Assessment of copper, iron, zinc and manganese status and speciation in patients with Parkinson’s disease: A pilot study
•Serum, hair, and urine Fe, Cu, Mn, and Zn level were assessed with ICP-DRC-MS.•Fe, Cu, Mn, and Zn speciation was performed with HPLC-ICP-DRC-MS.•Total Fe, Cu, Mn, and Zn levels did not differ between patients and controls.•Cu/ceruloplasmin copper was significantly reduced in Parkinson’s disease.•Mn...
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| Veröffentlicht in: | Journal of trace elements in medicine and biology 2020-05, Vol.59, p.126423-126423, Article 126423 |
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| creator | Ajsuvakova, Olga P. Tinkov, Alexey A. Willkommen, Desiree Skalnaya, Anastasia A. Danilov, Alexey B. Pilipovich, Anna A. Aschner, Michael Skalny, Anatoly V. Michalke, Bernhard Skalnaya, Margarita G. |
| description | •Serum, hair, and urine Fe, Cu, Mn, and Zn level were assessed with ICP-DRC-MS.•Fe, Cu, Mn, and Zn speciation was performed with HPLC-ICP-DRC-MS.•Total Fe, Cu, Mn, and Zn levels did not differ between patients and controls.•Cu/ceruloplasmin copper was significantly reduced in Parkinson’s disease.•Mn-albumin fraction in PD patients was more than 4-fold higher.
The objective of this pilot study was to assess iron (Fe), copper (Cu), zinc (Zn), and manganese (Mn) status (hair, serum, and urine) and speciation (serum) in Parkinson’s disease (PD) patients.
A pilot study involving a total of 27 subjects (13 PD patients, 14 controls) was performed. Serum, urine, and hair metal content was assessed using ICP-MS. Speciation analysis of Cu, Zn, Fe, and Mn was performed using a hybrid HPLC-ICP-MS system.
Group comparisons did not reveal any significant group difference in serum Cu, Zn, Fe, and Mn total metal level between PD patients and controls. Speciation analysis revealed a significant decrease in Cu/ceruloplasmin copper in association with elevation of low-molecular weight species (amino acids)-bound copper. It is proposed that in PD, binding of Cu(II) ions to ceruloplasmin is reduced and free copper ions coordinate with low molecular weight ligands. The level of Mn-albumin complexes in PD patients was more than 4-fold higher as compared to the respective value in the control group. The observed difference may be considered as a marker of redistribution between high and low molecular weight ligands.
Metal speciation is significantly affected in serum of PD-patients. These findings are indicative of the potential role of metal metabolism and PD pathogenesis, although the exact mechanisms of such associations require further detailed studies. |
| doi_str_mv | 10.1016/j.jtemb.2019.126423 |
| format | Article |
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The objective of this pilot study was to assess iron (Fe), copper (Cu), zinc (Zn), and manganese (Mn) status (hair, serum, and urine) and speciation (serum) in Parkinson’s disease (PD) patients.
A pilot study involving a total of 27 subjects (13 PD patients, 14 controls) was performed. Serum, urine, and hair metal content was assessed using ICP-MS. Speciation analysis of Cu, Zn, Fe, and Mn was performed using a hybrid HPLC-ICP-MS system.
Group comparisons did not reveal any significant group difference in serum Cu, Zn, Fe, and Mn total metal level between PD patients and controls. Speciation analysis revealed a significant decrease in Cu/ceruloplasmin copper in association with elevation of low-molecular weight species (amino acids)-bound copper. It is proposed that in PD, binding of Cu(II) ions to ceruloplasmin is reduced and free copper ions coordinate with low molecular weight ligands. The level of Mn-albumin complexes in PD patients was more than 4-fold higher as compared to the respective value in the control group. The observed difference may be considered as a marker of redistribution between high and low molecular weight ligands.
Metal speciation is significantly affected in serum of PD-patients. These findings are indicative of the potential role of metal metabolism and PD pathogenesis, although the exact mechanisms of such associations require further detailed studies.</description><identifier>ISSN: 0946-672X</identifier><identifier>EISSN: 1878-3252</identifier><identifier>DOI: 10.1016/j.jtemb.2019.126423</identifier><identifier>PMID: 31733982</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Aged ; Copper ; Copper - analysis ; Copper - blood ; Copper - urine ; Female ; Hair - chemistry ; Humans ; Iron ; Iron - analysis ; Iron - blood ; Iron - urine ; Male ; Manganese ; Manganese - analysis ; Manganese - blood ; Manganese - urine ; Middle Aged ; Parkinson Disease - blood ; Parkinson Disease - diagnosis ; Parkinson Disease - urine ; Parkinson’ disease ; Pilot Projects ; Speciation analysis ; Zinc - analysis ; Zinc - blood ; Zinc - urine</subject><ispartof>Journal of trace elements in medicine and biology, 2020-05, Vol.59, p.126423-126423, Article 126423</ispartof><rights>2019</rights><rights>Copyright © 2019. Published by Elsevier GmbH.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-59a30b272480e2a383e61d831bdd6c89c98c79ee10074bbdc469b113ecd9f7a63</citedby><cites>FETCH-LOGICAL-c359t-59a30b272480e2a383e61d831bdd6c89c98c79ee10074bbdc469b113ecd9f7a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jtemb.2019.126423$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31733982$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ajsuvakova, Olga P.</creatorcontrib><creatorcontrib>Tinkov, Alexey A.</creatorcontrib><creatorcontrib>Willkommen, Desiree</creatorcontrib><creatorcontrib>Skalnaya, Anastasia A.</creatorcontrib><creatorcontrib>Danilov, Alexey B.</creatorcontrib><creatorcontrib>Pilipovich, Anna A.</creatorcontrib><creatorcontrib>Aschner, Michael</creatorcontrib><creatorcontrib>Skalny, Anatoly V.</creatorcontrib><creatorcontrib>Michalke, Bernhard</creatorcontrib><creatorcontrib>Skalnaya, Margarita G.</creatorcontrib><title>Assessment of copper, iron, zinc and manganese status and speciation in patients with Parkinson’s disease: A pilot study</title><title>Journal of trace elements in medicine and biology</title><addtitle>J Trace Elem Med Biol</addtitle><description>•Serum, hair, and urine Fe, Cu, Mn, and Zn level were assessed with ICP-DRC-MS.•Fe, Cu, Mn, and Zn speciation was performed with HPLC-ICP-DRC-MS.•Total Fe, Cu, Mn, and Zn levels did not differ between patients and controls.•Cu/ceruloplasmin copper was significantly reduced in Parkinson’s disease.•Mn-albumin fraction in PD patients was more than 4-fold higher.
The objective of this pilot study was to assess iron (Fe), copper (Cu), zinc (Zn), and manganese (Mn) status (hair, serum, and urine) and speciation (serum) in Parkinson’s disease (PD) patients.
A pilot study involving a total of 27 subjects (13 PD patients, 14 controls) was performed. Serum, urine, and hair metal content was assessed using ICP-MS. Speciation analysis of Cu, Zn, Fe, and Mn was performed using a hybrid HPLC-ICP-MS system.
Group comparisons did not reveal any significant group difference in serum Cu, Zn, Fe, and Mn total metal level between PD patients and controls. Speciation analysis revealed a significant decrease in Cu/ceruloplasmin copper in association with elevation of low-molecular weight species (amino acids)-bound copper. It is proposed that in PD, binding of Cu(II) ions to ceruloplasmin is reduced and free copper ions coordinate with low molecular weight ligands. The level of Mn-albumin complexes in PD patients was more than 4-fold higher as compared to the respective value in the control group. The observed difference may be considered as a marker of redistribution between high and low molecular weight ligands.
Metal speciation is significantly affected in serum of PD-patients. These findings are indicative of the potential role of metal metabolism and PD pathogenesis, although the exact mechanisms of such associations require further detailed studies.</description><subject>Aged</subject><subject>Copper</subject><subject>Copper - analysis</subject><subject>Copper - blood</subject><subject>Copper - urine</subject><subject>Female</subject><subject>Hair - chemistry</subject><subject>Humans</subject><subject>Iron</subject><subject>Iron - analysis</subject><subject>Iron - blood</subject><subject>Iron - urine</subject><subject>Male</subject><subject>Manganese</subject><subject>Manganese - analysis</subject><subject>Manganese - blood</subject><subject>Manganese - urine</subject><subject>Middle Aged</subject><subject>Parkinson Disease - blood</subject><subject>Parkinson Disease - diagnosis</subject><subject>Parkinson Disease - urine</subject><subject>Parkinson’ disease</subject><subject>Pilot Projects</subject><subject>Speciation analysis</subject><subject>Zinc - analysis</subject><subject>Zinc - blood</subject><subject>Zinc - urine</subject><issn>0946-672X</issn><issn>1878-3252</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1uFDEQhS0EIkPgBEjISxbpwT_9YyOxGEUEkCKFBUjsLLddAx6m7cblBiWrXIPrcRKcTGCZVZVK773S-wh5ztmaM96_2q13BaZxLRjXay76VsgHZMXVoBopOvGQrJhu-6YfxJcj8gRxxxgfOiUekyPJBym1EitytUEExAlioWlLXZpnyCc05BRP6FWIjtro6WTjVxsBgWKxZcHbI87ggi0hRRoinetWQ5D-CuUb_Wjz9xAxxT_Xv5H6gGARXtMNncM-lZqy-Mun5NHW7hGe3c1j8vns7afT9835xbsPp5vzxslOl6bTVrJRDKJVDISVSkLPvZJ89L53Sjut3KABOGNDO47etb0eOZfgvN4OtpfH5OUhd87pxwJYzBTQwX5fG6UFjZC864TmWlepPEhdTogZtmbOYbL50nBmbqCbnbmFbm6gmwP06npx92AZJ_D_Pf8oV8GbgwBqzZ8BskFXYTnwIYMrxqdw74O_gv2WSw</recordid><startdate>202005</startdate><enddate>202005</enddate><creator>Ajsuvakova, Olga P.</creator><creator>Tinkov, Alexey A.</creator><creator>Willkommen, Desiree</creator><creator>Skalnaya, Anastasia A.</creator><creator>Danilov, Alexey B.</creator><creator>Pilipovich, Anna A.</creator><creator>Aschner, Michael</creator><creator>Skalny, Anatoly V.</creator><creator>Michalke, Bernhard</creator><creator>Skalnaya, Margarita G.</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202005</creationdate><title>Assessment of copper, iron, zinc and manganese status and speciation in patients with Parkinson’s disease: A pilot study</title><author>Ajsuvakova, Olga P. ; Tinkov, Alexey A. ; Willkommen, Desiree ; Skalnaya, Anastasia A. ; Danilov, Alexey B. ; Pilipovich, Anna A. ; Aschner, Michael ; Skalny, Anatoly V. ; Michalke, Bernhard ; Skalnaya, Margarita G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-59a30b272480e2a383e61d831bdd6c89c98c79ee10074bbdc469b113ecd9f7a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Copper</topic><topic>Copper - analysis</topic><topic>Copper - blood</topic><topic>Copper - urine</topic><topic>Female</topic><topic>Hair - chemistry</topic><topic>Humans</topic><topic>Iron</topic><topic>Iron - analysis</topic><topic>Iron - blood</topic><topic>Iron - urine</topic><topic>Male</topic><topic>Manganese</topic><topic>Manganese - analysis</topic><topic>Manganese - blood</topic><topic>Manganese - urine</topic><topic>Middle Aged</topic><topic>Parkinson Disease - blood</topic><topic>Parkinson Disease - diagnosis</topic><topic>Parkinson Disease - urine</topic><topic>Parkinson’ disease</topic><topic>Pilot Projects</topic><topic>Speciation analysis</topic><topic>Zinc - analysis</topic><topic>Zinc - blood</topic><topic>Zinc - urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ajsuvakova, Olga P.</creatorcontrib><creatorcontrib>Tinkov, Alexey A.</creatorcontrib><creatorcontrib>Willkommen, Desiree</creatorcontrib><creatorcontrib>Skalnaya, Anastasia A.</creatorcontrib><creatorcontrib>Danilov, Alexey B.</creatorcontrib><creatorcontrib>Pilipovich, Anna A.</creatorcontrib><creatorcontrib>Aschner, Michael</creatorcontrib><creatorcontrib>Skalny, Anatoly V.</creatorcontrib><creatorcontrib>Michalke, Bernhard</creatorcontrib><creatorcontrib>Skalnaya, Margarita G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of trace elements in medicine and biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ajsuvakova, Olga P.</au><au>Tinkov, Alexey A.</au><au>Willkommen, Desiree</au><au>Skalnaya, Anastasia A.</au><au>Danilov, Alexey B.</au><au>Pilipovich, Anna A.</au><au>Aschner, Michael</au><au>Skalny, Anatoly V.</au><au>Michalke, Bernhard</au><au>Skalnaya, Margarita G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of copper, iron, zinc and manganese status and speciation in patients with Parkinson’s disease: A pilot study</atitle><jtitle>Journal of trace elements in medicine and biology</jtitle><addtitle>J Trace Elem Med Biol</addtitle><date>2020-05</date><risdate>2020</risdate><volume>59</volume><spage>126423</spage><epage>126423</epage><pages>126423-126423</pages><artnum>126423</artnum><issn>0946-672X</issn><eissn>1878-3252</eissn><abstract>•Serum, hair, and urine Fe, Cu, Mn, and Zn level were assessed with ICP-DRC-MS.•Fe, Cu, Mn, and Zn speciation was performed with HPLC-ICP-DRC-MS.•Total Fe, Cu, Mn, and Zn levels did not differ between patients and controls.•Cu/ceruloplasmin copper was significantly reduced in Parkinson’s disease.•Mn-albumin fraction in PD patients was more than 4-fold higher.
The objective of this pilot study was to assess iron (Fe), copper (Cu), zinc (Zn), and manganese (Mn) status (hair, serum, and urine) and speciation (serum) in Parkinson’s disease (PD) patients.
A pilot study involving a total of 27 subjects (13 PD patients, 14 controls) was performed. Serum, urine, and hair metal content was assessed using ICP-MS. Speciation analysis of Cu, Zn, Fe, and Mn was performed using a hybrid HPLC-ICP-MS system.
Group comparisons did not reveal any significant group difference in serum Cu, Zn, Fe, and Mn total metal level between PD patients and controls. Speciation analysis revealed a significant decrease in Cu/ceruloplasmin copper in association with elevation of low-molecular weight species (amino acids)-bound copper. It is proposed that in PD, binding of Cu(II) ions to ceruloplasmin is reduced and free copper ions coordinate with low molecular weight ligands. The level of Mn-albumin complexes in PD patients was more than 4-fold higher as compared to the respective value in the control group. The observed difference may be considered as a marker of redistribution between high and low molecular weight ligands.
Metal speciation is significantly affected in serum of PD-patients. These findings are indicative of the potential role of metal metabolism and PD pathogenesis, although the exact mechanisms of such associations require further detailed studies.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>31733982</pmid><doi>10.1016/j.jtemb.2019.126423</doi><tpages>1</tpages></addata></record> |
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| subjects | Aged Copper Copper - analysis Copper - blood Copper - urine Female Hair - chemistry Humans Iron Iron - analysis Iron - blood Iron - urine Male Manganese Manganese - analysis Manganese - blood Manganese - urine Middle Aged Parkinson Disease - blood Parkinson Disease - diagnosis Parkinson Disease - urine Parkinson’ disease Pilot Projects Speciation analysis Zinc - analysis Zinc - blood Zinc - urine |
| title | Assessment of copper, iron, zinc and manganese status and speciation in patients with Parkinson’s disease: A pilot study |
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