Solo Smart Fluorogenic Probe for Potential Cancer Diagnosis and Tracking in Vivo Tumorous Lymphatic Systems via Distinct Emission Signals
A versatile twisted-intramolecular-charge-transfer (TICT)-based near-infrared (NIR) fluorescent probe (L) has been judiciously designed and synthesized that could be utilized for potential cancer diagnosis and to track lymph node(s) in mice through distinct emission signals. Essentially, the probe r...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2020-01, Vol.92 (1), p.1541-1548 |
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| container_title | Analytical chemistry (Washington) |
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| creator | Samanta, Soham Huang, Meina Lin, Fangrui Das, Pintu Chen, Bingling Yan, Wei Chen, Jia-Jie Ji, Kunmei Liu, Liwei Qu, Junle Yang, Zhigang |
| description | A versatile twisted-intramolecular-charge-transfer (TICT)-based near-infrared (NIR) fluorescent probe (L) has been judiciously designed and synthesized that could be utilized for potential cancer diagnosis and to track lymph node(s) in mice through distinct emission signals. Essentially, the probe rendered the capability to preferentially recognize the cancer cells over the noncancer cells by polarity-guided lipid droplet specific differential bioimaging (in green emission channel) studies. The probe also exhibited selective turn-on fluorescence response toward HSA/BSA in physiological media (aqueous PBS buffer; pH 7.4) at far-red/NIR regions, because of the 1:1 chelation between the probe and HSA/BSA. Therefore, the fluorescent probe was then maneuvered to track the draining lymphatic system and sentinel lymph node in tumor mice model by fluorescence imaging (NIR/deep-red channel), wherein the accumulated albumin protein in the draining tumor lymphatic system facilitated the in situ formation of the fluorescent albumin–L complex. |
| doi_str_mv | 10.1021/acs.analchem.9b04834 |
| format | Article |
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Essentially, the probe rendered the capability to preferentially recognize the cancer cells over the noncancer cells by polarity-guided lipid droplet specific differential bioimaging (in green emission channel) studies. The probe also exhibited selective turn-on fluorescence response toward HSA/BSA in physiological media (aqueous PBS buffer; pH 7.4) at far-red/NIR regions, because of the 1:1 chelation between the probe and HSA/BSA. Therefore, the fluorescent probe was then maneuvered to track the draining lymphatic system and sentinel lymph node in tumor mice model by fluorescence imaging (NIR/deep-red channel), wherein the accumulated albumin protein in the draining tumor lymphatic system facilitated the in situ formation of the fluorescent albumin–L complex.</description><identifier>ISSN: 0003-2700</identifier><identifier>EISSN: 1520-6882</identifier><identifier>DOI: 10.1021/acs.analchem.9b04834</identifier><identifier>PMID: 31760749</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Albumin ; Albumins ; Analytical chemistry ; Animals ; Breast Neoplasms - diagnostic imaging ; Cancer ; Cell Line, Tumor ; Charge transfer ; Chelation ; Chemistry ; Diagnosis ; Disease Models, Animal ; Drainage channels ; Emission analysis ; Female ; Fluorescence ; Fluorescent Dyes - chemical synthesis ; Fluorescent Dyes - chemistry ; Fluorescent indicators ; Lipids ; Lymph nodes ; Lymph Nodes - diagnostic imaging ; Lymphatic system ; Lymphatic System - diagnostic imaging ; Medical diagnosis ; Medical imaging ; Mice ; Molecular Structure ; Optical Imaging ; Polarity ; Tracking ; Tumors</subject><ispartof>Analytical chemistry (Washington), 2020-01, Vol.92 (1), p.1541-1548</ispartof><rights>Copyright American Chemical Society Jan 7, 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a376t-f01998c01384dcd392566e68e68e7c017540de510956e6f6c43c36f6f0833993</citedby><cites>FETCH-LOGICAL-a376t-f01998c01384dcd392566e68e68e7c017540de510956e6f6c43c36f6f0833993</cites><orcidid>0000-0002-6530-4617 ; 0000-0002-5333-611X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.analchem.9b04834$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.analchem.9b04834$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31760749$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Samanta, Soham</creatorcontrib><creatorcontrib>Huang, Meina</creatorcontrib><creatorcontrib>Lin, Fangrui</creatorcontrib><creatorcontrib>Das, Pintu</creatorcontrib><creatorcontrib>Chen, Bingling</creatorcontrib><creatorcontrib>Yan, Wei</creatorcontrib><creatorcontrib>Chen, Jia-Jie</creatorcontrib><creatorcontrib>Ji, Kunmei</creatorcontrib><creatorcontrib>Liu, Liwei</creatorcontrib><creatorcontrib>Qu, Junle</creatorcontrib><creatorcontrib>Yang, Zhigang</creatorcontrib><title>Solo Smart Fluorogenic Probe for Potential Cancer Diagnosis and Tracking in Vivo Tumorous Lymphatic Systems via Distinct Emission Signals</title><title>Analytical chemistry (Washington)</title><addtitle>Anal. Chem</addtitle><description>A versatile twisted-intramolecular-charge-transfer (TICT)-based near-infrared (NIR) fluorescent probe (L) has been judiciously designed and synthesized that could be utilized for potential cancer diagnosis and to track lymph node(s) in mice through distinct emission signals. Essentially, the probe rendered the capability to preferentially recognize the cancer cells over the noncancer cells by polarity-guided lipid droplet specific differential bioimaging (in green emission channel) studies. The probe also exhibited selective turn-on fluorescence response toward HSA/BSA in physiological media (aqueous PBS buffer; pH 7.4) at far-red/NIR regions, because of the 1:1 chelation between the probe and HSA/BSA. 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Chem</addtitle><date>2020-01-07</date><risdate>2020</risdate><volume>92</volume><issue>1</issue><spage>1541</spage><epage>1548</epage><pages>1541-1548</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><abstract>A versatile twisted-intramolecular-charge-transfer (TICT)-based near-infrared (NIR) fluorescent probe (L) has been judiciously designed and synthesized that could be utilized for potential cancer diagnosis and to track lymph node(s) in mice through distinct emission signals. Essentially, the probe rendered the capability to preferentially recognize the cancer cells over the noncancer cells by polarity-guided lipid droplet specific differential bioimaging (in green emission channel) studies. The probe also exhibited selective turn-on fluorescence response toward HSA/BSA in physiological media (aqueous PBS buffer; pH 7.4) at far-red/NIR regions, because of the 1:1 chelation between the probe and HSA/BSA. Therefore, the fluorescent probe was then maneuvered to track the draining lymphatic system and sentinel lymph node in tumor mice model by fluorescence imaging (NIR/deep-red channel), wherein the accumulated albumin protein in the draining tumor lymphatic system facilitated the in situ formation of the fluorescent albumin–L complex.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>31760749</pmid><doi>10.1021/acs.analchem.9b04834</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6530-4617</orcidid><orcidid>https://orcid.org/0000-0002-5333-611X</orcidid></addata></record> |
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| subjects | Albumin Albumins Analytical chemistry Animals Breast Neoplasms - diagnostic imaging Cancer Cell Line, Tumor Charge transfer Chelation Chemistry Diagnosis Disease Models, Animal Drainage channels Emission analysis Female Fluorescence Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Fluorescent indicators Lipids Lymph nodes Lymph Nodes - diagnostic imaging Lymphatic system Lymphatic System - diagnostic imaging Medical diagnosis Medical imaging Mice Molecular Structure Optical Imaging Polarity Tracking Tumors |
| title | Solo Smart Fluorogenic Probe for Potential Cancer Diagnosis and Tracking in Vivo Tumorous Lymphatic Systems via Distinct Emission Signals |
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