Diagnostic values of thyroglobulin in lymph node fine-needle aspiration washout: a systematic review and meta-analysis diagnostic values of FNA-Tg

Thyroglobulin measurement in the needle washout after fine-needle aspiration (FNA-Tg) served as an important measurement for suspicious recurrent or metastatic lesions. We conducted a pooled analysis to evaluate the diagnostic accuracy of FNA-Tg and searched electronic databases for original article...

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Veröffentlicht in:ENDOCRINE JOURNAL 2020, Vol.67(2), pp.113-123
Hauptverfasser: Zhu, Xu-hang, Zhou, Jing-nan, Qian, Yang-yang, Yang, Ke, Wen, Qing-liang, Zhang, Qi-hong, Xia, Liang, Ge, Ming-hua, Sun, Cai-xing
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container_title ENDOCRINE JOURNAL
container_volume 67
creator Zhu, Xu-hang
Zhou, Jing-nan
Qian, Yang-yang
Yang, Ke
Wen, Qing-liang
Zhang, Qi-hong
Xia, Liang
Ge, Ming-hua
Sun, Cai-xing
description Thyroglobulin measurement in the needle washout after fine-needle aspiration (FNA-Tg) served as an important measurement for suspicious recurrent or metastatic lesions. We conducted a pooled analysis to evaluate the diagnostic accuracy of FNA-Tg and searched electronic databases for original articles in English from 1993 through 2017. Finally, a total of 22 studies containing 2,670 lymph nodes (LNs) that enrolled participants with suspicious neck LNs during thyroid nodule workup or papillary thyroid cancer (PTC) follow-up were included. In our analysis, the overall pooled sensitivity for FNA-Tg was 0.91 (95%CI: 0.87–0.93), specificity was 0.94 (95% CI: 0.91–0.96). Meta regression revealed that the cutoff value and status of serum Tg were sources of heterogeneity for sensitivity, and the cutoff value was source of heterogeneity for specificity. Additionally, the cutoff value and status of serum Tg were sources of heterogeneity in the joint model. Subgroup analysis about cut-off value showed that the choice of 1 ng/mL had highest sensitivity, 40 ng/mL had highest specificity. At last, we arrived at the conclusion that FNA-Tg measurement had high specificity and sensitivity in the early detection of LNs metastases from PTC by our meta-analysis. The technique was simple and could be recommended to apply in any FNA facility, especially when LN were small-sized. Significantly, a better standardization of criteria for FNA-Tg detection and cutoff value was required to provide useful data and to improve management of PTC patients in the future.
doi_str_mv 10.1507/endocrj.EJ18-0558
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At last, we arrived at the conclusion that FNA-Tg measurement had high specificity and sensitivity in the early detection of LNs metastases from PTC by our meta-analysis. The technique was simple and could be recommended to apply in any FNA facility, especially when LN were small-sized. 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source Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese
subjects Biopsy
Fine-needle aspirate
Lymph node
Lymph nodes
Meta-analysis
Metastases
Papillary thyroid cancer
Papillary thyroid carcinoma
Standardization
Thyroglobulin
Thyroid gland
title Diagnostic values of thyroglobulin in lymph node fine-needle aspiration washout: a systematic review and meta-analysis diagnostic values of FNA-Tg
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