Sequential depletion of myeloid-derived suppressor cells and tumor cells with a dual-pH-sensitive conjugated micelle system for cancer chemoimmunotherapy

Myeloid-derived suppressor cells(MDSCs)are one of the most important immunosuppressive cells in tumor microenvironment, which also promote the development and progression of tumor cells. Nevertheless, due to the different distribution features of MDSCs and tumor cells, selective elimination of MDSCs...

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Veröffentlicht in:	Journal of controlled release 2020-01, Vol.317, p.43-56
Hauptverfasser:	Wan, Dandan, Yang, Yiliang, Liu, Yiyao, Cun, Xingli, Li, Man, Xu, Shanshan, Zhao, Wei, Xiang, Yangyang, Qiu, Yue, Yu, Qianwen, Tang, Xian, Zhang, Zhirong, He, Qin
Format:	Artikel
Sprache:	eng
Schlagworte:	Dual-pH-sensitivity Immunosuppression Myeloid-derived suppressor cells (MDSCs) RGX-104 Tumor penetration
Online-Zugang:	Volltext
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