Enhanced antifungal activity of fluconazole conjugated with Cu-Ag-ZnO nanocomposite

Cu-Ag-ZnO nanocomposite (NC) has been successfully synthesized by mechanical alloying the Cu, Zn and Ag powder mixture under Ar atmosphere within 4 h of milling. The nanocomposite is then conjugated with the antifungal drug fluconazole by adding 5 wt% powdered drug to the NC and mechanical alloying...

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Veröffentlicht in:	Materials Science & Engineering C 2020-01, Vol.106, p.110160-110160, Article 110160
Hauptverfasser:	Ghosh, Moupiya, Mandal, Samir, Roy, Anindita, Chakrabarty, Subhendu, Chakrabarti, Gopal, Pradhan, Swapan Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	Alloy powders Antibiotics Antifungal activity Antifungal Agents - chemistry Antifungal Agents - pharmacology Candida - drug effects Cell Line, Tumor Cell Survival - drug effects Conjugates Conjugation Copper Copper - chemistry Crystallites Crystals Cytotoxicity Disease control Epidemics Fluconazole Fluconazole - chemistry Fluconazole - pharmacology Fungi Fungicides Humans Materials science Mechanical alloying Microbial Sensitivity Tests Minimum inhibitory concentration Minimum inhibitory concentration (MIC) Nanocomposite Nanocomposites Nanocomposites - chemistry Particle Size Powder Side effects Silver Silver - chemistry Zinc Zinc oxide Zinc Oxide - chemistry
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