Early Intrathecal T Helper 17.1 Cell Activity in Huntington Disease

Objective Huntington disease (HD) is an autosomal dominantly inherited neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin (HTT) gene. No disease‐modifying therapy exists for the treatment of patients with HD. The purpose of this study was therefore to investigate early dis...

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Veröffentlicht in:	Annals of neurology 2020-02, Vol.87 (2), p.246-255
Hauptverfasser:	Essen, Marina R., Hellem, Marie N. N., Vinther‐Jensen, Tua, Ammitzbøll, Cecilie, Hansen, Rikke H., Hjermind, Lena E., Nielsen, Troels T., Nielsen, Jørgen E., Sellebjerg, Finn
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Adult Aged Cell Proliferation Cerebrospinal fluid Cytokines Cytokines - cerebrospinal fluid Cytokines - metabolism Expansion Female Flow cytometry Growth factors Helper cells Heterozygote Humans Huntingtin Huntingtin Protein - genetics Huntington Disease - cerebrospinal fluid Huntington Disease - genetics Huntington Disease - immunology Huntington Disease - physiopathology Huntington's disease Huntingtons disease Immunoassays Immunoregulation Inflammation Lymphocyte Activation - immunology Lymphocytes Lymphocytes T Male Medical treatment Middle Aged Neurodegeneration Neurodegenerative diseases Polyglutamine T-Lymphocyte Subsets - immunology Th17 Cells - immunology Th17 Cells - metabolism Trinucleotide repeat diseases Trinucleotide Repeat Expansion - genetics Trinucleotide repeats
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