Cecal Tumorigenesis in Aryl Hydrocarbon Receptor–Deficient Mice Depends on Cecum-Specific Mitogen-Activated Protein Kinase Pathway Activation and Inflammation

The aryl hydrocarbon receptor (AhR) is a transcription factor known as a dioxin receptor. Recently, Ahr−/− mice were revealed to develop cecal tumors with inflammation and Wnt/β-catenin pathway activation. However, whether β-catenin degradation is AhR dependent remains unclear. To determine whether...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The American journal of pathology 2020-02, Vol.190 (2), p.453-468
Hauptverfasser:	Matoba, Hisanori, Takamoto, Masaya, Fujii, Chifumi, Kawakubo, Masatomo, Kasuga, Eriko, Matsumura, Tomio, Natori, Tatsuya, Misawa, Ken, Taniguchi, Shun'ichiro, Nakayama, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - immunology Adenocarcinoma - metabolism Adenocarcinoma - pathology Animals Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Basic Helix-Loop-Helix Transcription Factors - physiology Carcinogenesis - immunology Carcinogenesis - metabolism Carcinogenesis - pathology Cecal Neoplasms - immunology Cecal Neoplasms - metabolism Cecal Neoplasms - pathology Colorectal Neoplasms - immunology Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Female Hyperplasia - immunology Hyperplasia - metabolism Hyperplasia - pathology Inflammation - immunology Inflammation - metabolism Inflammation - pathology Inflammation Mediators - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinases - metabolism Phosphorylation Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - metabolism Receptors, Aryl Hydrocarbon - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!