Benzoylaconitine Inhibits Production of IL-6 and IL-8 via MAPK, Akt, NF-κB Signaling in IL-1β-Induced Human Synovial Cells

Benzoylaconitine (BAC), the main hydrolysate of aconitine, is a lower toxic monoester type alkaloid considered as the pharmacodynamic constituent in Aconitum species. In this study, the effects and mechanisms of BAC on production of inflammatory cytokines interleukin (IL)-6 and IL-8 were investigate...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2020/02/01, Vol.43(2), pp.334-339
Hauptverfasser:	Yu, Hao-Heng, Li, Ming, Li, Yuan-Bo, Lei, Bing-Bing, Yuan, Xin, Xing, Xue-Kun, Xie, Yun-Fei, Wang, Mian, Wang, Lei, Yang, Hai-Jie, Feng, Zhi-Wei, Cheng, Bin-Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Aconitum AKT protein benzoylaconitine cytokine IL-1β Inflammation Interleukin 6 Interleukin 8 Kinases MAP kinase NF-κB protein Pharmacodynamics Phosphorylation Protein kinase Proteins Rheumatoid arthritis signaling pathway Synaptotagmin synovial cell Transposition
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