A novel NR3C2 polymorphism and the increased thyroid-stimulating hormone concentration are associated with venlafaxine treatment outcome in Chinese Han MDD patients
Objective: We aimed to study the association among venlafaxine antidepressive outcome, NR3C2 gene polymorphisms and the change of two neuroendocrine hormones during treatment. Methods: 195 Chinese Han major depressive disorder (MDD) patients were recruited and received a 6-week venlafaxine treatment...
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| Veröffentlicht in: | Psychiatry research 2020-02, Vol.284, p.112690-112690, Article 112690 |
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| creator | Yuan, Fan Yuan, Ruixue Ren, Decheng Bi, Yan Niu, Weibo Guo, Zhenming Wu, Xi Xu, Fei Sun, Qianqian Ma, Gaini Yang, Fengping Zhu, Yuhao Yu, Tao Li, Xingwang He, Lin Shi, Lei He, Guang |
| description | Objective: We aimed to study the association among venlafaxine antidepressive outcome, NR3C2 gene polymorphisms and the change of two neuroendocrine hormones during treatment. Methods: 195 Chinese Han major depressive disorder (MDD) patients were recruited and received a 6-week venlafaxine treatment in this study. Adrenocorticotropic hormone (ACTH), thyroid-stimulating hormone (TSH) levels were measured at the beginning and at the end of treatment. Six single-nucleotide polymorphisms (SNPs) (NR3C2: rs1512325, rs1512342, rs2070951; NR3C1: rs6191, rs6196, rs10482614) were selected for high-throughput SNP genotyping. Allele and genotype frequencies of them were compared between remission and non-remission groups. Results: We found that genotype frequency of the rs1512325 located in the NR3C2 gene was significantly different between remission and non-remission groups respectively (p |
| doi_str_mv | 10.1016/j.psychres.2019.112690 |
| format | Article |
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Methods: 195 Chinese Han major depressive disorder (MDD) patients were recruited and received a 6-week venlafaxine treatment in this study. Adrenocorticotropic hormone (ACTH), thyroid-stimulating hormone (TSH) levels were measured at the beginning and at the end of treatment. Six single-nucleotide polymorphisms (SNPs) (NR3C2: rs1512325, rs1512342, rs2070951; NR3C1: rs6191, rs6196, rs10482614) were selected for high-throughput SNP genotyping. Allele and genotype frequencies of them were compared between remission and non-remission groups. Results: We found that genotype frequency of the rs1512325 located in the NR3C2 gene was significantly different between remission and non-remission groups respectively (p < 0.05). Meanwhile, the frequency of the rs1512325 C-allele was significantly lower (p < 0.05) in remission group. The TSH concentration significantly increased after venlafaxine treatment in remission group (p < 0.05). Conclusion: The rs1512325 in NR3C2 gene and TSH concentration may be related to venlafaxine treatment outcome in Chinese Han MDD patients.</description><identifier>ISSN: 0165-1781</identifier><identifier>EISSN: 1872-7123</identifier><identifier>DOI: 10.1016/j.psychres.2019.112690</identifier><identifier>PMID: 31757642</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Antidepressants ; NR3C2 ; Thyroid-stimulating hormone</subject><ispartof>Psychiatry research, 2020-02, Vol.284, p.112690-112690, Article 112690</ispartof><rights>2019</rights><rights>Copyright © 2019. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-21623ab909d4f09998155390f7e110321bb0764fa2b79b758232eb74263b25b93</citedby><cites>FETCH-LOGICAL-c368t-21623ab909d4f09998155390f7e110321bb0764fa2b79b758232eb74263b25b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S016517811932133X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31757642$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yuan, Fan</creatorcontrib><creatorcontrib>Yuan, Ruixue</creatorcontrib><creatorcontrib>Ren, Decheng</creatorcontrib><creatorcontrib>Bi, Yan</creatorcontrib><creatorcontrib>Niu, Weibo</creatorcontrib><creatorcontrib>Guo, Zhenming</creatorcontrib><creatorcontrib>Wu, Xi</creatorcontrib><creatorcontrib>Xu, Fei</creatorcontrib><creatorcontrib>Sun, Qianqian</creatorcontrib><creatorcontrib>Ma, Gaini</creatorcontrib><creatorcontrib>Yang, Fengping</creatorcontrib><creatorcontrib>Zhu, Yuhao</creatorcontrib><creatorcontrib>Yu, Tao</creatorcontrib><creatorcontrib>Li, Xingwang</creatorcontrib><creatorcontrib>He, Lin</creatorcontrib><creatorcontrib>Shi, Lei</creatorcontrib><creatorcontrib>He, Guang</creatorcontrib><title>A novel NR3C2 polymorphism and the increased thyroid-stimulating hormone concentration are associated with venlafaxine treatment outcome in Chinese Han MDD patients</title><title>Psychiatry research</title><addtitle>Psychiatry Res</addtitle><description>Objective: We aimed to study the association among venlafaxine antidepressive outcome, NR3C2 gene polymorphisms and the change of two neuroendocrine hormones during treatment. Methods: 195 Chinese Han major depressive disorder (MDD) patients were recruited and received a 6-week venlafaxine treatment in this study. Adrenocorticotropic hormone (ACTH), thyroid-stimulating hormone (TSH) levels were measured at the beginning and at the end of treatment. Six single-nucleotide polymorphisms (SNPs) (NR3C2: rs1512325, rs1512342, rs2070951; NR3C1: rs6191, rs6196, rs10482614) were selected for high-throughput SNP genotyping. Allele and genotype frequencies of them were compared between remission and non-remission groups. Results: We found that genotype frequency of the rs1512325 located in the NR3C2 gene was significantly different between remission and non-remission groups respectively (p < 0.05). Meanwhile, the frequency of the rs1512325 C-allele was significantly lower (p < 0.05) in remission group. The TSH concentration significantly increased after venlafaxine treatment in remission group (p < 0.05). Conclusion: The rs1512325 in NR3C2 gene and TSH concentration may be related to venlafaxine treatment outcome in Chinese Han MDD patients.</description><subject>Antidepressants</subject><subject>NR3C2</subject><subject>Thyroid-stimulating hormone</subject><issn>0165-1781</issn><issn>1872-7123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFkc1u1DAUhS0EotPCK1RessnUP5M43lFNgSIVkBCsLdu5IR4ldrCdgXkfHhRH07JlZdn-zjm69yB0TcmWEtrcHLZzOtkhQtoyQuWWUtZI8gxtaCtYJSjjz9GmgHVFRUsv0GVKB0IIo1K-RBecilo0O7ZBf26xD0cY8eevfM_wHMbTFOI8uDRh7TucB8DO2wg6wXo7xeC6KmU3LaPOzv_AQ4hT8IBt8BZ8juU1eKwjYJ1SsE7nIvzl8oCP4Efd69-u0Lk45qnwOCzZhmlNwfuhfCXA99rjT3d3eC5eBUmv0ItejwleP55X6Pv7d9_299XDlw8f97cPleVNmytGG8a1kUR2u55IKVta11ySXgClhDNqDClT95oZIY2oW8YZGLFjDTesNpJfoTdn3zmGnwukrCaXLIyj9hCWpNi6N0mYIAVtzqiNIaUIvZqjm3Q8KUrU2pA6qKeG1NqQOjdUhNePGYuZoPsne6qkAG_PAJRJjw6iSrZswULnItisuuD-l_EX6F2n3g</recordid><startdate>202002</startdate><enddate>202002</enddate><creator>Yuan, Fan</creator><creator>Yuan, Ruixue</creator><creator>Ren, Decheng</creator><creator>Bi, Yan</creator><creator>Niu, Weibo</creator><creator>Guo, Zhenming</creator><creator>Wu, Xi</creator><creator>Xu, Fei</creator><creator>Sun, Qianqian</creator><creator>Ma, Gaini</creator><creator>Yang, Fengping</creator><creator>Zhu, Yuhao</creator><creator>Yu, Tao</creator><creator>Li, Xingwang</creator><creator>He, Lin</creator><creator>Shi, Lei</creator><creator>He, Guang</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202002</creationdate><title>A novel NR3C2 polymorphism and the increased thyroid-stimulating hormone concentration are associated with venlafaxine treatment outcome in Chinese Han MDD patients</title><author>Yuan, Fan ; Yuan, Ruixue ; Ren, Decheng ; Bi, Yan ; Niu, Weibo ; Guo, Zhenming ; Wu, Xi ; Xu, Fei ; Sun, Qianqian ; Ma, Gaini ; Yang, Fengping ; Zhu, Yuhao ; Yu, Tao ; Li, Xingwang ; He, Lin ; Shi, Lei ; He, Guang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-21623ab909d4f09998155390f7e110321bb0764fa2b79b758232eb74263b25b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antidepressants</topic><topic>NR3C2</topic><topic>Thyroid-stimulating hormone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yuan, Fan</creatorcontrib><creatorcontrib>Yuan, Ruixue</creatorcontrib><creatorcontrib>Ren, Decheng</creatorcontrib><creatorcontrib>Bi, Yan</creatorcontrib><creatorcontrib>Niu, Weibo</creatorcontrib><creatorcontrib>Guo, Zhenming</creatorcontrib><creatorcontrib>Wu, Xi</creatorcontrib><creatorcontrib>Xu, Fei</creatorcontrib><creatorcontrib>Sun, Qianqian</creatorcontrib><creatorcontrib>Ma, Gaini</creatorcontrib><creatorcontrib>Yang, Fengping</creatorcontrib><creatorcontrib>Zhu, Yuhao</creatorcontrib><creatorcontrib>Yu, Tao</creatorcontrib><creatorcontrib>Li, Xingwang</creatorcontrib><creatorcontrib>He, Lin</creatorcontrib><creatorcontrib>Shi, Lei</creatorcontrib><creatorcontrib>He, Guang</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yuan, Fan</au><au>Yuan, Ruixue</au><au>Ren, Decheng</au><au>Bi, Yan</au><au>Niu, Weibo</au><au>Guo, Zhenming</au><au>Wu, Xi</au><au>Xu, Fei</au><au>Sun, Qianqian</au><au>Ma, Gaini</au><au>Yang, Fengping</au><au>Zhu, Yuhao</au><au>Yu, Tao</au><au>Li, Xingwang</au><au>He, Lin</au><au>Shi, Lei</au><au>He, Guang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A novel NR3C2 polymorphism and the increased thyroid-stimulating hormone concentration are associated with venlafaxine treatment outcome in Chinese Han MDD patients</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>2020-02</date><risdate>2020</risdate><volume>284</volume><spage>112690</spage><epage>112690</epage><pages>112690-112690</pages><artnum>112690</artnum><issn>0165-1781</issn><eissn>1872-7123</eissn><abstract>Objective: We aimed to study the association among venlafaxine antidepressive outcome, NR3C2 gene polymorphisms and the change of two neuroendocrine hormones during treatment. Methods: 195 Chinese Han major depressive disorder (MDD) patients were recruited and received a 6-week venlafaxine treatment in this study. Adrenocorticotropic hormone (ACTH), thyroid-stimulating hormone (TSH) levels were measured at the beginning and at the end of treatment. Six single-nucleotide polymorphisms (SNPs) (NR3C2: rs1512325, rs1512342, rs2070951; NR3C1: rs6191, rs6196, rs10482614) were selected for high-throughput SNP genotyping. Allele and genotype frequencies of them were compared between remission and non-remission groups. Results: We found that genotype frequency of the rs1512325 located in the NR3C2 gene was significantly different between remission and non-remission groups respectively (p < 0.05). Meanwhile, the frequency of the rs1512325 C-allele was significantly lower (p < 0.05) in remission group. The TSH concentration significantly increased after venlafaxine treatment in remission group (p < 0.05). Conclusion: The rs1512325 in NR3C2 gene and TSH concentration may be related to venlafaxine treatment outcome in Chinese Han MDD patients.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>31757642</pmid><doi>10.1016/j.psychres.2019.112690</doi><tpages>1</tpages></addata></record> |
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| title | A novel NR3C2 polymorphism and the increased thyroid-stimulating hormone concentration are associated with venlafaxine treatment outcome in Chinese Han MDD patients |
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