV and human cancer is controversial. In this study, we investigated the existence of BLV in 145 Japanese human blood cell lines and 54 human cancer cell lines, using a new highly sensitive PCR assay that can amplify even one copy of BLV using LTR primers different from those in previous studies on BLV provirus in breast cancer. All samples were found negative for BLV provirus, suggesting that BLV is unlikely to infect humans.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>31776677</pmid><doi>10.1007/s00705-019-04474-9</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7400-3587</orcidid></addata></record> |
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| ispartof | Archives of virology, 2020, Vol.165 (1), p.207-214 |
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| subjects | Adult Aged Animals B-cell lymphoma Biomedical and Life Sciences Biomedicine Blood Blood Cells - cytology Blood Cells - virology Bovine leukosis Breast cancer Brief Report Cancer Cattle Cell Line Cell Line, Tumor - cytology Cell Line, Tumor - virology Female Humans Infectious Diseases Japan Leukemia Leukemia Virus, Bovine - genetics Leukemia Virus, Bovine - isolation & purification Lung cancer Lymphocytes B Male Medical Microbiology Middle Aged Polymerase Chain Reaction Sensitivity and Specificity Terminal Repeat Sequences Tumor cell lines Virology Young Adult Zoonoses - diagnosis Zoonoses - virology |
| title | Absence of bovine leukemia virus proviral DNA in Japanese human blood cell lines and human cancer cell lines |
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