Functional glycomics: Application to medical science and hepatology
Glycomics refers to the comprehensive analysis of glycans. Recent progress in glycotechnology enables the determination of a variety of biological functions of glycans. Among different glycosylation patterns, certain types of aberrant glycosylation are linked to cancer and/or inflammation, and thus...
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| Veröffentlicht in: | Hepatology research 2020-02, Vol.50 (2), p.153-164 |
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| creator | Miyoshi, Eiji Kamada, Yoshihiro Suzuki, Tadashi |
| description | Glycomics refers to the comprehensive analysis of glycans. Recent progress in glycotechnology enables the determination of a variety of biological functions of glycans. Among different glycosylation patterns, certain types of aberrant glycosylation are linked to cancer and/or inflammation, and thus have biological importance. Glycotechnology has been applied to many fields of medical science, including hepatology. In particular, dramatic changes in glycosylation are observed in the progression of liver diseases. As the liver produces so many serum glycoproteins, changes in glycosylation of these proteins might provide useful disease biomarkers. Furthermore, many patients with genetic diseases of glycosylation who have liver dysfunction have been found as a result from whole genome sequencing, and various kinds of glycotherapy have been developed, especially in immunotherapy. In this review, we describe our basic knowledge of glycobiology and discuss the application of these data to medical science, especially hepatology. |
| doi_str_mv | 10.1111/hepr.13459 |
| format | Article |
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Recent progress in glycotechnology enables the determination of a variety of biological functions of glycans. Among different glycosylation patterns, certain types of aberrant glycosylation are linked to cancer and/or inflammation, and thus have biological importance. Glycotechnology has been applied to many fields of medical science, including hepatology. In particular, dramatic changes in glycosylation are observed in the progression of liver diseases. As the liver produces so many serum glycoproteins, changes in glycosylation of these proteins might provide useful disease biomarkers. Furthermore, many patients with genetic diseases of glycosylation who have liver dysfunction have been found as a result from whole genome sequencing, and various kinds of glycotherapy have been developed, especially in immunotherapy. 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In this review, we describe our basic knowledge of glycobiology and discuss the application of these data to medical science, especially hepatology.</description><subject>biomarkers</subject><subject>congenital disorders of glycosylation</subject><subject>Genomes</subject><subject>glycomics</subject><subject>Glycoproteins</subject><subject>Glycosylation</subject><subject>Hepatology</subject><subject>Immunotherapy</subject><subject>Liver diseases</subject><subject>Mac‐2 bp glycosylation isomer</subject><subject>N‐glycanase 1</subject><subject>Polysaccharides</subject><subject>Whole genome sequencing</subject><issn>1386-6346</issn><issn>1872-034X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kE9LwzAYh4Mobk4vfgApeBGhM2n-Nd7G2JwgKKLgLWRZOjvSpjYt0m9vaqcHD-aSvOTh9_J7ADhHcIrCuXk3VT1FmFBxAMYo5UkMMXk7DG-csphhwkbgxPsdhIjDhByDEUacQsH4GMyXbamb3JXKRlvbaVfk2t9Gs6qyuVb9R9S4qDCbMNnI69yU2kSq3ERhq2qcddvuFBxlynpztr8n4HW5eJmv4ofHu_v57CHWhHARG0Q1QQIJzFOSrCHMiFJMaIMYFYhkyqCEM024yowQhOgsY9yIjcrgmhpK8QRcDblV7T5a4xtZ5F4ba1VpXOtlghHjaSgGA3r5B925tg4le4piIWBK00BdD5Sunfe1yWRV54WqO4mg7NXKXq38Vhvgi31kuw4-ftEflwFAA_CZW9P9EyVXi6fnIfQLfz2C7A</recordid><startdate>202002</startdate><enddate>202002</enddate><creator>Miyoshi, Eiji</creator><creator>Kamada, Yoshihiro</creator><creator>Suzuki, Tadashi</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>202002</creationdate><title>Functional glycomics: Application to medical science and hepatology</title><author>Miyoshi, Eiji ; Kamada, Yoshihiro ; Suzuki, Tadashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4479-e15c4191937842b00f4aa69ce165914fae1276c47afe9944cff67e9daf0b5e553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>biomarkers</topic><topic>congenital disorders of glycosylation</topic><topic>Genomes</topic><topic>glycomics</topic><topic>Glycoproteins</topic><topic>Glycosylation</topic><topic>Hepatology</topic><topic>Immunotherapy</topic><topic>Liver diseases</topic><topic>Mac‐2 bp glycosylation isomer</topic><topic>N‐glycanase 1</topic><topic>Polysaccharides</topic><topic>Whole genome sequencing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miyoshi, Eiji</creatorcontrib><creatorcontrib>Kamada, Yoshihiro</creatorcontrib><creatorcontrib>Suzuki, Tadashi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Hepatology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyoshi, Eiji</au><au>Kamada, Yoshihiro</au><au>Suzuki, Tadashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional glycomics: Application to medical science and hepatology</atitle><jtitle>Hepatology research</jtitle><addtitle>Hepatol Res</addtitle><date>2020-02</date><risdate>2020</risdate><volume>50</volume><issue>2</issue><spage>153</spage><epage>164</epage><pages>153-164</pages><issn>1386-6346</issn><eissn>1872-034X</eissn><abstract>Glycomics refers to the comprehensive analysis of glycans. 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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | biomarkers congenital disorders of glycosylation Genomes glycomics Glycoproteins Glycosylation Hepatology Immunotherapy Liver diseases Mac‐2 bp glycosylation isomer N‐glycanase 1 Polysaccharides Whole genome sequencing |
| title | Functional glycomics: Application to medical science and hepatology |
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