A Reconfigurable In Vitro Model for Studying the Blood–Brain Barrier

Much of what is currently known about the role of the blood–brain barrier (BBB) in regulating the passage of chemicals from the blood stream to the central nervous system (CNS) comes from animal in vivo models (requiring extrapolation to human relevance) and 2D static in vitro systems, which fail to...

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Veröffentlicht in:	Annals of biomedical engineering 2020-02, Vol.48 (2), p.780-793
Hauptverfasser:	Moya, Monica L., Triplett, Michael, Simon, Melinda, Alvarado, Javier, Booth, Ross, Osburn, Joanne, Soscia, David, Qian, Fang, Fischer, Nicholas O., Kulp, Kristen, Wheeler, Elizabeth K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Biophysics Blood Blood-brain barrier Brain Cell culture Central nervous system Classical Mechanics Computational fluid dynamics Efflux Fluid dynamics Hydrodynamics Organic chemistry Original Article Tight junctions Two dimensional models
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