Shared Genetic Etiology of Obesity-Related Traits and Barrett's Esophagus/Adenocarcinoma: Insights from Genome-Wide Association Studies

Background: Obesity is a major risk factor for esophageal adenocarcinoma (EA) and its precursor Barrett's esophagus (BE). Research suggests that individuals with high genetic risk to obesity have a higher BE/EA risk. To facilitate understanding of biological factors that lead to progression fro...

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Veröffentlicht in:	Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2020-02, Vol.29 (2), p.427-433
Hauptverfasser:	Boehmer, Anne C., Hecker, Julian, Schroeder, Julia, Gharahkhani, Puya, May, Andrea, Gerges, Christian, Anders, Mario, Becker, Jessica, Hess, Timo, Kreuser, Nicole, Thieme, Rene, Noder, Tania, Venerito, Marino, Veits, Lothar, Schmidt, Thomas, Fuchs, Claudia, Izbicki, Jakob R., Hoelscher, Arnulf H., Dietrich, Arne, Moulla, Yusef, Lyros, Orestis, Lang, Hauke, Lorenz, Dietmar, Schumacher, Brigitte, Mayershofer, Rupert, Vashist, Yogesh, Ott, Katja, Vieth, Michael, Meismueller, Josef, Moebus, Susanne, Knapp, Michael, Neuhaus, Horst, Roesch, Thomas, Ell, Christian, Noethen, Markus M., Whiteman, David C., Tomlinson, Ian, Jankowski, Janusz, Fitzgerald, Rebecca C., Palles, Claire, Vaughan, Thomas L., Gockel, Ines, Thrift, Aaron P., Fier, Heide, Schumacher, Johannes
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - pathology Barrett Esophagus - genetics Barrett Esophagus - pathology Body Mass Index Disease Progression Esophageal Neoplasms - genetics Esophageal Neoplasms - pathology Female Genetic Predisposition to Disease Genome-Wide Association Study Humans Life Sciences & Biomedicine Linkage Disequilibrium Male Meta-Analysis as Topic Obesity - genetics Oncology Polymorphism, Single Nucleotide Public, Environmental & Occupational Health Quantitative Trait Loci Risk Assessment Risk Factors Science & Technology Sex Factors Waist-Hip Ratio
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