Direct capillary electrophoresis analysis of basic and acidic drugs from microliter volume of human body fluids after liquid-phase microextraction through nano-fibrous membrane
In the present work, a disposable microextraction device with a polyamide 6 nano-fibrous supported liquid membrane (SLM) is employed for the pretreatment of minute volumes of biological fluids. The device is placed in a sample vial for an at-line coupling to a commercial capillary electrophoresis in...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry 2020, Vol.412 (1), p.181-191 |
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| creator | Román-Hidalgo, Cristina Dvořák, Miloš Kubáň, Pavel Martín-Valero, María Jesús Bello-López, Miguel Ángel |
| description | In the present work, a disposable microextraction device with a polyamide 6 nano-fibrous supported liquid membrane (SLM) is employed for the pretreatment of minute volumes of biological fluids. The device is placed in a sample vial for an at-line coupling to a commercial capillary electrophoresis instrument with UV-Vis detection (CE-UV) and injections are performed fully automatically from the free acceptor solution above the SLM with no contact between the capillary and the membrane. Up to 4-fold enrichment of model basic (nortriptyline, haloperidol, loperamide, and papaverine) and acidic (ibuprofen, naproxen, ketoprofen, and diclofenac) drugs is achieved by optimizing the ratio of the donor to the acceptor solution volumes (16 to 4 μL, respectively). The actual setup enables SLM extractions from less than a drop of sample and is suitable for pretreatment of scarce human body fluids. Two unique methods are reported for efficient clean-up and enrichment of the basic and acidic drugs from capillary blood (formed as dried blood spot), serum, and urine samples, which enable their determination at therapeutic and/or toxic levels. The hyphenation of the SLM extraction with CE-UV analysis provides good repeatability (RSD, 2.4–14.9%), linearity (
r
2
, 0.988–1.000), sensitivity (LOD, 0.017–0.22 mg L
−1
), and extraction recovery (ER, 20–106%) at short extraction times (10 min) and with minimum consumption of samples and reagents.
Graphical abstract |
| doi_str_mv | 10.1007/s00216-019-02225-y |
| format | Article |
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r
2
, 0.988–1.000), sensitivity (LOD, 0.017–0.22 mg L
−1
), and extraction recovery (ER, 20–106%) at short extraction times (10 min) and with minimum consumption of samples and reagents.
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r
2
, 0.988–1.000), sensitivity (LOD, 0.017–0.22 mg L
−1
), and extraction recovery (ER, 20–106%) at short extraction times (10 min) and with minimum consumption of samples and reagents.
Graphical abstract</description><subject>Analytical Chemistry</subject><subject>Biochemistry</subject><subject>Blood</subject><subject>Body fluids</subject><subject>Body Fluids - chemistry</subject><subject>Capillary electrophoresis</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Computational fluid dynamics</subject><subject>Diclofenac</subject><subject>Drugs</subject><subject>Electrophoresis</subject><subject>Electrophoresis, Capillary - methods</subject><subject>Food Science</subject><subject>Haloperidol</subject><subject>Human body</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Ibuprofen</subject><subject>Instrument industry</subject><subject>Ketoprofen</subject><subject>Laboratory Medicine</subject><subject>Linearity</subject><subject>Liquid membranes</subject><subject>Liquid Phase Microextraction - methods</subject><subject>Liquid phases</subject><subject>Membranes, Artificial</subject><subject>Monitoring/Environmental Analysis</subject><subject>Nanofibers</subject><subject>Naproxen</subject><subject>Pharmaceutical Preparations - metabolism</subject><subject>Polyamide resins</subject><subject>Polyamides</subject><subject>Pretreatment</subject><subject>Reagents</subject><subject>Reproducibility of Results</subject><subject>Research 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capillary electrophoresis analysis of basic and acidic drugs from microliter volume of human body fluids after liquid-phase microextraction through nano-fibrous membrane</title><author>Román-Hidalgo, Cristina ; Dvořák, Miloš ; Kubáň, Pavel ; Martín-Valero, María Jesús ; Bello-López, Miguel Ángel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-8e81a77c34cd6a61b08b066e7454c733d5073a132614f73ca99a89549f3355703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Analytical Chemistry</topic><topic>Biochemistry</topic><topic>Blood</topic><topic>Body fluids</topic><topic>Body Fluids - chemistry</topic><topic>Capillary electrophoresis</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Computational fluid dynamics</topic><topic>Diclofenac</topic><topic>Drugs</topic><topic>Electrophoresis</topic><topic>Electrophoresis, Capillary - methods</topic><topic>Food Science</topic><topic>Haloperidol</topic><topic>Human body</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Ibuprofen</topic><topic>Instrument industry</topic><topic>Ketoprofen</topic><topic>Laboratory Medicine</topic><topic>Linearity</topic><topic>Liquid membranes</topic><topic>Liquid Phase Microextraction - methods</topic><topic>Liquid phases</topic><topic>Membranes, Artificial</topic><topic>Monitoring/Environmental Analysis</topic><topic>Nanofibers</topic><topic>Naproxen</topic><topic>Pharmaceutical Preparations - metabolism</topic><topic>Polyamide resins</topic><topic>Polyamides</topic><topic>Pretreatment</topic><topic>Reagents</topic><topic>Reproducibility of Results</topic><topic>Research 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Chem</addtitle><date>2020</date><risdate>2020</risdate><volume>412</volume><issue>1</issue><spage>181</spage><epage>191</epage><pages>181-191</pages><issn>1618-2642</issn><eissn>1618-2650</eissn><abstract>In the present work, a disposable microextraction device with a polyamide 6 nano-fibrous supported liquid membrane (SLM) is employed for the pretreatment of minute volumes of biological fluids. The device is placed in a sample vial for an at-line coupling to a commercial capillary electrophoresis instrument with UV-Vis detection (CE-UV) and injections are performed fully automatically from the free acceptor solution above the SLM with no contact between the capillary and the membrane. Up to 4-fold enrichment of model basic (nortriptyline, haloperidol, loperamide, and papaverine) and acidic (ibuprofen, naproxen, ketoprofen, and diclofenac) drugs is achieved by optimizing the ratio of the donor to the acceptor solution volumes (16 to 4 μL, respectively). The actual setup enables SLM extractions from less than a drop of sample and is suitable for pretreatment of scarce human body fluids. Two unique methods are reported for efficient clean-up and enrichment of the basic and acidic drugs from capillary blood (formed as dried blood spot), serum, and urine samples, which enable their determination at therapeutic and/or toxic levels. The hyphenation of the SLM extraction with CE-UV analysis provides good repeatability (RSD, 2.4–14.9%), linearity (
r
2
, 0.988–1.000), sensitivity (LOD, 0.017–0.22 mg L
−1
), and extraction recovery (ER, 20–106%) at short extraction times (10 min) and with minimum consumption of samples and reagents.
Graphical abstract</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31745611</pmid><doi>10.1007/s00216-019-02225-y</doi><tpages>11</tpages></addata></record> |
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| ispartof | Analytical and bioanalytical chemistry, 2020, Vol.412 (1), p.181-191 |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Analytical Chemistry Biochemistry Blood Body fluids Body Fluids - chemistry Capillary electrophoresis Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Computational fluid dynamics Diclofenac Drugs Electrophoresis Electrophoresis, Capillary - methods Food Science Haloperidol Human body Humans Hydrogen-Ion Concentration Ibuprofen Instrument industry Ketoprofen Laboratory Medicine Linearity Liquid membranes Liquid Phase Microextraction - methods Liquid phases Membranes, Artificial Monitoring/Environmental Analysis Nanofibers Naproxen Pharmaceutical Preparations - metabolism Polyamide resins Polyamides Pretreatment Reagents Reproducibility of Results Research Paper Urine |
| title | Direct capillary electrophoresis analysis of basic and acidic drugs from microliter volume of human body fluids after liquid-phase microextraction through nano-fibrous membrane |
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