Frustration and Emotional Regulation in Nonsyndromic Craniosynostosis: A Functional Magnetic Resonance Imaging Study
Nonsyndromic craniosynostosis may manifest with complex behavioral, attentional, and emotional sequelae. The authors characterized higher level brain connectivity in adolescent nonsyndromic craniosynostosis patients in response to emotional frustration. Surgically corrected patients older than 9 yea...
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| Veröffentlicht in: | Plastic and reconstructive surgery (1963) 2019-12, Vol.144 (6), p.1371-1383 |
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| creator | Wu, Robin T. Yang, Jenny F. Zucconi, William Lacadie, Cheryl Swallow, Matthew S. Sun, Alexander H. Eilbott, Jeffrey Mayes, Linda C. Steinbacher, Derek M. Pelphrey, Kevin Persing, John A. |
| description | Nonsyndromic craniosynostosis may manifest with complex behavioral, attentional, and emotional sequelae. The authors characterized higher level brain connectivity in adolescent nonsyndromic craniosynostosis patients in response to emotional frustration.
Surgically corrected patients older than 9 years with nonsyndromic craniosynostosis were age/sex/handedness matched to controls. Patients participated in a "go/no-go" task, structured as win/lose/recovery paradigms. BioImage Suite was used to analyze whole-brain intrinsic connectivity between tasks with cluster-corrected group-level t maps. A value of p < 0.05 was significant.
Seven unilateral coronal (average age, 12.2 years), six metopic (average age, 11.5 years), and controls were included. Unilateral coronal had worse emotional regulation scores on the Behavior Rating Inventory of Executive Function survey (p = 0.065) and performed poorly on the go/no-go task (p < 0.001). Metopic had four regions of interest, with the majority having decreased activity compared with controls, and few differences between tasks. Unilateral coronal patients had 11 regions of interest; the majority decreased during the win and lose conditions, but all increased during the recovery condition. Metopic patients had decreased blood oxygenation level- dependent signal in the posterior cingulate (p = 0.017) and middle temporal gyrus (p = 0.042). Unilateral coronal had decreased signal in the posterior cingulate (p = 0.023), middle temporal gyrus (p = 0.027), and thalamus (p = 0.033), but increased signal in the cuneus (p = 0.009) and cerebellum (p = 0.009). Right unilateral coronal, but not metopic/controls, had increased right brain activity in the caudate (p = 0.030), thalamus (p = 0.011), temporal lobe (p = 0.012), and cerebellum (p = 0.029).
Unilateral coronal patients may have emotional dysregulation in response to frustration, whereas metopic patients may have attenuated emotional reactions. Evidence of right unilateral coronal brain laterality suggests that the area of suture fusion may contribute to the mechanism of dysfunction.
Risk, II. |
| doi_str_mv | 10.1097/PRS.0000000000005850 |
| format | Article |
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Surgically corrected patients older than 9 years with nonsyndromic craniosynostosis were age/sex/handedness matched to controls. Patients participated in a "go/no-go" task, structured as win/lose/recovery paradigms. BioImage Suite was used to analyze whole-brain intrinsic connectivity between tasks with cluster-corrected group-level t maps. A value of p < 0.05 was significant.
Seven unilateral coronal (average age, 12.2 years), six metopic (average age, 11.5 years), and controls were included. Unilateral coronal had worse emotional regulation scores on the Behavior Rating Inventory of Executive Function survey (p = 0.065) and performed poorly on the go/no-go task (p < 0.001). Metopic had four regions of interest, with the majority having decreased activity compared with controls, and few differences between tasks. Unilateral coronal patients had 11 regions of interest; the majority decreased during the win and lose conditions, but all increased during the recovery condition. Metopic patients had decreased blood oxygenation level- dependent signal in the posterior cingulate (p = 0.017) and middle temporal gyrus (p = 0.042). Unilateral coronal had decreased signal in the posterior cingulate (p = 0.023), middle temporal gyrus (p = 0.027), and thalamus (p = 0.033), but increased signal in the cuneus (p = 0.009) and cerebellum (p = 0.009). Right unilateral coronal, but not metopic/controls, had increased right brain activity in the caudate (p = 0.030), thalamus (p = 0.011), temporal lobe (p = 0.012), and cerebellum (p = 0.029).
Unilateral coronal patients may have emotional dysregulation in response to frustration, whereas metopic patients may have attenuated emotional reactions. Evidence of right unilateral coronal brain laterality suggests that the area of suture fusion may contribute to the mechanism of dysfunction.
Risk, II.</description><identifier>ISSN: 0032-1052</identifier><identifier>EISSN: 1529-4242</identifier><identifier>DOI: 10.1097/PRS.0000000000005850</identifier><identifier>PMID: 31764655</identifier><language>eng</language><publisher>United States: by the American Society of Plastic Surgeons</publisher><subject>Case-Control Studies ; Child ; Craniosynostoses - blood ; Craniosynostoses - psychology ; Emotional Regulation - physiology ; Female ; Frustration ; Humans ; Magnetic Resonance Imaging ; Male ; Oxygen - blood ; Prospective Studies ; Psychological Tests</subject><ispartof>Plastic and reconstructive surgery (1963), 2019-12, Vol.144 (6), p.1371-1383</ispartof><rights>by the American Society of Plastic Surgeons</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3520-cad5d393e62566f1e4d98bef18da8c504c9aa3fd6888b815804ee60a347722d93</citedby><cites>FETCH-LOGICAL-c3520-cad5d393e62566f1e4d98bef18da8c504c9aa3fd6888b815804ee60a347722d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31764655$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Robin T.</creatorcontrib><creatorcontrib>Yang, Jenny F.</creatorcontrib><creatorcontrib>Zucconi, William</creatorcontrib><creatorcontrib>Lacadie, Cheryl</creatorcontrib><creatorcontrib>Swallow, Matthew S.</creatorcontrib><creatorcontrib>Sun, Alexander H.</creatorcontrib><creatorcontrib>Eilbott, Jeffrey</creatorcontrib><creatorcontrib>Mayes, Linda C.</creatorcontrib><creatorcontrib>Steinbacher, Derek M.</creatorcontrib><creatorcontrib>Pelphrey, Kevin</creatorcontrib><creatorcontrib>Persing, John A.</creatorcontrib><title>Frustration and Emotional Regulation in Nonsyndromic Craniosynostosis: A Functional Magnetic Resonance Imaging Study</title><title>Plastic and reconstructive surgery (1963)</title><addtitle>Plast Reconstr Surg</addtitle><description>Nonsyndromic craniosynostosis may manifest with complex behavioral, attentional, and emotional sequelae. The authors characterized higher level brain connectivity in adolescent nonsyndromic craniosynostosis patients in response to emotional frustration.
Surgically corrected patients older than 9 years with nonsyndromic craniosynostosis were age/sex/handedness matched to controls. Patients participated in a "go/no-go" task, structured as win/lose/recovery paradigms. BioImage Suite was used to analyze whole-brain intrinsic connectivity between tasks with cluster-corrected group-level t maps. A value of p < 0.05 was significant.
Seven unilateral coronal (average age, 12.2 years), six metopic (average age, 11.5 years), and controls were included. Unilateral coronal had worse emotional regulation scores on the Behavior Rating Inventory of Executive Function survey (p = 0.065) and performed poorly on the go/no-go task (p < 0.001). Metopic had four regions of interest, with the majority having decreased activity compared with controls, and few differences between tasks. Unilateral coronal patients had 11 regions of interest; the majority decreased during the win and lose conditions, but all increased during the recovery condition. Metopic patients had decreased blood oxygenation level- dependent signal in the posterior cingulate (p = 0.017) and middle temporal gyrus (p = 0.042). Unilateral coronal had decreased signal in the posterior cingulate (p = 0.023), middle temporal gyrus (p = 0.027), and thalamus (p = 0.033), but increased signal in the cuneus (p = 0.009) and cerebellum (p = 0.009). Right unilateral coronal, but not metopic/controls, had increased right brain activity in the caudate (p = 0.030), thalamus (p = 0.011), temporal lobe (p = 0.012), and cerebellum (p = 0.029).
Unilateral coronal patients may have emotional dysregulation in response to frustration, whereas metopic patients may have attenuated emotional reactions. Evidence of right unilateral coronal brain laterality suggests that the area of suture fusion may contribute to the mechanism of dysfunction.
Risk, II.</description><subject>Case-Control Studies</subject><subject>Child</subject><subject>Craniosynostoses - blood</subject><subject>Craniosynostoses - psychology</subject><subject>Emotional Regulation - physiology</subject><subject>Female</subject><subject>Frustration</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Oxygen - blood</subject><subject>Prospective Studies</subject><subject>Psychological Tests</subject><issn>0032-1052</issn><issn>1529-4242</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkFtrFDEYhoModtv6D0Ry6c20OU_iXVm6tlC1bPV6yCbfbEdnkppkKPvvTbvrAQMh3-F938CD0FtKzigx7fnt-u6M_HOkluQFWlDJTCOYYC_RghDOGkokO0LHOX8nhLZcydfoiNNWCSXlApVVmnNJtgwxYBs8vpziU21HvIbtPO4XQ8CfY8i74FOcBoeXyYYh1j7mEvOQP-ALvJqDOzg_2W2AUnVryHUQHODryW6HsMV3Zfa7U_Sqt2OGN4f3BH1bXX5dXjU3Xz5eLy9uGsclI42zXnpuOCgmleopCG_0BnqqvdVOEuGMtbz3Smu90VRqIgAUsVy0LWPe8BP0fp_7kOLPGXLppiE7GEcbIM65Y5WDUUoYXqViL3Up5pyg7x7SMNm06yjpnnh3lXf3P-9qe3f4Yd5M4P-YfgP-m_sYxwIp_xjnR0jdPdix3D_nKclFwwg1lNWuqZcT_gtcnYyE</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Wu, Robin T.</creator><creator>Yang, Jenny F.</creator><creator>Zucconi, William</creator><creator>Lacadie, Cheryl</creator><creator>Swallow, Matthew S.</creator><creator>Sun, Alexander H.</creator><creator>Eilbott, Jeffrey</creator><creator>Mayes, Linda C.</creator><creator>Steinbacher, Derek M.</creator><creator>Pelphrey, Kevin</creator><creator>Persing, John A.</creator><general>by the American Society of Plastic Surgeons</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20191201</creationdate><title>Frustration and Emotional Regulation in Nonsyndromic Craniosynostosis: A Functional Magnetic Resonance Imaging Study</title><author>Wu, Robin T. ; Yang, Jenny F. ; Zucconi, William ; Lacadie, Cheryl ; Swallow, Matthew S. ; Sun, Alexander H. ; Eilbott, Jeffrey ; Mayes, Linda C. ; Steinbacher, Derek M. ; Pelphrey, Kevin ; Persing, John A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3520-cad5d393e62566f1e4d98bef18da8c504c9aa3fd6888b815804ee60a347722d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Case-Control Studies</topic><topic>Child</topic><topic>Craniosynostoses - blood</topic><topic>Craniosynostoses - psychology</topic><topic>Emotional Regulation - physiology</topic><topic>Female</topic><topic>Frustration</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Oxygen - blood</topic><topic>Prospective Studies</topic><topic>Psychological Tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Robin T.</creatorcontrib><creatorcontrib>Yang, Jenny F.</creatorcontrib><creatorcontrib>Zucconi, William</creatorcontrib><creatorcontrib>Lacadie, Cheryl</creatorcontrib><creatorcontrib>Swallow, Matthew S.</creatorcontrib><creatorcontrib>Sun, Alexander H.</creatorcontrib><creatorcontrib>Eilbott, Jeffrey</creatorcontrib><creatorcontrib>Mayes, Linda C.</creatorcontrib><creatorcontrib>Steinbacher, Derek M.</creatorcontrib><creatorcontrib>Pelphrey, Kevin</creatorcontrib><creatorcontrib>Persing, John A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Plastic and reconstructive surgery (1963)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Robin T.</au><au>Yang, Jenny F.</au><au>Zucconi, William</au><au>Lacadie, Cheryl</au><au>Swallow, Matthew S.</au><au>Sun, Alexander H.</au><au>Eilbott, Jeffrey</au><au>Mayes, Linda C.</au><au>Steinbacher, Derek M.</au><au>Pelphrey, Kevin</au><au>Persing, John A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Frustration and Emotional Regulation in Nonsyndromic Craniosynostosis: A Functional Magnetic Resonance Imaging Study</atitle><jtitle>Plastic and reconstructive surgery (1963)</jtitle><addtitle>Plast Reconstr Surg</addtitle><date>2019-12-01</date><risdate>2019</risdate><volume>144</volume><issue>6</issue><spage>1371</spage><epage>1383</epage><pages>1371-1383</pages><issn>0032-1052</issn><eissn>1529-4242</eissn><abstract>Nonsyndromic craniosynostosis may manifest with complex behavioral, attentional, and emotional sequelae. The authors characterized higher level brain connectivity in adolescent nonsyndromic craniosynostosis patients in response to emotional frustration.
Surgically corrected patients older than 9 years with nonsyndromic craniosynostosis were age/sex/handedness matched to controls. Patients participated in a "go/no-go" task, structured as win/lose/recovery paradigms. BioImage Suite was used to analyze whole-brain intrinsic connectivity between tasks with cluster-corrected group-level t maps. A value of p < 0.05 was significant.
Seven unilateral coronal (average age, 12.2 years), six metopic (average age, 11.5 years), and controls were included. Unilateral coronal had worse emotional regulation scores on the Behavior Rating Inventory of Executive Function survey (p = 0.065) and performed poorly on the go/no-go task (p < 0.001). Metopic had four regions of interest, with the majority having decreased activity compared with controls, and few differences between tasks. Unilateral coronal patients had 11 regions of interest; the majority decreased during the win and lose conditions, but all increased during the recovery condition. Metopic patients had decreased blood oxygenation level- dependent signal in the posterior cingulate (p = 0.017) and middle temporal gyrus (p = 0.042). Unilateral coronal had decreased signal in the posterior cingulate (p = 0.023), middle temporal gyrus (p = 0.027), and thalamus (p = 0.033), but increased signal in the cuneus (p = 0.009) and cerebellum (p = 0.009). Right unilateral coronal, but not metopic/controls, had increased right brain activity in the caudate (p = 0.030), thalamus (p = 0.011), temporal lobe (p = 0.012), and cerebellum (p = 0.029).
Unilateral coronal patients may have emotional dysregulation in response to frustration, whereas metopic patients may have attenuated emotional reactions. Evidence of right unilateral coronal brain laterality suggests that the area of suture fusion may contribute to the mechanism of dysfunction.
Risk, II.</abstract><cop>United States</cop><pub>by the American Society of Plastic Surgeons</pub><pmid>31764655</pmid><doi>10.1097/PRS.0000000000005850</doi><tpages>13</tpages></addata></record> |
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| subjects | Case-Control Studies Child Craniosynostoses - blood Craniosynostoses - psychology Emotional Regulation - physiology Female Frustration Humans Magnetic Resonance Imaging Male Oxygen - blood Prospective Studies Psychological Tests |
| title | Frustration and Emotional Regulation in Nonsyndromic Craniosynostosis: A Functional Magnetic Resonance Imaging Study |
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