Ligustilide promotes apoptosis of cancer-associated fibroblasts via the TLR4 pathways

The goal of this research was to study the selective pro-apoptotic effect of ligustilide on prostate-cancer-associated fibroblast in the tumor microenvironment and the related molecular mechanisms. The effects of ligustilide on cancer-associated fibroblasts (CAFs) and normal fibroblasts (NFs) isolat...

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Veröffentlicht in:	Food and chemical toxicology 2020-01, Vol.135, p.110991-110991, Article 110991
Hauptverfasser:	Ma, Jing, Mei, Jie, Lu, Jia, Wang, Yuanyuan, Hu, Minghua, Ma, Fangli, Long, Hanan, Qin, Zhihai, Tao, Ning
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Butyrolactone - analogs & derivatives 4-Butyrolactone - pharmacology Animals Apoptosis Apoptosis - drug effects Cancer-Associated Fibroblasts - drug effects Cell cycle Cell Cycle - drug effects Cell Proliferation - drug effects Fibroblast Heterografts Humans Ligustilide Male Mice Mice, Inbred C57BL Prostatic Neoplasms - pathology Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Tumor Microenvironment
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