Analysis of TGCA data reveals genetic and epigenetic changes and biological function of MUC family genes in colorectal cancer

Few studies focused on functions and regulatory networks of family members in colorectal cancer based on comprehensive analysis of online database. Copy number variation, methylation, pathway analysis and drug influence on expression were analyzed based on The Cancer Genome Atlas and GTEx database. Copy number variation analysis showed heterozygous amplification and heterozygous deletion predominate. Methylation of , and were found related to gene expression. Function of MUC family genes mainly affects pathways such as apoptosis, cell cycle, DNA damage and EMT pathways. PLX4720, dabrafenib, gefitinib, afatinib and austocystin D can alter the expression of gene. The genetic and epigenetic changes of are related to the level of expression in colorectal cancer.