Persistence of Inflammatory Phenotype in Residual Psoriatic Plaques in Patients on Effective Biologic Therapy

Many psoriasis patients treated with biologics do not achieve total skin clearance. These patients possess residual plaques despite ongoing biologic treatment. To elucidate mechanisms of plaque persistence despite overall good drug response, we studied 50 subjects: psoriasis patients with residual p...

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Veröffentlicht in:	Journal of investigative dermatology 2020-05, Vol.140 (5), p.1015-1025.e4
Hauptverfasser:	Mashiko, Shunya, Edelmayer, Rebecca M., Bi, Yingtao, Olson, Lauren M., Wetter, Joseph B., Wang, Jing, Maari, Catherine, Saint-Cyr Proulx, Etienne, Kaimal, Vivek, Li, Xuan, Salte, Katherine, Garcet, Sandra, Kannan, Arun K., Huang, Susan M., Cao, Xiaohong, Liu, Zheng, Krueger, James G., Sarfati, Marika, Bissonnette, Robert, Smith, Kathleen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological Products - therapeutic use Cells, Cultured Chronic Disease Disease Progression Female Humans Immunologic Memory Inflammation - drug therapy Inflammation - immunology Interleukin-22 Interleukins - metabolism Male Mast Cells - immunology Middle Aged Parakeratosis Phenotype Psoriasis - immunology Psoriasis - therapy Th17 Cells - immunology Young Adult
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