Excess weight mediates changes in HDL pool that reduce cholesterol efflux capacity and increase antioxidant activity

Excess weight mediates changes in HDL pool that reduce cholesterol efflux capacity and increase antioxidant activity

Obesity-related decline in high-density lipoprotein (HDL) functions such as cholesterol efflux capacity (CEC) has supported the notion that this lipoprotein dysfunction may contribute for atherogenesis among obese patients. We investigated if potentially other HDL protective actions may be affected...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2020-02, Vol.30 (2), p.254-264
Hauptverfasser: de Lima-Junior, Jose Carlos, Virginio, Vitor W.M., Moura, Filipe A., Bertolami, Adriana, Bertolami, Marcelo, Coelho-Filho, Otavio R., Zanotti, Ilaria, Nadruz, Wilson, de Faria, Eliana Cotta, de Carvalho, Luiz Sergio F., Sposito, Andrei C.
Format: Artikel
Sprache:eng
Schlagworte:
Atherosclerosis
Cholesterol efflux
HDL
HDL metabolism
Obesity
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 264
container_issue 2
container_start_page 254
container_title Nutrition, metabolism, and cardiovascular diseases
container_volume 30
creator de Lima-Junior, Jose Carlos
Virginio, Vitor W.M.
Moura, Filipe A.
Bertolami, Adriana
Bertolami, Marcelo
Coelho-Filho, Otavio R.
Zanotti, Ilaria
Nadruz, Wilson
de Faria, Eliana Cotta
de Carvalho, Luiz Sergio F.
Sposito, Andrei C.
description Obesity-related decline in high-density lipoprotein (HDL) functions such as cholesterol efflux capacity (CEC) has supported the notion that this lipoprotein dysfunction may contribute for atherogenesis among obese patients. We investigated if potentially other HDL protective actions may be affected with weight gain and these changes may occur even before the obesity range in a cross-sectional analysis. Lipid profile, body mass index (BMI), biochemical measurements, and carotid intima-media thickness (cIMT) were obtained in this cross-sectional study with 899 asymptomatic individuals. Lipoproteins were separated by ultracentrifugation and HDL physical-chemical characterization, CEC, antioxidant activity, anti-inflammatory activity, HDL-mediated platelet aggregation inhibition were measured in a randomly-selected subgroup (n = 101). Individuals with increased HDL-C had an attenuated increase in cIMT with elevation of BMI (interaction effect β = −0.054; CI 95% −0.0815, −0.0301). CEC, HDL-C, HDL size and HDL-antioxidant activity were negatively associated with cIMT. BMI was inversely correlated with HDL-mediated inhibition of platelet aggregation (Spearman's rho −0.157, p 
doi_str_mv 10.1016/j.numecd.2019.09.017
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2317598880</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0939475319303564</els_id><sourcerecordid>2317598880</sourcerecordid><originalsourceid>FETCH-LOGICAL-c408t-2be4948aa520980e661ba0a14420af17f0bfe1fa9b053cba0c178293a35560183</originalsourceid><addsrcrecordid>eNp9kEFr3DAQhUVpaTZp_0EpOubi7ciy19KlEJI0CSz00p7FWB5ntXjtrSQnm3_fWTbNsTDw0Mx7GukT4ouCpQK1-rZdjvOOfLcsQdklcKnmnVio2kKhm9K-Fwuw2hZVU-szcZ7SFkA3oKuP4kwrbjbGLkS-PXhKST5TeNxkuaMuYKYk_QbHR9YwyvubtdxP0yDzBrOM1M2eeD4NlDJF7lPfD_NBetyjD_lF4thxzkfCRHzIYTqEjlWiz-GJHZ_Ehx6HRJ9f9UL8_nH76_q-WP-8e7i-Whe-ApOLsqXKVgaxLsEaoNVKtQioqqoE7FXTQ9uT6tG2UGvPI68aU1qNuq5XoIy-EJene_dx-jPzc90uJE_DgCNNc3LlkYM1xgBbq5PVxymlSL3bx7DD-OIUuCNvt3Un3u7I2wGXajj29XXD3DK7t9A_wGz4fjIQ__MpUHTJBxo9c47ks-um8P8NfwFrp5Si</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2317598880</pqid></control><display><type>article</type><title>Excess weight mediates changes in HDL pool that reduce cholesterol efflux capacity and increase antioxidant activity</title><source>Elsevier ScienceDirect Journals Complete</source><creator>de Lima-Junior, Jose Carlos ; Virginio, Vitor W.M. ; Moura, Filipe A. ; Bertolami, Adriana ; Bertolami, Marcelo ; Coelho-Filho, Otavio R. ; Zanotti, Ilaria ; Nadruz, Wilson ; de Faria, Eliana Cotta ; de Carvalho, Luiz Sergio F. ; Sposito, Andrei C.</creator><creatorcontrib>de Lima-Junior, Jose Carlos ; Virginio, Vitor W.M. ; Moura, Filipe A. ; Bertolami, Adriana ; Bertolami, Marcelo ; Coelho-Filho, Otavio R. ; Zanotti, Ilaria ; Nadruz, Wilson ; de Faria, Eliana Cotta ; de Carvalho, Luiz Sergio F. ; Sposito, Andrei C.</creatorcontrib><description>Obesity-related decline in high-density lipoprotein (HDL) functions such as cholesterol efflux capacity (CEC) has supported the notion that this lipoprotein dysfunction may contribute for atherogenesis among obese patients. We investigated if potentially other HDL protective actions may be affected with weight gain and these changes may occur even before the obesity range in a cross-sectional analysis. Lipid profile, body mass index (BMI), biochemical measurements, and carotid intima-media thickness (cIMT) were obtained in this cross-sectional study with 899 asymptomatic individuals. Lipoproteins were separated by ultracentrifugation and HDL physical-chemical characterization, CEC, antioxidant activity, anti-inflammatory activity, HDL-mediated platelet aggregation inhibition were measured in a randomly-selected subgroup (n = 101). Individuals with increased HDL-C had an attenuated increase in cIMT with elevation of BMI (interaction effect β = −0.054; CI 95% −0.0815, −0.0301). CEC, HDL-C, HDL size and HDL-antioxidant activity were negatively associated with cIMT. BMI was inversely correlated with HDL-mediated inhibition of platelet aggregation (Spearman's rho −0.157, p &lt; 0.03) and CEC (Spearman's rho −0.32, p &lt; 0.001), but surprisingly it was directly correlated with the antioxidant activity (Spearman's rho 0.194, p = 0.052). Thus, even in non-obese, non-diabetic individuals, increased BMI is associated with a wide change in protective functions of HDL, reducing CEC and increasing antioxidant activity. In these subjects, decreased HDL concentration, size or function are related to increased atherosclerotic burden. Our findings demonstrate that in non-obese, non-diabetic individuals, the increasing values of BMI are associated with impaired protective functions of HDL and concomitant increase in atherosclerotic burden. •Multiple and complex relationship exists between HDL functions and excess weight.•BMI is inversely associated with HDL-mediated inhibition of platelet aggregation and CEC, but directly associated with the antioxidant activity.•Decreased HDL concentration, size or function are related to increased atherosclerotic burden and increased BMI.</description><identifier>ISSN: 0939-4753</identifier><identifier>EISSN: 1590-3729</identifier><identifier>DOI: 10.1016/j.numecd.2019.09.017</identifier><identifier>PMID: 31753789</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Atherosclerosis ; Cholesterol efflux ; HDL ; HDL metabolism ; Obesity</subject><ispartof>Nutrition, metabolism, and cardiovascular diseases, 2020-02, Vol.30 (2), p.254-264</ispartof><rights>2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University</rights><rights>Copyright © 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-2be4948aa520980e661ba0a14420af17f0bfe1fa9b053cba0c178293a35560183</citedby><cites>FETCH-LOGICAL-c408t-2be4948aa520980e661ba0a14420af17f0bfe1fa9b053cba0c178293a35560183</cites><orcidid>0000-0001-8017-1675 ; 0000-0003-2701-6021 ; 0000-0001-7127-2052 ; 0000-0001-9430-4475</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.numecd.2019.09.017$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31753789$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Lima-Junior, Jose Carlos</creatorcontrib><creatorcontrib>Virginio, Vitor W.M.</creatorcontrib><creatorcontrib>Moura, Filipe A.</creatorcontrib><creatorcontrib>Bertolami, Adriana</creatorcontrib><creatorcontrib>Bertolami, Marcelo</creatorcontrib><creatorcontrib>Coelho-Filho, Otavio R.</creatorcontrib><creatorcontrib>Zanotti, Ilaria</creatorcontrib><creatorcontrib>Nadruz, Wilson</creatorcontrib><creatorcontrib>de Faria, Eliana Cotta</creatorcontrib><creatorcontrib>de Carvalho, Luiz Sergio F.</creatorcontrib><creatorcontrib>Sposito, Andrei C.</creatorcontrib><title>Excess weight mediates changes in HDL pool that reduce cholesterol efflux capacity and increase antioxidant activity</title><title>Nutrition, metabolism, and cardiovascular diseases</title><addtitle>Nutr Metab Cardiovasc Dis</addtitle><description>Obesity-related decline in high-density lipoprotein (HDL) functions such as cholesterol efflux capacity (CEC) has supported the notion that this lipoprotein dysfunction may contribute for atherogenesis among obese patients. We investigated if potentially other HDL protective actions may be affected with weight gain and these changes may occur even before the obesity range in a cross-sectional analysis. Lipid profile, body mass index (BMI), biochemical measurements, and carotid intima-media thickness (cIMT) were obtained in this cross-sectional study with 899 asymptomatic individuals. Lipoproteins were separated by ultracentrifugation and HDL physical-chemical characterization, CEC, antioxidant activity, anti-inflammatory activity, HDL-mediated platelet aggregation inhibition were measured in a randomly-selected subgroup (n = 101). Individuals with increased HDL-C had an attenuated increase in cIMT with elevation of BMI (interaction effect β = −0.054; CI 95% −0.0815, −0.0301). CEC, HDL-C, HDL size and HDL-antioxidant activity were negatively associated with cIMT. BMI was inversely correlated with HDL-mediated inhibition of platelet aggregation (Spearman's rho −0.157, p &lt; 0.03) and CEC (Spearman's rho −0.32, p &lt; 0.001), but surprisingly it was directly correlated with the antioxidant activity (Spearman's rho 0.194, p = 0.052). Thus, even in non-obese, non-diabetic individuals, increased BMI is associated with a wide change in protective functions of HDL, reducing CEC and increasing antioxidant activity. In these subjects, decreased HDL concentration, size or function are related to increased atherosclerotic burden. Our findings demonstrate that in non-obese, non-diabetic individuals, the increasing values of BMI are associated with impaired protective functions of HDL and concomitant increase in atherosclerotic burden. •Multiple and complex relationship exists between HDL functions and excess weight.•BMI is inversely associated with HDL-mediated inhibition of platelet aggregation and CEC, but directly associated with the antioxidant activity.•Decreased HDL concentration, size or function are related to increased atherosclerotic burden and increased BMI.</description><subject>Atherosclerosis</subject><subject>Cholesterol efflux</subject><subject>HDL</subject><subject>HDL metabolism</subject><subject>Obesity</subject><issn>0939-4753</issn><issn>1590-3729</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kEFr3DAQhUVpaTZp_0EpOubi7ciy19KlEJI0CSz00p7FWB5ntXjtrSQnm3_fWTbNsTDw0Mx7GukT4ouCpQK1-rZdjvOOfLcsQdklcKnmnVio2kKhm9K-Fwuw2hZVU-szcZ7SFkA3oKuP4kwrbjbGLkS-PXhKST5TeNxkuaMuYKYk_QbHR9YwyvubtdxP0yDzBrOM1M2eeD4NlDJF7lPfD_NBetyjD_lF4thxzkfCRHzIYTqEjlWiz-GJHZ_Ehx6HRJ9f9UL8_nH76_q-WP-8e7i-Whe-ApOLsqXKVgaxLsEaoNVKtQioqqoE7FXTQ9uT6tG2UGvPI68aU1qNuq5XoIy-EJene_dx-jPzc90uJE_DgCNNc3LlkYM1xgBbq5PVxymlSL3bx7DD-OIUuCNvt3Un3u7I2wGXajj29XXD3DK7t9A_wGz4fjIQ__MpUHTJBxo9c47ks-um8P8NfwFrp5Si</recordid><startdate>20200210</startdate><enddate>20200210</enddate><creator>de Lima-Junior, Jose Carlos</creator><creator>Virginio, Vitor W.M.</creator><creator>Moura, Filipe A.</creator><creator>Bertolami, Adriana</creator><creator>Bertolami, Marcelo</creator><creator>Coelho-Filho, Otavio R.</creator><creator>Zanotti, Ilaria</creator><creator>Nadruz, Wilson</creator><creator>de Faria, Eliana Cotta</creator><creator>de Carvalho, Luiz Sergio F.</creator><creator>Sposito, Andrei C.</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8017-1675</orcidid><orcidid>https://orcid.org/0000-0003-2701-6021</orcidid><orcidid>https://orcid.org/0000-0001-7127-2052</orcidid><orcidid>https://orcid.org/0000-0001-9430-4475</orcidid></search><sort><creationdate>20200210</creationdate><title>Excess weight mediates changes in HDL pool that reduce cholesterol efflux capacity and increase antioxidant activity</title><author>de Lima-Junior, Jose Carlos ; Virginio, Vitor W.M. ; Moura, Filipe A. ; Bertolami, Adriana ; Bertolami, Marcelo ; Coelho-Filho, Otavio R. ; Zanotti, Ilaria ; Nadruz, Wilson ; de Faria, Eliana Cotta ; de Carvalho, Luiz Sergio F. ; Sposito, Andrei C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-2be4948aa520980e661ba0a14420af17f0bfe1fa9b053cba0c178293a35560183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Atherosclerosis</topic><topic>Cholesterol efflux</topic><topic>HDL</topic><topic>HDL metabolism</topic><topic>Obesity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Lima-Junior, Jose Carlos</creatorcontrib><creatorcontrib>Virginio, Vitor W.M.</creatorcontrib><creatorcontrib>Moura, Filipe A.</creatorcontrib><creatorcontrib>Bertolami, Adriana</creatorcontrib><creatorcontrib>Bertolami, Marcelo</creatorcontrib><creatorcontrib>Coelho-Filho, Otavio R.</creatorcontrib><creatorcontrib>Zanotti, Ilaria</creatorcontrib><creatorcontrib>Nadruz, Wilson</creatorcontrib><creatorcontrib>de Faria, Eliana Cotta</creatorcontrib><creatorcontrib>de Carvalho, Luiz Sergio F.</creatorcontrib><creatorcontrib>Sposito, Andrei C.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Lima-Junior, Jose Carlos</au><au>Virginio, Vitor W.M.</au><au>Moura, Filipe A.</au><au>Bertolami, Adriana</au><au>Bertolami, Marcelo</au><au>Coelho-Filho, Otavio R.</au><au>Zanotti, Ilaria</au><au>Nadruz, Wilson</au><au>de Faria, Eliana Cotta</au><au>de Carvalho, Luiz Sergio F.</au><au>Sposito, Andrei C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Excess weight mediates changes in HDL pool that reduce cholesterol efflux capacity and increase antioxidant activity</atitle><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle><addtitle>Nutr Metab Cardiovasc Dis</addtitle><date>2020-02-10</date><risdate>2020</risdate><volume>30</volume><issue>2</issue><spage>254</spage><epage>264</epage><pages>254-264</pages><issn>0939-4753</issn><eissn>1590-3729</eissn><abstract>Obesity-related decline in high-density lipoprotein (HDL) functions such as cholesterol efflux capacity (CEC) has supported the notion that this lipoprotein dysfunction may contribute for atherogenesis among obese patients. We investigated if potentially other HDL protective actions may be affected with weight gain and these changes may occur even before the obesity range in a cross-sectional analysis. Lipid profile, body mass index (BMI), biochemical measurements, and carotid intima-media thickness (cIMT) were obtained in this cross-sectional study with 899 asymptomatic individuals. Lipoproteins were separated by ultracentrifugation and HDL physical-chemical characterization, CEC, antioxidant activity, anti-inflammatory activity, HDL-mediated platelet aggregation inhibition were measured in a randomly-selected subgroup (n = 101). Individuals with increased HDL-C had an attenuated increase in cIMT with elevation of BMI (interaction effect β = −0.054; CI 95% −0.0815, −0.0301). CEC, HDL-C, HDL size and HDL-antioxidant activity were negatively associated with cIMT. BMI was inversely correlated with HDL-mediated inhibition of platelet aggregation (Spearman's rho −0.157, p &lt; 0.03) and CEC (Spearman's rho −0.32, p &lt; 0.001), but surprisingly it was directly correlated with the antioxidant activity (Spearman's rho 0.194, p = 0.052). Thus, even in non-obese, non-diabetic individuals, increased BMI is associated with a wide change in protective functions of HDL, reducing CEC and increasing antioxidant activity. In these subjects, decreased HDL concentration, size or function are related to increased atherosclerotic burden. Our findings demonstrate that in non-obese, non-diabetic individuals, the increasing values of BMI are associated with impaired protective functions of HDL and concomitant increase in atherosclerotic burden. •Multiple and complex relationship exists between HDL functions and excess weight.•BMI is inversely associated with HDL-mediated inhibition of platelet aggregation and CEC, but directly associated with the antioxidant activity.•Decreased HDL concentration, size or function are related to increased atherosclerotic burden and increased BMI.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>31753789</pmid><doi>10.1016/j.numecd.2019.09.017</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-8017-1675</orcidid><orcidid>https://orcid.org/0000-0003-2701-6021</orcidid><orcidid>https://orcid.org/0000-0001-7127-2052</orcidid><orcidid>https://orcid.org/0000-0001-9430-4475</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0939-4753
ispartof Nutrition, metabolism, and cardiovascular diseases, 2020-02, Vol.30 (2), p.254-264
issn 0939-4753
1590-3729
language eng
recordid cdi_proquest_miscellaneous_2317598880
source Elsevier ScienceDirect Journals Complete
subjects Atherosclerosis
Cholesterol efflux
HDL
HDL metabolism
Obesity
title Excess weight mediates changes in HDL pool that reduce cholesterol efflux capacity and increase antioxidant activity
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T07%3A10%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Excess%20weight%20mediates%20changes%20in%20HDL%20pool%20that%20reduce%20cholesterol%20efflux%20capacity%20and%20increase%20antioxidant%20activity&rft.jtitle=Nutrition,%20metabolism,%20and%20cardiovascular%20diseases&rft.au=de%20Lima-Junior,%20Jose%20Carlos&rft.date=2020-02-10&rft.volume=30&rft.issue=2&rft.spage=254&rft.epage=264&rft.pages=254-264&rft.issn=0939-4753&rft.eissn=1590-3729&rft_id=info:doi/10.1016/j.numecd.2019.09.017&rft_dat=%3Cproquest_cross%3E2317598880%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2317598880&rft_id=info:pmid/31753789&rft_els_id=S0939475319303564&rfr_iscdi=true