Long and short isoforms of c-FLIP act as control checkpoints of DED filament assembly

The assembly of the death-inducing signaling complex (DISC) and death effector domain (DED) filaments at CD95/Fas initiates extrinsic apoptosis. Procaspase-8 activation at the DED filaments is controlled by short and long c-FLIP isoforms. Despite apparent progress in understanding the assembly of CD...

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Veröffentlicht in:	Oncogene 2020-02, Vol.39 (8), p.1756-1772
Hauptverfasser:	Hillert, Laura K., Ivanisenko, Nikita V., Espe, Johannes, König, Corinna, Ivanisenko, Vladimir A., Kähne, Thilo, Lavrik, Inna N.
Format:	Artikel
Sprache:	eng
Schlagworte:	101/58 631/45/475 631/80/82/23 96 96/1 96/2 96/31 96/95 Amino Acid Sequence Apoptosis c-FLIP protein CASP8 and FADD-Like Apoptosis Regulating Protein - chemistry CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism CD95 antigen Cell Biology Cellular proteins Death Domain Receptor Signaling Adaptor Proteins - metabolism Death Effector Domain FADD protein fas Receptor - metabolism Filaments FLIP protein Gene expression Genetic aspects Health aspects HeLa Cells Human Genetics Humans Internal Medicine Isoforms Jurkat Cells Mass spectroscopy Medicine Medicine & Public Health Models, Molecular Oncology Protein Isoforms - metabolism Protein Transport
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