Circular RNA hsa_circ_0001178 facilitates the invasion and metastasis of colorectal cancer through upregulating ZEB1 via sponging multiple miRNAs
Metastasis is the main cause of increasing cancer morbidity and mortality. However, the underlying mechanism of cancer metastasis remains largely unknown. In the present study, we identified one circular RNA (circRNA) closely related to the metastasis of colorectal cancer (CRC), namely hsa_circ_0001...
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| Veröffentlicht in: | Biological chemistry 2020-04, Vol.401 (4), p.487-496 |
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| creator | Ren, Chunfeng Zhang, Zhenmin Wang, Shunhua Zhu, Weitao Zheng, Peiguo Wang, Wanhai |
| description | Metastasis is the main cause of increasing cancer morbidity and mortality. However, the underlying mechanism of cancer metastasis remains largely unknown. In the present study, we identified one circular RNA (circRNA) closely related to the metastasis of colorectal cancer (CRC), namely hsa_circ_0001178. CRC patients with high hsa_circ_0001178 were more prone to have metastatic clinical features, advanced TNM stage and adverse prognosis. Stable knockdown of hsa_circ_0001178 significantly weakened CRC cell migratory and invasive capabilities
as well as lung and liver metastases
. Mechanistic study revealed that hsa_circ_0001178 acted as a competing endogenous RNA (ceRNA) for miR-382/587/616 to upregulate ZEB1 (a key trigger of epithelial-to-mesenchymal transition), thereby promoting CRC metastatic dissemination. Of note, ZEB1 could also increase hsa_circ_0001178 expression via physically binding to hsa_circ_0001178 promoter region. Collectively, our data uncover the crucial role of hsa_circ_0001178 in CRC metastasis, and targeted therapy based on this positive feedback ceRNA axis may be a promising treatment for metastatic CRC patients. |
| doi_str_mv | 10.1515/hsz-2019-0350 |
| format | Article |
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as well as lung and liver metastases
. Mechanistic study revealed that hsa_circ_0001178 acted as a competing endogenous RNA (ceRNA) for miR-382/587/616 to upregulate ZEB1 (a key trigger of epithelial-to-mesenchymal transition), thereby promoting CRC metastatic dissemination. Of note, ZEB1 could also increase hsa_circ_0001178 expression via physically binding to hsa_circ_0001178 promoter region. Collectively, our data uncover the crucial role of hsa_circ_0001178 in CRC metastasis, and targeted therapy based on this positive feedback ceRNA axis may be a promising treatment for metastatic CRC patients.</description><identifier>ISSN: 1431-6730</identifier><identifier>EISSN: 1437-4315</identifier><identifier>DOI: 10.1515/hsz-2019-0350</identifier><identifier>PMID: 31747371</identifier><language>eng</language><publisher>Germany: De Gruyter</publisher><subject>Cancer ; Cell migration ; Circular RNA ; Colorectal cancer ; Colorectal carcinoma ; competing endogenous RNA ; In vivo methods and tests ; Invasiveness ; Mesenchyme ; Metastases ; Metastasis ; Morbidity ; Patients ; Positive feedback ; Ribonucleic acid ; RNA</subject><ispartof>Biological chemistry, 2020-04, Vol.401 (4), p.487-496</ispartof><rights>2020 Walter de Gruyter GmbH, Berlin/Boston</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c374t-5d62c2883ce9b075bbd5caadcf75edd235f9b6c99ccf442d84b6d34cf172b9f53</citedby><cites>FETCH-LOGICAL-c374t-5d62c2883ce9b075bbd5caadcf75edd235f9b6c99ccf442d84b6d34cf172b9f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.degruyter.com/document/doi/10.1515/hsz-2019-0350/pdf$$EPDF$$P50$$Gwalterdegruyter$$H</linktopdf><linktohtml>$$Uhttps://www.degruyter.com/document/doi/10.1515/hsz-2019-0350/html$$EHTML$$P50$$Gwalterdegruyter$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,66626,68410</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31747371$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ren, Chunfeng</creatorcontrib><creatorcontrib>Zhang, Zhenmin</creatorcontrib><creatorcontrib>Wang, Shunhua</creatorcontrib><creatorcontrib>Zhu, Weitao</creatorcontrib><creatorcontrib>Zheng, Peiguo</creatorcontrib><creatorcontrib>Wang, Wanhai</creatorcontrib><title>Circular RNA hsa_circ_0001178 facilitates the invasion and metastasis of colorectal cancer through upregulating ZEB1 via sponging multiple miRNAs</title><title>Biological chemistry</title><addtitle>Biol Chem</addtitle><description>Metastasis is the main cause of increasing cancer morbidity and mortality. However, the underlying mechanism of cancer metastasis remains largely unknown. In the present study, we identified one circular RNA (circRNA) closely related to the metastasis of colorectal cancer (CRC), namely hsa_circ_0001178. CRC patients with high hsa_circ_0001178 were more prone to have metastatic clinical features, advanced TNM stage and adverse prognosis. Stable knockdown of hsa_circ_0001178 significantly weakened CRC cell migratory and invasive capabilities
as well as lung and liver metastases
. Mechanistic study revealed that hsa_circ_0001178 acted as a competing endogenous RNA (ceRNA) for miR-382/587/616 to upregulate ZEB1 (a key trigger of epithelial-to-mesenchymal transition), thereby promoting CRC metastatic dissemination. Of note, ZEB1 could also increase hsa_circ_0001178 expression via physically binding to hsa_circ_0001178 promoter region. Collectively, our data uncover the crucial role of hsa_circ_0001178 in CRC metastasis, and targeted therapy based on this positive feedback ceRNA axis may be a promising treatment for metastatic CRC patients.</description><subject>Cancer</subject><subject>Cell migration</subject><subject>Circular RNA</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>competing endogenous RNA</subject><subject>In vivo methods and tests</subject><subject>Invasiveness</subject><subject>Mesenchyme</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Morbidity</subject><subject>Patients</subject><subject>Positive feedback</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><issn>1431-6730</issn><issn>1437-4315</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNptkUtrFjEUhoMotlaXbiXgxs1oMkkmM-CmftQLlAqiGzchk8t8KZnJmEul_Rf-YzN-rYKUBHI4PHnPgQeA5xi9xgyzN_t007QIDw0iDD0Ax5gS3lCC2cM_NW46TtAReJLSJUKoR5Q8BkcEc8oJx8fg185FVbyM8MvFKdwnKVRtiIpizHtopXLeZZlNgnlvoFuuZHJhgXLRcDZZpnpdgsFCFXyIRmXpoZKLMrF-iKFMe1jWaKY6I7tlgt_P3mF45SRMa1imrTMXn93qDZxd3SE9BY-s9Mk8u31PwLf3Z193H5vzzx8-7U7PG0U4zQ3TXavavifKDCPibBw1U1JqZTkzWreE2WHs1DAoZSltdU_HThOqLObtOFhGTsCrQ-4aw49iUhazS8p4LxcTShItwR3vEeOooi__Qy9DiUvdrlK83Q7hlWoOlIohpWisWKObZbwWGInNlaiuxOZKbK4q_-I2tYyz0X_pOzkVeHsAfkqfTdRmiuW6Fv-m3xtMEaa05-Q3zrSkuw</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Ren, Chunfeng</creator><creator>Zhang, Zhenmin</creator><creator>Wang, Shunhua</creator><creator>Zhu, Weitao</creator><creator>Zheng, Peiguo</creator><creator>Wang, Wanhai</creator><general>De Gruyter</general><general>Walter de Gruyter GmbH</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20200401</creationdate><title>Circular RNA hsa_circ_0001178 facilitates the invasion and metastasis of colorectal cancer through upregulating ZEB1 via sponging multiple miRNAs</title><author>Ren, Chunfeng ; Zhang, Zhenmin ; Wang, Shunhua ; Zhu, Weitao ; Zheng, Peiguo ; Wang, Wanhai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-5d62c2883ce9b075bbd5caadcf75edd235f9b6c99ccf442d84b6d34cf172b9f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cancer</topic><topic>Cell migration</topic><topic>Circular RNA</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>competing endogenous RNA</topic><topic>In vivo methods and tests</topic><topic>Invasiveness</topic><topic>Mesenchyme</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Morbidity</topic><topic>Patients</topic><topic>Positive feedback</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ren, Chunfeng</creatorcontrib><creatorcontrib>Zhang, Zhenmin</creatorcontrib><creatorcontrib>Wang, Shunhua</creatorcontrib><creatorcontrib>Zhu, Weitao</creatorcontrib><creatorcontrib>Zheng, Peiguo</creatorcontrib><creatorcontrib>Wang, Wanhai</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ren, Chunfeng</au><au>Zhang, Zhenmin</au><au>Wang, Shunhua</au><au>Zhu, Weitao</au><au>Zheng, Peiguo</au><au>Wang, Wanhai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circular RNA hsa_circ_0001178 facilitates the invasion and metastasis of colorectal cancer through upregulating ZEB1 via sponging multiple miRNAs</atitle><jtitle>Biological chemistry</jtitle><addtitle>Biol Chem</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>401</volume><issue>4</issue><spage>487</spage><epage>496</epage><pages>487-496</pages><issn>1431-6730</issn><eissn>1437-4315</eissn><abstract>Metastasis is the main cause of increasing cancer morbidity and mortality. However, the underlying mechanism of cancer metastasis remains largely unknown. In the present study, we identified one circular RNA (circRNA) closely related to the metastasis of colorectal cancer (CRC), namely hsa_circ_0001178. CRC patients with high hsa_circ_0001178 were more prone to have metastatic clinical features, advanced TNM stage and adverse prognosis. Stable knockdown of hsa_circ_0001178 significantly weakened CRC cell migratory and invasive capabilities
as well as lung and liver metastases
. Mechanistic study revealed that hsa_circ_0001178 acted as a competing endogenous RNA (ceRNA) for miR-382/587/616 to upregulate ZEB1 (a key trigger of epithelial-to-mesenchymal transition), thereby promoting CRC metastatic dissemination. Of note, ZEB1 could also increase hsa_circ_0001178 expression via physically binding to hsa_circ_0001178 promoter region. Collectively, our data uncover the crucial role of hsa_circ_0001178 in CRC metastasis, and targeted therapy based on this positive feedback ceRNA axis may be a promising treatment for metastatic CRC patients.</abstract><cop>Germany</cop><pub>De Gruyter</pub><pmid>31747371</pmid><doi>10.1515/hsz-2019-0350</doi><tpages>10</tpages></addata></record> |
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| subjects | Cancer Cell migration Circular RNA Colorectal cancer Colorectal carcinoma competing endogenous RNA In vivo methods and tests Invasiveness Mesenchyme Metastases Metastasis Morbidity Patients Positive feedback Ribonucleic acid RNA |
| title | Circular RNA hsa_circ_0001178 facilitates the invasion and metastasis of colorectal cancer through upregulating ZEB1 via sponging multiple miRNAs |
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