Significance of TIM3 expression in cancer: From biology to the clinic

Targeting inhibitory immune checkpoint molecules has dramatically changed treatment paradigms in medical oncology. Understanding the best strategies to unleash a pre-existing immune response or to induce an efficient immune response against tumors has emerged as a research priority. In this work, we...

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Veröffentlicht in:	Seminars in oncology 2019-08, Vol.46 (4-5), p.372-379
Hauptverfasser:	Solinas, Cinzia, De Silva, Pushpamali, Bron, Dominique, Willard-Gallo, Karen, Sangiolo, Dario
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers, Tumor Cancer Checkpoints Clinical Trials as Topic Gene Expression Regulation, Neoplastic Hepatitis A Virus Cellular Receptor 2 - antagonists & inhibitors Hepatitis A Virus Cellular Receptor 2 - genetics Hepatitis A Virus Cellular Receptor 2 - metabolism Humans Immunomodulation - drug effects Immunomodulation - genetics Immunomodulation - immunology Immunotherapy Molecular Targeted Therapy Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology PD-1 T cell exhaustion T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism TIM3 Treatment Outcome
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