Beneficial modulation of the tumor microenvironment and generation of anti-tumor responses by TLR9 agonist lefitolimod alone and in combination with checkpoint inhibitors

Activation of Toll-like receptor 9 (TLR9) is known to foster innate and adaptive immune responses and thus improve immune-mediated control of malignant disease. Lefitolimod is a potent TLR9 agonist without chemical modification developed for immunotherapeutic strategies. Modulation of the tumor micr...

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Veröffentlicht in:	Oncoimmunology 2019-12, Vol.8 (12), p.e1659096-e1659096
Hauptverfasser:	Kapp, Kerstin, Volz, Barbara, Oswald, Detlef, Wittig, Burghardt, Baumann, Matthias, Schmidt, Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	anti-tumor memory cancer immunotherapy immune checkpoint inhibitors MGN1703 Original Research tumor microenvironment
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