Protective role of Nrf2 against ischemia reperfusion injury and cardiac allograft vasculopathy

Ischemia‐reperfusion injury (IRI) and cardiac allograft vasculopathy (CAV) remain unsolved complications post–heart transplant (Tx). The antioxidant transcription factor Nuclear factor erythroid 2‐related factor 2 (Nrf2) has been suggested to inhibit reactive oxygen species‐mediated NF‐κB activation...

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Veröffentlicht in:	American journal of transplantation 2020-05, Vol.20 (5), p.1262-1271
Hauptverfasser:	Fukunaga, Naoto, Kawajiri, Hiroyuki, Badiwala, Mitesh V., Butany, Jagdish, Li, Ren‐ke, Billia, Filio, Rao, Vivek
Format:	Artikel
Sprache:	eng
Schlagworte:	Allografts Animal models Animals Antioxidants Apoptosis basic (laboratory) research/science Cardiovascular disease Caspase heart (allograft) function/dysfunction heart disease: immune/inflammatory Heart transplantation heart transplantation/cardiology Heart transplants Inflammation Ischemia Mice Mice, Inbred C57BL NF-E2-Related Factor 2 - genetics NF-kappa B Reactive oxygen species Reperfusion Reperfusion Injury - prevention & control Rodents Sulforaphane Superoxide dismutase Vascular diseases
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