A dual GLP-1 and Gcg receptor agonist rescues spatial memory and synaptic plasticity in APP/PS1 transgenic mice

Alzheimer's disease (AD) is a neurodegenerative disease that severely affects the health and lifespan of the elderly worldwide. Recently, the correlation between AD and type 2 diabetes mellitus (T2DM) has received intensive attention, and a promising new anti-AD strategy is the use of anti-diab...

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Veröffentlicht in:	Hormones and behavior 2020-02, Vol.118, p.104640-104640, Article 104640
Hauptverfasser:	Wang, Zhao-Jun, Han, Yu-Fei, Zhao, Fang, Yang, Guang-Zhao, Yuan, Li, Cai, Hong-Yan, Yang, Jun-Ting, Holscher, Christian, Qi, Jin-Shun, Wu, Mei-Na
Format:	Artikel
Sprache:	eng
Schlagworte:	(D-Ser2) oxyntomodulin APP/PS1 transgenic mice GLP-l receptor Glucagon receptor Learning and memory Long-term potentiation PI3K/AKT/GSK3β
Online-Zugang:	Volltext
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