Isolation, structure elucidation, tyrosinase inhibitory, and antioxidant evaluation of the constituents from Angelica dahurica roots
Two undescribed phenolic compounds, angelicols A ( 1 ) and B ( 2 ) and one undescribed coumarin rhamnoside, angelicoside A ( 3 ), together with 17 known compounds ( 4 – 20 ) were isolated from the roots of Angelica dahurica . Their structures were characterized by physical data analyses such as NMR,...
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| Veröffentlicht in: | Journal of natural medicines 2020-03, Vol.74 (2), p.456-462 |
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| container_title | Journal of natural medicines |
| container_volume | 74 |
| creator | Shu, Penghua Li, Junping Fei, Yingying Zhu, Huiqing Yu, Mengzhu Liu, Anqi Niu, Haoying Zou, Simin Wei, Xialan Ju, Zhiyu Xu, Zhihong |
| description | Two undescribed phenolic compounds, angelicols A (
1
) and B (
2
) and one undescribed coumarin rhamnoside, angelicoside A (
3
), together with 17 known compounds (
4
–
20
) were isolated from the roots of
Angelica dahurica
. Their structures were characterized by physical data analyses such as NMR, HRESIMS, and X-ray diffraction. Compounds
2
,
3
,
5
,
6
and L-ascorbic acid (positive control) exhibited obvious DPPH radical scavenging activities with IC
50
values of 0.36 mM, 0.43 mM, 0.39 mM, 0.44 mM, 0.25 mM, respectively. At a concentration of 25 μM, all compounds showed weaker tyrosinase inhibition activities (%inhibition |
| doi_str_mv | 10.1007/s11418-019-01375-8 |
| format | Article |
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1
) and B (
2
) and one undescribed coumarin rhamnoside, angelicoside A (
3
), together with 17 known compounds (
4
–
20
) were isolated from the roots of
Angelica dahurica
. Their structures were characterized by physical data analyses such as NMR, HRESIMS, and X-ray diffraction. Compounds
2
,
3
,
5
,
6
and L-ascorbic acid (positive control) exhibited obvious DPPH radical scavenging activities with IC
50
values of 0.36 mM, 0.43 mM, 0.39 mM, 0.44 mM, 0.25 mM, respectively. At a concentration of 25 μM, all compounds showed weaker tyrosinase inhibition activities (%inhibition < 5%) than kojic acid (26.00 ± 0.67%, IC
50
= 44.29 ± 0.06 μM).</description><identifier>ISSN: 1340-3443</identifier><identifier>EISSN: 1861-0293</identifier><identifier>DOI: 10.1007/s11418-019-01375-8</identifier><identifier>PMID: 31773388</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Angelica - chemistry ; Angelica dahurica ; Antioxidants ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Ascorbic acid ; Biomedical and Life Sciences ; Biomedicine ; Complementary & Alternative Medicine ; Coumarin ; Coumarins - chemistry ; Kojic acid ; Medicinal Chemistry ; Monophenol Monooxygenase - metabolism ; NMR ; Nuclear magnetic resonance ; Organic chemicals ; Pharmacology/Toxicology ; Pharmacy ; Phenolic compounds ; Plant Roots - chemistry ; Plant Sciences ; Roots ; Vitamin C ; X-ray diffraction</subject><ispartof>Journal of natural medicines, 2020-03, Vol.74 (2), p.456-462</ispartof><rights>The Japanese Society of Pharmacognosy 2019</rights><rights>2019© The Japanese Society of Pharmacognosy 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-12dd932ac2a4d4d3d005d5af7283f2932ea3e0d1ac1c28396a9d23ee95965bb93</citedby><cites>FETCH-LOGICAL-c426t-12dd932ac2a4d4d3d005d5af7283f2932ea3e0d1ac1c28396a9d23ee95965bb93</cites><orcidid>0000-0003-3793-6198 ; 0000-0001-6018-8429</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11418-019-01375-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11418-019-01375-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31773388$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shu, Penghua</creatorcontrib><creatorcontrib>Li, Junping</creatorcontrib><creatorcontrib>Fei, Yingying</creatorcontrib><creatorcontrib>Zhu, Huiqing</creatorcontrib><creatorcontrib>Yu, Mengzhu</creatorcontrib><creatorcontrib>Liu, Anqi</creatorcontrib><creatorcontrib>Niu, Haoying</creatorcontrib><creatorcontrib>Zou, Simin</creatorcontrib><creatorcontrib>Wei, Xialan</creatorcontrib><creatorcontrib>Ju, Zhiyu</creatorcontrib><creatorcontrib>Xu, Zhihong</creatorcontrib><title>Isolation, structure elucidation, tyrosinase inhibitory, and antioxidant evaluation of the constituents from Angelica dahurica roots</title><title>Journal of natural medicines</title><addtitle>J Nat Med</addtitle><addtitle>J Nat Med</addtitle><description>Two undescribed phenolic compounds, angelicols A (
1
) and B (
2
) and one undescribed coumarin rhamnoside, angelicoside A (
3
), together with 17 known compounds (
4
–
20
) were isolated from the roots of
Angelica dahurica
. Their structures were characterized by physical data analyses such as NMR, HRESIMS, and X-ray diffraction. Compounds
2
,
3
,
5
,
6
and L-ascorbic acid (positive control) exhibited obvious DPPH radical scavenging activities with IC
50
values of 0.36 mM, 0.43 mM, 0.39 mM, 0.44 mM, 0.25 mM, respectively. At a concentration of 25 μM, all compounds showed weaker tyrosinase inhibition activities (%inhibition < 5%) than kojic acid (26.00 ± 0.67%, IC
50
= 44.29 ± 0.06 μM).</description><subject>Angelica - chemistry</subject><subject>Angelica dahurica</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Antioxidants - therapeutic use</subject><subject>Ascorbic acid</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Complementary & Alternative Medicine</subject><subject>Coumarin</subject><subject>Coumarins - chemistry</subject><subject>Kojic acid</subject><subject>Medicinal Chemistry</subject><subject>Monophenol Monooxygenase - metabolism</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Organic chemicals</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Phenolic compounds</subject><subject>Plant Roots - chemistry</subject><subject>Plant Sciences</subject><subject>Roots</subject><subject>Vitamin C</subject><subject>X-ray diffraction</subject><issn>1340-3443</issn><issn>1861-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kbtOXDEQhq0oUSCQF6BAltKk4ATb43NxiVAuSEhpktry2nNYo7M2-ILYPg8ew24SiSLFyKPxN__Y8xNywtknzth4njmXfOoYVy1g7LvpFTnk08A7JhS8bjlI1oGUcEDe5XzLmBQA_C05AD6OANN0SH5d5biY4mM4o7mkaktNSHGp1rt9uWxTzD6YjNSHtV_5EtP2jJrgWjTksZGhUHwwS31uoXGmZY3UxpCLLxVDyXROcUMvwg0u3hrqzLqmpyTFWPIxeTObJeP7_XlEfn75_OPyW3f9_evV5cV1Z6UYSseFcwqEscJIJx04xnrXm3kUE8ztxwINIHPcWG5bSQ1GOQGIqldDv1opOCIfd7p3Kd5XzEVvfLa4LCZgrFkL4Ior0Q-soR9eoLexptBe16ihBymk6BsldpRtK8oJZ32X_MakreZMP3mkdx7p5pF-9khPrel0L11XG3R_W_6Y0gDYAbldtY2lf7P_I_sb85efJQ</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Shu, Penghua</creator><creator>Li, Junping</creator><creator>Fei, Yingying</creator><creator>Zhu, Huiqing</creator><creator>Yu, Mengzhu</creator><creator>Liu, Anqi</creator><creator>Niu, Haoying</creator><creator>Zou, Simin</creator><creator>Wei, Xialan</creator><creator>Ju, Zhiyu</creator><creator>Xu, Zhihong</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3793-6198</orcidid><orcidid>https://orcid.org/0000-0001-6018-8429</orcidid></search><sort><creationdate>20200301</creationdate><title>Isolation, structure elucidation, tyrosinase inhibitory, and antioxidant evaluation of the constituents from Angelica dahurica roots</title><author>Shu, Penghua ; Li, Junping ; Fei, Yingying ; Zhu, Huiqing ; Yu, Mengzhu ; Liu, Anqi ; Niu, Haoying ; Zou, Simin ; Wei, Xialan ; Ju, Zhiyu ; Xu, Zhihong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-12dd932ac2a4d4d3d005d5af7283f2932ea3e0d1ac1c28396a9d23ee95965bb93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Angelica - chemistry</topic><topic>Angelica dahurica</topic><topic>Antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>Antioxidants - therapeutic use</topic><topic>Ascorbic acid</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Complementary & Alternative Medicine</topic><topic>Coumarin</topic><topic>Coumarins - chemistry</topic><topic>Kojic acid</topic><topic>Medicinal Chemistry</topic><topic>Monophenol Monooxygenase - metabolism</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Organic chemicals</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Phenolic compounds</topic><topic>Plant Roots - chemistry</topic><topic>Plant Sciences</topic><topic>Roots</topic><topic>Vitamin C</topic><topic>X-ray diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shu, Penghua</creatorcontrib><creatorcontrib>Li, Junping</creatorcontrib><creatorcontrib>Fei, Yingying</creatorcontrib><creatorcontrib>Zhu, Huiqing</creatorcontrib><creatorcontrib>Yu, Mengzhu</creatorcontrib><creatorcontrib>Liu, Anqi</creatorcontrib><creatorcontrib>Niu, Haoying</creatorcontrib><creatorcontrib>Zou, Simin</creatorcontrib><creatorcontrib>Wei, Xialan</creatorcontrib><creatorcontrib>Ju, Zhiyu</creatorcontrib><creatorcontrib>Xu, Zhihong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shu, Penghua</au><au>Li, Junping</au><au>Fei, Yingying</au><au>Zhu, Huiqing</au><au>Yu, Mengzhu</au><au>Liu, Anqi</au><au>Niu, Haoying</au><au>Zou, Simin</au><au>Wei, Xialan</au><au>Ju, Zhiyu</au><au>Xu, Zhihong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isolation, structure elucidation, tyrosinase inhibitory, and antioxidant evaluation of the constituents from Angelica dahurica roots</atitle><jtitle>Journal of natural medicines</jtitle><stitle>J Nat Med</stitle><addtitle>J Nat Med</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>74</volume><issue>2</issue><spage>456</spage><epage>462</epage><pages>456-462</pages><issn>1340-3443</issn><eissn>1861-0293</eissn><abstract>Two undescribed phenolic compounds, angelicols A (
1
) and B (
2
) and one undescribed coumarin rhamnoside, angelicoside A (
3
), together with 17 known compounds (
4
–
20
) were isolated from the roots of
Angelica dahurica
. Their structures were characterized by physical data analyses such as NMR, HRESIMS, and X-ray diffraction. Compounds
2
,
3
,
5
,
6
and L-ascorbic acid (positive control) exhibited obvious DPPH radical scavenging activities with IC
50
values of 0.36 mM, 0.43 mM, 0.39 mM, 0.44 mM, 0.25 mM, respectively. At a concentration of 25 μM, all compounds showed weaker tyrosinase inhibition activities (%inhibition < 5%) than kojic acid (26.00 ± 0.67%, IC
50
= 44.29 ± 0.06 μM).</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>31773388</pmid><doi>10.1007/s11418-019-01375-8</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-3793-6198</orcidid><orcidid>https://orcid.org/0000-0001-6018-8429</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1340-3443 |
| ispartof | Journal of natural medicines, 2020-03, Vol.74 (2), p.456-462 |
| issn | 1340-3443 1861-0293 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2319192560 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Angelica - chemistry Angelica dahurica Antioxidants Antioxidants - pharmacology Antioxidants - therapeutic use Ascorbic acid Biomedical and Life Sciences Biomedicine Complementary & Alternative Medicine Coumarin Coumarins - chemistry Kojic acid Medicinal Chemistry Monophenol Monooxygenase - metabolism NMR Nuclear magnetic resonance Organic chemicals Pharmacology/Toxicology Pharmacy Phenolic compounds Plant Roots - chemistry Plant Sciences Roots Vitamin C X-ray diffraction |
| title | Isolation, structure elucidation, tyrosinase inhibitory, and antioxidant evaluation of the constituents from Angelica dahurica roots |
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