Silencing of long noncoding RNA SRRM2‐AS exerts suppressive effects on angiogenesis in nasopharyngeal carcinoma via activating MYLK‐mediated cGMP‐PKG signaling pathway

Long noncoding RNAs (lncRNAs) play a crucial role in several malignances, involving nasopharyngeal carcinoma (NPC), a heterogeneous disease. This study investigated mechanism of serine/arginine repetitive matrix protein 2‐alternative splicing (SRRM2‐AS) in NPC cell proliferation, differentiation, an...

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Veröffentlicht in:	Journal of cellular physiology 2020-11, Vol.235 (11), p.7757-7768
Hauptverfasser:	Chen, Shaoqing, Lv, Linrong, Zhan, Zhengyu, Wang, Xiaolang, You, Zhenyu, Luo, Xiao, You, Haoyuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alternative Splicing Angiogenesis Apoptosis Arginine BAX protein Bcl-x protein Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Caspase-3 Cell cycle Cell differentiation Cell growth Cell proliferation cGMP‐PKG signaling pathway Colonies Cyclic GMP Cyclic GMP-Dependent Protein Kinases - genetics Cyclic GMP-Dependent Protein Kinases - metabolism differentiation DNA microarrays Female Gene Expression Regulation, Neoplastic - physiology Growth factors Humans Kinases Lymphoma Male Matrix protein Middle Aged MYLK Myosin Myosin-light-chain kinase Myosin-Light-Chain Kinase - genetics Myosin-Light-Chain Kinase - metabolism Nasopharyngeal carcinoma Nasopharyngeal Carcinoma - genetics Nasopharyngeal Carcinoma - metabolism Nasopharyngeal Carcinoma - pathology Nasopharyngeal Neoplasms - genetics Nasopharyngeal Neoplasms - metabolism Nasopharyngeal Neoplasms - pathology Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Proliferating cell nuclear antigen proliferation Proteins Ribonucleic acid RNA RNA, Long Noncoding - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism RNA-mediated interference Serine Signal transduction Signaling siRNA Splicing SRRM2‐AS Throat cancer Transfection Vascular endothelial growth factor
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