The NLRP3 Inflammasome and Its Role in Sepsis Development

The pathophysiology of sepsis is extremely complex. During this disease, the exacerbation of the inflammatory response causes oxidative stress, alterations in mitochondrial energy dynamics, and multiple organ failure. Some studies have highlighted the important role of the NLRP3 inflammasome in seps...

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Veröffentlicht in:	Inflammation 2020-02, Vol.43 (1), p.24-31
Hauptverfasser:	Danielski, Lucinéia Gainski, Giustina, Amanda Della, Bonfante, Sandra, Barichello, Tatiana, Petronilho, Fabricia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Caspase-1 Cytokines - metabolism Humans IL-1β Immunology Inflammasomes Inflammasomes - immunology Inflammasomes - metabolism Inflammation Interleukin 18 Internal Medicine Macromolecules Mitochondria NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Oxidative stress Pathology Pharmacology/Toxicology Review Rheumatology Sepsis Sepsis - immunology Sepsis - metabolism Sepsis - physiopathology Signal Transduction
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