Renoprotective effect of calycosin in high fat diet-fed/STZ injected rats: Effect on IL-33/ST2 signaling, oxidative stress and fibrosis suppression

Type 2 diabetes mellitus (T2DM) is a disease with a drastically growing worldwide prevalence. It is usually associated with numerous complications of which; diabetic nephropathy (DN); is a main complication of microvasculature and more seriously, a common cause of end-stage renal disease (ESRD). Unf...

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Veröffentlicht in:	Chemico-biological interactions 2020-01, Vol.315, p.108897-108897, Article 108897
Hauptverfasser:	Elsherbiny, Nehal M., Said, Eman, Atef, Hoda, Zaitone, Sawsan A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calycosin Cytokines - metabolism Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Type 2 - chemically induced Diabetes Mellitus, Type 2 - metabolism Diabetic Nephropathies - drug therapy Diabetic Nephropathies - metabolism Diet, High-Fat - adverse effects Fibrosis Fibrosis - drug therapy Fibrosis - metabolism HFD/STZ IL33 Inflammation - drug therapy Inflammation - metabolism Interleukin-33 - metabolism Isoflavones - pharmacology Kidney - drug effects Kidney - metabolism Male Nrf2 Oxidative Stress - drug effects Protective Agents - pharmacology Rats Rats, Sprague-Dawley Receptors, Interleukin-1 - metabolism Signal Transduction - drug effects ST2 Streptozocin - pharmacology
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