Protective effect of amygdalin on epithelial–mesenchymal transformation in experimental chronic obstructive pulmonary disease mice

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory pulmonary disease characterized by continuous, progressive limitation of airflow. Airway remodelling, which is correlated with epithelial–mesenchymal transitions (EMTs), is a typical pathophysiological change of COPD. Amygdalin,...

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Veröffentlicht in:	Phytotherapy research 2019-03, Vol.33 (3), p.808-817
Hauptverfasser:	Wang, Ziyan, Fang, Keyong, Wang, Guoqiang, Guan, Xuewa, Pang, Zhiqiang, Guo, Yingqiao, Yuan, Yuze, Ran, Nan, Liu, Yue, Wang, Fang
Format:	Artikel
Sprache:	eng
Schlagworte:	active ingredients Air flow almonds amygdalin cadherins Chronic obstructive pulmonary disease Cigarette smoke Disease control E-cadherin Enzyme-linked immunosorbent assay Epithelial cells epithelial–mesenchymal transition Fibrosis Genetic transformation Herbal medicine human cell lines humans immunohistochemistry Lung diseases lungs Mesenchyme Mice Morphology Obstructive lung disease Oriental traditional medicine Pharmacology protective effect quantitative polymerase chain reaction Respiratory tract respiratory tract diseases Smad2 protein Smoke staining TGF‐β1 Tissues Traditional Chinese medicine transforming growth factor beta 1 Transforming growth factor-b1 Vimentin Western blotting
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