Local hepcidin increased intracellular iron overload via the degradation of ferroportin in the kidney

Hepcidin is a key regulator of iron homeostasis. Some studies showed that exogenous hepcidin decreased the expression of divalent metal transporter (DMT1) rather than ferroportin(FPN1) to regulate renal iron metabolism. This study explored the effects of hepcidin synthesized by the kidney and its me...

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Veröffentlicht in:	Biochemical and biophysical research communications 2020-02, Vol.522 (2), p.322-327
Hauptverfasser:	Pan, Sai, Qian, Zhong-Ming, Cui, Shaoyuan, Zhao, Delong, Lan, Weiren, Wang, Xu, Chen, Xiangmei
Format:	Artikel
Sprache:	eng
Schlagworte:	Ferroportin Hepcidin Iron overload Kidney
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