Cell-free chromatin: A newly described mediator of systemic inflammation
Recent research has shown that cell-free chromatin (cfCh) particles that are released from the billions of cells that die in the body everyday can enter into healthy cells, integrate into their genomes and induce dsDNA breaks and apoptotic responses. Genomic integration of cfCh activates NF κ B sugg...
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| Veröffentlicht in: | Journal of biosciences 2019-06, Vol.44 (2), p.1-6, Article 32 |
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| container_title | Journal of biosciences |
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| creator | Chaudhary, Shahid Mittra, Indraneel |
| description | Recent research has shown that cell-free chromatin (cfCh) particles that are released from the billions of cells that die in the body everyday can enter into healthy cells, integrate into their genomes and induce dsDNA breaks and apoptotic responses. Genomic integration of cfCh activates NF
κ
B suggesting a novel mechanism of induction of systemic inflammation. Since DNA damage and inflammation are underlying pathologies in multiple devastating acute and chronic disease conditions, the discovery of agents that can inactivate cfCh may provide therapeutic possibilities. |
| doi_str_mv | 10.1007/s12038-019-9849-7 |
| format | Article |
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Since DNA damage and inflammation are underlying pathologies in multiple devastating acute and chronic disease conditions, the discovery of agents that can inactivate cfCh may provide therapeutic possibilities.</description><subject>Apoptosis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Cells</subject><subject>Chromatin</subject><subject>Chronic illnesses</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA damage</subject><subject>Genomes</subject><subject>Inflammation</subject><subject>Life Sciences</subject><subject>Microbiology</subject><subject>NF-κB protein</subject><subject>Plant Sciences</subject><subject>Review</subject><subject>Zoology</subject><issn>0250-5991</issn><issn>0973-7138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kE1LAzEURYMotlZ_gBsJuHETfUlmJom7UtQKBTe6Dpkko1PmoyYzSP-9KfUDBFcJ5Nyb9w5C5xSuKYC4iZQBlwSoIkpmiogDNAUlOBGUy8N0ZzmQXCk6QScxriGBGYdjNOGUSoAsn6LlwjcNqYL32L6FvjVD3d3iOe78R7PFzkcb6tI73HpXm6EPuK9w3MbBt7XFdVc1pt1l-u4UHVWmif7s65yhl_u758WSrJ4eHhfzFbFcsIEUXEhDgUHpeJWzTJVFBUIok0FpGXNO5pl3uSkLx0oKlnFHnc0BCpC-NIrP0NW-dxP699HHQbd1tGkJ0_l-jJrxtKTiUrCEXv5B1_0YujSdZgzyrCiooomie8qGPsbgK70JdWvCVlPQO816r1kne3qnWYuUufhqHstk5ifx7TUBbA_E9NS9-vD79f-tn0Ghhos</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Chaudhary, Shahid</creator><creator>Mittra, Indraneel</creator><general>Springer India</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H99</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.F</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20190601</creationdate><title>Cell-free chromatin: A newly described mediator of systemic inflammation</title><author>Chaudhary, Shahid ; 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| source | Indian Academy of Sciences; EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings |
| subjects | Apoptosis Biomedical and Life Sciences Biomedicine Cell Biology Cells Chromatin Chronic illnesses Deoxyribonucleic acid DNA DNA damage Genomes Inflammation Life Sciences Microbiology NF-κB protein Plant Sciences Review Zoology |
| title | Cell-free chromatin: A newly described mediator of systemic inflammation |
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