The Addition of Polar Organic Solvent Vapors During the Analysis of Proteins by DESI-MS

Exposure of electrospray droplets to organic vapors was shown to dramatically reduce alkali-metal adduction on protein ions and shift protein charge states. Since DESI-MS is affected by similar adduct species as ESI-MS and shares similar ionization mechanisms, polar organic vapor additives should li...

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Veröffentlicht in:	Journal of the American Society for Mass Spectrometry 2019-12, Vol.30 (12), p.2571-2575
Hauptverfasser:	Javanshad, Roshan, Maser, Tara L., Honarvar, Elahe, Venter, Andre R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - chemistry Acetone Acetone - chemistry Acetonitrile Acetonitriles - chemistry Additives Alkali metals Analytical Chemistry Animals Bioinformatics Biotechnology Carbonic anhydrase Carbonic Anhydrase II - analysis Cattle Charge distribution Chemistry Chemistry and Materials Science Cytochromes c - analysis Equipment Design Ethyl acetate Horses Ions Mass spectrometry Methanol - chemistry Organic Chemistry Proteins Proteins - analysis Proteomics Serum albumin Serum Albumin, Bovine - analysis Short Communication Solvents Solvents - chemistry Spectrometry, Mass, Electrospray Ionization - instrumentation Spectrometry, Mass, Electrospray Ionization - methods Vapors Volatilization Water - chemistry
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