Clinicopathological profile of gastrointestinal tuberculosis: a multinational ID-IRI study
Data are relatively scarce on gastro-intestinal tuberculosis (GITB). Most studies are old and from single centers, or did not include immunosuppressed patients. Thus, we aimed to determine the clinical, radiological, and laboratory profiles of GITB. We included adults with proven GITB treated betwee...
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| Veröffentlicht in: | European journal of clinical microbiology & infectious diseases 2020-03, Vol.39 (3), p.493-500 |
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| creator | Tanoglu, Alpaslan Erdem, Hakan Friedland, Jon S. Almajid, Fahad M. Batirel, Ayse Kulzhanova, Sholpan Konkayeva, Maiya Smagulova, Zauresh Pehlivanoglu, Filiz de Saram, Sophia Gulsun, Serda Amer, Fatma Balkan, Ilker Inanc Tekin, Recep Cascio, Antonio Dauby, Nicolas Sirmatel, Fatma Tasbakan, Meltem Erdem, Aysegul Wegdan, Ahmed Ashraf Aydin, Ozlem Cesur, Salih Deniz, Secil Senbayrak, Seniha Denk, Affan Duzenli, Tolga Siméon, Soline Oncul, Ahsen Ozseker, Burak Yakar, Tolga Ormeci, Necati |
| description | Data are relatively scarce on gastro-intestinal tuberculosis (GITB). Most studies are old and from single centers, or did not include immunosuppressed patients. Thus, we aimed to determine the clinical, radiological, and laboratory profiles of GITB. We included adults with proven GITB treated between 2000 and 2018. Patients were enrolled from 21 referral centers in 8 countries (Belgium, Egypt, France, Italy, Kazakhstan, Saudi Arabia, UK, and Turkey). One hundred four patients were included. Terminal ileum (
n
= 46, 44.2%), small intestines except terminal ileum (
n
= 36, 34.6%), colon (
n
= 29, 27.8%), stomach (
n
= 6, 5.7%), and perianal (one patient) were the sites of GITB. One-third of all patients were immunosuppressed. Sixteen patients had diabetes, 8 had chronic renal failure, 5 were HIV positive, 4 had liver cirrhosis, and 3 had malignancies. Intestinal biopsy samples were cultured in 75 cases (78.1%) and TB was isolated in 65 patients (86.6%). PCR were performed to 37 (35.6%) biopsy samples and of these, 35 (94.6%) were positive. Ascites samples were cultured in 19 patients and
M. tuberculosis
was isolated in 11 (57.9%). Upper gastrointestinal endoscopy was performed to 40 patients (38.5%) and colonoscopy in 74 (71.1%). Surgical interventions were frequently the source of diagnostic samples (25 laparoscopy/20 laparotomy,
n
= 45, 43.3%). Patients were treated with standard and second-line anti-TB medications. Ultimately, 4 (3.8%) patients died and 2 (1.9%) cases relapsed. There was a high incidence of underlying immunosuppression in GITB patients. A high degree of clinical suspicion is necessary to initiate appropriate and timely diagnostic procedures; many patients are first diagnosed at surgery. |
| doi_str_mv | 10.1007/s10096-019-03749-y |
| format | Article |
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n
= 46, 44.2%), small intestines except terminal ileum (
n
= 36, 34.6%), colon (
n
= 29, 27.8%), stomach (
n
= 6, 5.7%), and perianal (one patient) were the sites of GITB. One-third of all patients were immunosuppressed. Sixteen patients had diabetes, 8 had chronic renal failure, 5 were HIV positive, 4 had liver cirrhosis, and 3 had malignancies. Intestinal biopsy samples were cultured in 75 cases (78.1%) and TB was isolated in 65 patients (86.6%). PCR were performed to 37 (35.6%) biopsy samples and of these, 35 (94.6%) were positive. Ascites samples were cultured in 19 patients and
M. tuberculosis
was isolated in 11 (57.9%). Upper gastrointestinal endoscopy was performed to 40 patients (38.5%) and colonoscopy in 74 (71.1%). Surgical interventions were frequently the source of diagnostic samples (25 laparoscopy/20 laparotomy,
n
= 45, 43.3%). Patients were treated with standard and second-line anti-TB medications. Ultimately, 4 (3.8%) patients died and 2 (1.9%) cases relapsed. There was a high incidence of underlying immunosuppression in GITB patients. A high degree of clinical suspicion is necessary to initiate appropriate and timely diagnostic procedures; many patients are first diagnosed at surgery.</description><identifier>ISSN: 0934-9723</identifier><identifier>EISSN: 1435-4373</identifier><identifier>DOI: 10.1007/s10096-019-03749-y</identifier><identifier>PMID: 31758440</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Ascites ; Biomedical and Life Sciences ; Biomedicine ; Biopsy ; Cirrhosis ; Colon ; Diabetes mellitus ; Diagnostic systems ; Endoscopy ; HIV ; Human immunodeficiency virus ; Ileum ; Immunosuppression ; Internal Medicine ; Intestine ; Laparoscopy ; Liver cirrhosis ; Medical Microbiology ; Original Article ; Patients ; Renal failure ; Surgery ; Tuberculosis</subject><ispartof>European journal of clinical microbiology & infectious diseases, 2020-03, Vol.39 (3), p.493-500</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>European Journal of Clinical Microbiology and Infectious Diseases is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-7a72e4a956a16a6e676f13ae4cf9e9c4e333de0e32040a3a9c4a87fa6a1e2b923</citedby><cites>FETCH-LOGICAL-c441t-7a72e4a956a16a6e676f13ae4cf9e9c4e333de0e32040a3a9c4a87fa6a1e2b923</cites><orcidid>0000-0002-6265-5227</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10096-019-03749-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10096-019-03749-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31758440$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanoglu, Alpaslan</creatorcontrib><creatorcontrib>Erdem, Hakan</creatorcontrib><creatorcontrib>Friedland, Jon S.</creatorcontrib><creatorcontrib>Almajid, Fahad M.</creatorcontrib><creatorcontrib>Batirel, Ayse</creatorcontrib><creatorcontrib>Kulzhanova, Sholpan</creatorcontrib><creatorcontrib>Konkayeva, Maiya</creatorcontrib><creatorcontrib>Smagulova, Zauresh</creatorcontrib><creatorcontrib>Pehlivanoglu, Filiz</creatorcontrib><creatorcontrib>de Saram, Sophia</creatorcontrib><creatorcontrib>Gulsun, Serda</creatorcontrib><creatorcontrib>Amer, Fatma</creatorcontrib><creatorcontrib>Balkan, Ilker Inanc</creatorcontrib><creatorcontrib>Tekin, Recep</creatorcontrib><creatorcontrib>Cascio, Antonio</creatorcontrib><creatorcontrib>Dauby, Nicolas</creatorcontrib><creatorcontrib>Sirmatel, Fatma</creatorcontrib><creatorcontrib>Tasbakan, Meltem</creatorcontrib><creatorcontrib>Erdem, Aysegul</creatorcontrib><creatorcontrib>Wegdan, Ahmed Ashraf</creatorcontrib><creatorcontrib>Aydin, Ozlem</creatorcontrib><creatorcontrib>Cesur, Salih</creatorcontrib><creatorcontrib>Deniz, Secil</creatorcontrib><creatorcontrib>Senbayrak, Seniha</creatorcontrib><creatorcontrib>Denk, Affan</creatorcontrib><creatorcontrib>Duzenli, Tolga</creatorcontrib><creatorcontrib>Siméon, Soline</creatorcontrib><creatorcontrib>Oncul, Ahsen</creatorcontrib><creatorcontrib>Ozseker, Burak</creatorcontrib><creatorcontrib>Yakar, Tolga</creatorcontrib><creatorcontrib>Ormeci, Necati</creatorcontrib><title>Clinicopathological profile of gastrointestinal tuberculosis: a multinational ID-IRI study</title><title>European journal of clinical microbiology & infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>Data are relatively scarce on gastro-intestinal tuberculosis (GITB). Most studies are old and from single centers, or did not include immunosuppressed patients. Thus, we aimed to determine the clinical, radiological, and laboratory profiles of GITB. We included adults with proven GITB treated between 2000 and 2018. Patients were enrolled from 21 referral centers in 8 countries (Belgium, Egypt, France, Italy, Kazakhstan, Saudi Arabia, UK, and Turkey). One hundred four patients were included. Terminal ileum (
n
= 46, 44.2%), small intestines except terminal ileum (
n
= 36, 34.6%), colon (
n
= 29, 27.8%), stomach (
n
= 6, 5.7%), and perianal (one patient) were the sites of GITB. One-third of all patients were immunosuppressed. Sixteen patients had diabetes, 8 had chronic renal failure, 5 were HIV positive, 4 had liver cirrhosis, and 3 had malignancies. Intestinal biopsy samples were cultured in 75 cases (78.1%) and TB was isolated in 65 patients (86.6%). PCR were performed to 37 (35.6%) biopsy samples and of these, 35 (94.6%) were positive. Ascites samples were cultured in 19 patients and
M. tuberculosis
was isolated in 11 (57.9%). Upper gastrointestinal endoscopy was performed to 40 patients (38.5%) and colonoscopy in 74 (71.1%). Surgical interventions were frequently the source of diagnostic samples (25 laparoscopy/20 laparotomy,
n
= 45, 43.3%). Patients were treated with standard and second-line anti-TB medications. Ultimately, 4 (3.8%) patients died and 2 (1.9%) cases relapsed. There was a high incidence of underlying immunosuppression in GITB patients. A high degree of clinical suspicion is necessary to initiate appropriate and timely diagnostic procedures; many patients are first diagnosed at surgery.</description><subject>Ascites</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biopsy</subject><subject>Cirrhosis</subject><subject>Colon</subject><subject>Diabetes mellitus</subject><subject>Diagnostic systems</subject><subject>Endoscopy</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Ileum</subject><subject>Immunosuppression</subject><subject>Internal Medicine</subject><subject>Intestine</subject><subject>Laparoscopy</subject><subject>Liver cirrhosis</subject><subject>Medical Microbiology</subject><subject>Original Article</subject><subject>Patients</subject><subject>Renal failure</subject><subject>Surgery</subject><subject>Tuberculosis</subject><issn>0934-9723</issn><issn>1435-4373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kEtPAyEUhYnR2Pr4Ay7MJG7coDDQYXBn6muSJiZGN24Ind6pNMxQgVn030sfauLCDSSc79x7OAidUXJFCRHXIZ2ywIRKTJjgEq_20JByNsKcCbaPhkQyjqXI2QAdhbAgyVQKcYgGjIpRyTkZovexNZ2p3VLHD2fd3NTaZkvvGmMhc0021yF6Z7oIIZouabGfgq9764IJN5nO2t6uhWjcWq3ucPVSZSH2s9UJOmi0DXC6u4_R28P96_gJT54fq_HtBNec04iFFjlwLUeFpoUuoBBFQ5kGXjcSZM2BMTYDAiwnnGim05MuRaMTDvlU5uwYXW7nptiffcqpWhNqsFZ34Pqg8s1vpeSjhF78QReu9yn4mipyWpZU8ETlW6r2LgQPjVp602q_UpSodfNq27xKzatN82qVTOe70f20hdmP5bvqBLAtEJLUzcH_7v5n7BfJNo_r</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Tanoglu, Alpaslan</creator><creator>Erdem, Hakan</creator><creator>Friedland, Jon S.</creator><creator>Almajid, Fahad M.</creator><creator>Batirel, Ayse</creator><creator>Kulzhanova, 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study</title><author>Tanoglu, Alpaslan ; Erdem, Hakan ; Friedland, Jon S. ; Almajid, Fahad M. ; Batirel, Ayse ; Kulzhanova, Sholpan ; Konkayeva, Maiya ; Smagulova, Zauresh ; Pehlivanoglu, Filiz ; de Saram, Sophia ; Gulsun, Serda ; Amer, Fatma ; Balkan, Ilker Inanc ; Tekin, Recep ; Cascio, Antonio ; Dauby, Nicolas ; Sirmatel, Fatma ; Tasbakan, Meltem ; Erdem, Aysegul ; Wegdan, Ahmed Ashraf ; Aydin, Ozlem ; Cesur, Salih ; Deniz, Secil ; Senbayrak, Seniha ; Denk, Affan ; Duzenli, Tolga ; Siméon, Soline ; Oncul, Ahsen ; Ozseker, Burak ; Yakar, Tolga ; Ormeci, Necati</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-7a72e4a956a16a6e676f13ae4cf9e9c4e333de0e32040a3a9c4a87fa6a1e2b923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Ascites</topic><topic>Biomedical and Life 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Antonio</au><au>Dauby, Nicolas</au><au>Sirmatel, Fatma</au><au>Tasbakan, Meltem</au><au>Erdem, Aysegul</au><au>Wegdan, Ahmed Ashraf</au><au>Aydin, Ozlem</au><au>Cesur, Salih</au><au>Deniz, Secil</au><au>Senbayrak, Seniha</au><au>Denk, Affan</au><au>Duzenli, Tolga</au><au>Siméon, Soline</au><au>Oncul, Ahsen</au><au>Ozseker, Burak</au><au>Yakar, Tolga</au><au>Ormeci, Necati</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinicopathological profile of gastrointestinal tuberculosis: a multinational ID-IRI study</atitle><jtitle>European journal of clinical microbiology & infectious diseases</jtitle><stitle>Eur J Clin Microbiol Infect Dis</stitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>39</volume><issue>3</issue><spage>493</spage><epage>500</epage><pages>493-500</pages><issn>0934-9723</issn><eissn>1435-4373</eissn><abstract>Data are relatively scarce on gastro-intestinal tuberculosis (GITB). Most studies are old and from single centers, or did not include immunosuppressed patients. Thus, we aimed to determine the clinical, radiological, and laboratory profiles of GITB. We included adults with proven GITB treated between 2000 and 2018. Patients were enrolled from 21 referral centers in 8 countries (Belgium, Egypt, France, Italy, Kazakhstan, Saudi Arabia, UK, and Turkey). One hundred four patients were included. Terminal ileum (
n
= 46, 44.2%), small intestines except terminal ileum (
n
= 36, 34.6%), colon (
n
= 29, 27.8%), stomach (
n
= 6, 5.7%), and perianal (one patient) were the sites of GITB. One-third of all patients were immunosuppressed. Sixteen patients had diabetes, 8 had chronic renal failure, 5 were HIV positive, 4 had liver cirrhosis, and 3 had malignancies. Intestinal biopsy samples were cultured in 75 cases (78.1%) and TB was isolated in 65 patients (86.6%). PCR were performed to 37 (35.6%) biopsy samples and of these, 35 (94.6%) were positive. Ascites samples were cultured in 19 patients and
M. tuberculosis
was isolated in 11 (57.9%). Upper gastrointestinal endoscopy was performed to 40 patients (38.5%) and colonoscopy in 74 (71.1%). Surgical interventions were frequently the source of diagnostic samples (25 laparoscopy/20 laparotomy,
n
= 45, 43.3%). Patients were treated with standard and second-line anti-TB medications. Ultimately, 4 (3.8%) patients died and 2 (1.9%) cases relapsed. There was a high incidence of underlying immunosuppression in GITB patients. A high degree of clinical suspicion is necessary to initiate appropriate and timely diagnostic procedures; many patients are first diagnosed at surgery.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31758440</pmid><doi>10.1007/s10096-019-03749-y</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6265-5227</orcidid></addata></record> |
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| ispartof | European journal of clinical microbiology & infectious diseases, 2020-03, Vol.39 (3), p.493-500 |
| issn | 0934-9723 1435-4373 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2317589945 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Ascites Biomedical and Life Sciences Biomedicine Biopsy Cirrhosis Colon Diabetes mellitus Diagnostic systems Endoscopy HIV Human immunodeficiency virus Ileum Immunosuppression Internal Medicine Intestine Laparoscopy Liver cirrhosis Medical Microbiology Original Article Patients Renal failure Surgery Tuberculosis |
| title | Clinicopathological profile of gastrointestinal tuberculosis: a multinational ID-IRI study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T15%3A58%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinicopathological%20profile%20of%20gastrointestinal%20tuberculosis:%20a%20multinational%20ID-IRI%20study&rft.jtitle=European%20journal%20of%20clinical%20microbiology%20&%20infectious%20diseases&rft.au=Tanoglu,%20Alpaslan&rft.date=2020-03-01&rft.volume=39&rft.issue=3&rft.spage=493&rft.epage=500&rft.pages=493-500&rft.issn=0934-9723&rft.eissn=1435-4373&rft_id=info:doi/10.1007/s10096-019-03749-y&rft_dat=%3Cproquest_cross%3E2362188174%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2362188174&rft_id=info:pmid/31758440&rfr_iscdi=true |